Suppression of polyploidy by the BRCA2 protein

Autor: W. Hofmann, Siegfried Scherneck, Manfred Schwab, Katrin Arnold, Volker Ehemann, Andreas Claas, Evgeny Sagulenko, Vitaliya Sagulenko, Larissa Savelyeva

Publikováno v: Cancer Letters. 257:65-72

Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e353f73fa436efabfd1e8ea915d08
https://doi.org/10.1016/j.canlet.2007.07.003

BRCA2: a genetic risk factor for breast cancer

Autor: Larissa Savelyeva, Andreas Claas, Manfred Schwab

Publikováno v: Cancer Letters. 175:1-8

The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4e4eb4bf7d7c4457528f1ebbef9db1
https://doi.org/10.1016/s0304-3835(01)00752-2

Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma

Autor: Lucy, Gossage, Muhammed, Murtaza, Andrew F, Slatter, Conrad P, Lichtenstein, Anne, Warren, Beverley, Haynes, Francesco, Marass, Ian, Roberts, Susan J, Shanahan, Andreas, Claas, Andrew, Dunham, Andrew P, May, Nitzan, Rosenfeld, Tim, Forshew, Tim, Eisen

Publikováno v: Genes, chromosomescancer. 53(1)

VHL is mutated in the majority of patients with clear cell renal cell carcinoma (ccRCC), with conflicting clinical relevance. Recent studies have identified recurrent mutations in histone modifying and chromatin remodeling genes, including BAP1, PBRM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c267058e7bc209f21d1420ce2e41dae1
https://pubmed.ncbi.nlm.nih.gov/24166983

Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells

Autor: Kai Oliver Henrich, Jan Mollenhauer, Annemarie Poustka, Christian Praml, Manfred Schwab, Andreas Claas, Rolf Ackermann, Wolfgang A. Schulz

Publikováno v: Praml, C, Schulz, W, Claas, A, Mollenhauer, J, Poustka, A, Ackermann, R, Schwab, M & Henrich, K-O 2008, ' Genetic variation of Aflatoxin B(1) aldehyde reductase genes (AFAR) in human tumour cells ', Cancer Letters, pp. 160-6 . https://doi.org/10.1016/j.canlet.2008.07.013

AFAR genes play a key role in the detoxification of the carcinogen Aflatoxin B(1) (AFB(1)). In the rat, Afar1 induction can prevent AFB(1)-induced liver cancer. It has been proposed that AFAR enzymes can metabolise endogenous diketones and dialdehyde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aef3ed73fa1036394428480c99b6e3e
https://pubmed.ncbi.nlm.nih.gov/18752886

Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma

Autor: Annemarie Poustka, Axel Benner, Manfred Schwab, Jan Mollenhauer, Frank Westermann, Andreas Claas, Kai Oliver Henrich, Christian Praml

Publikováno v: Henrich, K-O, Claas, A, Praml, C, Benner, A, Mollenhauer, J, Poustka, A, Schwab, M & Westermann, F 2007, ' Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. ', European Journal of Cancer, vol. 43, no. 3, pp. 607-16 . https://doi.org/10.1016/j.ejca.2006.09.023

Udgivelsesdato: 2007-Feb Deletion of a distal portion of 1p is seen in a wide range of human malignancies, including neuroblastoma. Here, a 1p36.3 commonly deleted region of 216 kb has been defined encompassing two genes, CAMTA1 and FLJ10737. Low exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468cf056afd524d77118c11b759c0b53
https://portal.findresearcher.sdu.dk/da/publications/14ceeb30-57f2-11dd-b1a1-000ea68e967b