Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrea Y, Chan"'
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Autor:
Tahlia L. Fulton, Joshua N. Johnstone, Jing J. Tan, Krithika Balagopal, Amy Dedman, Andrea Y. Chan, Travis K. Johnson, Christen K. Mirth, Matthew D. W. Piper
Publikováno v:
Open Biology, Vol 14, Iss 8 (2024)
Nutrition and resilience are linked, though it is not yet clear how diet confers stress resistance or the breadth of stressors that it can protect against. We have previously shown that transiently restricting an essential amino acid can protect Dros
Externí odkaz:
https://doaj.org/article/689d12d7c11448ec965f1ea5f2fa152b
Autor:
Yann W. Yap, Patricia M. Rusu, Andrea Y. Chan, Barbara C. Fam, Andreas Jungmann, Samantha M. Solon-Biet, Christopher K. Barlow, Darren J. Creek, Cheng Huang, Ralf B. Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew D. W. Piper, Mathias Heikenwälder, Stephen J. Simpson, Stefan Bröer, Sofianos Andrikopoulos, Oliver J. Müller, Adam J. Rose
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are
Externí odkaz:
https://doaj.org/article/36856bb21e41464a998b62244a235694
Autor:
Yang Guo, Ze-Yan Yu, Jianxin Wu, Hutao Gong, Scott Kesteven, Siiri E Iismaa, Andrea Y Chan, Sara Holman, Silvia Pinto, Andy Pironet, Charles D Cox, Robert M Graham, Rudi Vennekens, Michael P Feneley, Boris Martinac
Publikováno v:
eLife, Vol 10 (2021)
Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac mortality. The molecular pathways in the induction of pressure overload LVH are potential targ
Externí odkaz:
https://doaj.org/article/e5eac8e184ce43e695d6df669f74745c
Autor:
Ketan Mishra, Keerat Junday, Claire M.Y. Wong, Andrea Y. Chan, Stephanie Hesselson, David W. Muller, Siiri E. Iismaa, Ashish Mehta, Robert M. Graham
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44–55 years) and can be fatal. The finding of familial clustering, including th
Externí odkaz:
https://doaj.org/article/71c421910d1e43aeae3cc17ebca17649
Autor:
James L. J. Coleman, Margaret A. Mouat, Jianxin Wu, Nikola Jancovski, Jaspreet K. Bassi, Andrea Y. Chan, David T. Humphreys, Nadine Mrad, Ze-Yan Yu, Tony Ngo, Siiri Iismaa, Cristobal G. dos Remedios, Michael P. Feneley, Andrew M. Allen, Robert M. Graham, Nicola J. Smith
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and
Externí odkaz:
https://doaj.org/article/2b7afb49aad2427da3297516bb182039
Publikováno v:
Nutrients, Vol 13, Iss 5, p 1469 (2021)
Prior studies have reported that dietary protein dilution (DPD) or amino acid dilution promotes heightened water intake (i.e., hyperdipsia) however, the exact dietary requirements and the mechanism responsible for this effect are still unknown. Here,
Externí odkaz:
https://doaj.org/article/2a21a0784891460e893398a015e43350
Autor:
Robert M. Graham, Andrea Y. Chan, Jianxin Wu, Xenia Kaidonis, Siiri E. Iismaa, Scott H. Kesteven, Michael P. Feneley, Stephen F. Vatner, Wenxing Niu
Publikováno v:
Journal of Molecular and Cellular Cardiology. 155:78-87
The 'fight or flight' response to physiological stress involves sympathetic nervous system activation, catecholamine release and adrenergic receptor stimulation. In the heart, this induces positive inotropy, previously attributed to the β1-adrenergi
Autor:
Amy M. Nicks, Sara R. Holman, Andrea Y. Chan, Michael Tsang, Paul E. Young, David T. Humphreys, Nawazish Naqvi, Ahsan Husain, Ming Li, Nicola J. Smith, Siiri E. Iismaa, Robert M. Graham
Publikováno v:
Journal of molecular and cellular cardiology. 170
Primary cardiomyocytes are invaluable for understanding postnatal heart development. However, a universal method to obtain freshly purified cardiomyocytes without using different age-dependent isolation procedures and cell culture, is lacking. Here,
Autor:
Andrea Y. Chan, Sara R. Holman, Ahsan Husain, Paul E. Young, Nicola J. Smith, Siiri E. Iismaa, Ming Li, Robert M. Graham, Nawazish Naqvi, Michael Tsang, David T. Humphreys, Amy M Nicks
Rationale: Primary cardiomyocytes are invaluable for understanding postnatal heart development and elucidating disease mechanisms in genetic and pharmacological models, however, a method to obtain freshly purified cardiomyocytes at any postnatal age,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f7c595c5885a7569c9a86ca9c41151
https://doi.org/10.1101/2021.09.30.462562
https://doi.org/10.1101/2021.09.30.462562