Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrea Y. Thompson"'
Autor:
Qingyun Liu, Sabrina Jeter-Jones, Dawn Bright, Sofia Movérare-Skrtic, Peter Vogel, Jeff Liu, David Potter, Arthur T. Sands, Faika Mseeh, Petra Henning, Ulf H. Lerner, Robert Brommage, David R. Powell, Karin H Nilsson, James E. Tarver, Claes Ohlsson, Andrea Y. Thompson, Gwenn M. Hansen, Jennifer Bardenhagen, Brian Zambrowicz, Melanie K. Shadoan, Jie Cui, Deon Doree
Publikováno v:
Bone Research, Vol 7, Iss 1, Pp 1-12 (2019)
Bone Research
Bone Research
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-v
Autor:
Suma Gopinathan, Kenneth G. Carson, Alan G. E. Wilson, Zhi-Ming Ding, Bryce Alden Harrison, Damaris S. Diaz, Angela L. Harris, Debra Bruce, Nicole Cathleen Goodwin, Emily O’Neill, David R. Powell, Melinda Smith, Eric Strobel, David B. Rawlins, Wendy Xiong, Ling Li, Andrea Y. Thompson, Mary Thiel, Faika Mseeh
Publikováno v:
Journal of Medicinal Chemistry. 60:710-721
The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic pa
Autor:
Alan Wilson, Jason P. Healy, Robert Brommage, Xiaolian Xu, Qiang Han, Praveen K. Pabba, Kenneth G. Carson, Gardyan Michael Walter, James M. Schmidt, Andrea Y. Thompson, Ross Mabon, Kristen M. Terranova, Joseph Barbosa, James E. Tarver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1184-1187
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylester
Autor:
Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the effect of orally administered LX2761 on glycemic control in preclinical models. In healthy
Autor:
Wei He, Kenneth G. Carson, Victoria K. Lombardo, Praveen K. Pabba, James E. Tarver, Qiang Han, Alan Wilson, James M. Schmidt, Robert Brommage, Gardyan Michael Walter, Andrea Y. Thompson, Joseph Barbosa
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highl
Autor:
James W. Poser, Jens Pohl, Andrea Y. Thompson, Robert C. Spiro, Robin Daverman, Mohammad A. Heidaran, Chee Keng Ng
Publikováno v:
e-biomed: The Journal of Regenerative Medicine. 1:121-135
Growth and differentiation factor-5 (GDF-5) is a divergent member of the TGF-β/bone morphogenetic protein (BMP) superfamily that is required for proper skeletal patterning and joint development in ...
Autor:
Greg Plowman, James R. Dasch, J. M. Ziman, Andrea Y. Thompson, Michael G. Neubauer, A. F. Purchio, David M. Rosen, Linda Madisen, Hanne Bentz, Patricia R. Segarini
Publikováno v:
DNA and Cell Biology. 9:303-309
cDNA clones encoding osteoinductive factor (OIF) have been isolated from a bovine osteoblast library. Sequence analysis of these clones indicated that the 105-amino-acid OIF is synthesized as a larger 299-amino-acid precursor, the carboxyl terminus o
Publikováno v:
Journal of Biological Chemistry. 265:5024-5029
The complete amino acid sequence of bovine osteoinductive factor (OIF) was determined by automated Edman degradation of S-pyridylethylated bovine OIF and selected fragments. Cleavage with endoproteinase Lys-C, endoproteinase Glu-C, or endoproteinase
Publikováno v:
Journal of biomedical materials research. 62(1)
The stability and activity of recombinant growth factors administered locally for the repair of damaged tissue can be directly influenced by the physical structure and chemical composition of the delivery matrix. This study describes a novel basic fi