Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andrea Wolkerstorfer"'
Publikováno v:
Microbiology Independent Research Journal, Vol 3, Iss 1, Pp 13-24 (2016)
The biological basis for the restricted immunogenicity of some live attenuated influenza vaccine strains generated on the backbone of the cold adapted (ca) A/Singapore/1/1957/ca (H2N2) influenza A virus master strain and produced in the Vero cells wa
Externí odkaz:
https://doaj.org/article/23d9fcbff170421bb642ef86049fb758
Autor:
Christian Stanetty, Andrea Wolkerstorfer, Hassan Amer, Andreas Hofinger, Ulrich Jordis, Dirk Claßen-Houben, Paul Kosma
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 705-711 (2012)
The influenza virus infection remains a significant threat to public health and the increase of antiviral resistance to available drugs generates an urgent need for new antiviral compounds. Starting from the natural, antivirally active compound glycy
Externí odkaz:
https://doaj.org/article/d4ce2a95c3234044b36db38f74e5c191
Autor:
Eva Kowalinski, Chloe Zubieta, Andrea Wolkerstorfer, Oliver H J Szolar, Rob W H Ruigrok, Stephen Cusack
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002831 (2012)
It is generally recognised that novel antiviral drugs, less prone to resistance, would be a desirable alternative to current drug options in order to be able to treat potentially serious influenza infections. The viral polymerase, which performs tran
Externí odkaz:
https://doaj.org/article/93671a19f1824054b4976f7f33dcdd4c
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1103-1119
Pain is the most common reason for patients seeking medical care resulting in an estimated world market for analgesics of more than USD 50 billion. Pain is a highly complex, heterogeneous and dynamic process characterized by specific patterns of phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca70a58d53c705f7049833bfaf829ea
https://doi.org/10.1016/j.bmcl.2015.12.103
https://doi.org/10.1016/j.bmcl.2015.12.103
Publikováno v:
Nucleic Acids Research; Vol 41
Nucleic Acids Research
Nucleic Acids Research
Influenza virus uses a unique cap-snatching mechanism characterized by hijacking and cleavage of host capped pre-mRNAs, resulting in short capped RNAs, which are used as primers for viral mRNA synthesis. The PA subunit of influenza polymerase carries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7575ddbc5bb9c6aca6f65f59944df9c4
https://doi.org/10.1093/nar/gkt603
https://doi.org/10.1093/nar/gkt603
Publikováno v:
Microbiology Independent Research Journal, Vol 3, Iss 1, Pp 13-24 (2016)
The biological basis for the restricted immunogenicity of some live attenuated influenza vaccine strains generated on the backbone of the cold adapted (ca) A/Singapore/1/1957/ca (H2N2) influenza A virus master strain and produced in the Vero cells wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e560e9cce0430d404f80470bad7eb26
https://zenodo.org/record/3858043
https://zenodo.org/record/3858043
Publikováno v:
ChemInform. 47
Pain is the most common reason for patients seeking medical care resulting in an estimated world market for analgesics of more than USD 50 billion. Pain is a highly complex, heterogeneous and dynamic process characterized by specific patterns of phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662b2f851cd1fa96a2f499298c7d3cfd
https://doi.org/10.1002/chin.201614263
https://doi.org/10.1002/chin.201614263
Autor:
Oliver Szolar, Maria Hauner, Bärbel Schröfelbauer, Andrea Wolkerstorfer, Wolfgang Ernst, Johanna Raffetseder
Publikováno v:
Biochemical Journal. 421:473-482
The triterpene glycoside glycyrrhizin is the main active compound in liquorice. It is used as a herbal medicine owing to its anticancer, antiviral and anti-inflammatory properties. Its mode of action, however, remains widely unknown. In the present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9889a9dc8195b26f6c8f0badfdde5d
https://doi.org/10.1042/bj20082416
https://doi.org/10.1042/bj20082416
Autor:
Guo-Qing Tang, Stephen Cusack, Helmut Buschmann, Georg Hinterkörner, Franz-Ferdinand Roch, Andrea Wolkerstorfer, John Menke, Barbara Butzendobler, Kausiki Datta
Publikováno v:
Assay and drug development technologies. 13(8)
Novel antiviral drugs, which are less prone to resistance development, are desirable alternatives to the currently approved drugs for the treatment of potentially serious influenza virus infections. The viral polymerase is highly conserved and serves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ab46fafff4574569c7301de3482370
https://pubmed.ncbi.nlm.nih.gov/26461433
https://pubmed.ncbi.nlm.nih.gov/26461433
Autor:
Oliver Szolar, Antoine Fortuné, Jean-Luc Décout, Andrea Wolkerstorfer, Delphine Guilligay, Thomas Lunardi, Stephen Cusack, Stéphane Pautus, Joe Lewis, Peter Sehr
Publikováno v:
Journal of medicinal chemistry. 56(21)
The heterotrimeric influenza virus polymerase performs replication and transcription of viral RNA in the nucleus of infected cells. Transcription by "cap-snatching" requires that host-cell pre-mRNAs are bound via their 5' cap to the PB2 subunit. Thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9cef0fe21bfb410e36bb46e37eb266
https://pubmed.ncbi.nlm.nih.gov/24134208
https://pubmed.ncbi.nlm.nih.gov/24134208