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of 3
pro vyhledávání: '"Andrea Wiget"'
Autor:
Wolfgang Jahnke, Johannes Paladini, Judith M. Habazettl, Andrea Wiget, Alice Loo, Sandra W. Cowan Jacob, Stephan Grzesiek, Paul W. Manley
Publikováno v:
Angewandte Chemie. 134
Soellner published on the interplay between allosteric and adenosine triphosphate (ATP)-competitive inhibitors of ABL kinase, showing that the latter preferably binds to different conformational states of ABL compared to allosteric agents that specif
Autor:
Wolfgang Jahnke, Sandra W. Cowan-Jacob, Paul W. Manley, Andrea Wiget, Alice Loo, Johannes Schlotte, Louise Barys, Peter Schuld, Judith Habazettl, Stephan Grzesiek
Publikováno v:
Blood. 136:34-35
Tyrosine kinase inhibitors (TKIs) that inhibit the transphosphorylation activity of the BCR-ABL1 oncoprotein by binding the ATP-binding site of the catalytic domain of protein kinases are well established as being effective drugs for the treatments o
Autor:
Brigitte D'Arcy, Martine Stihle, Reinhard Sterner, Ralf Thoma, Tobias Seitz, Jörg Benz, Andrea Wiget, Michael Hennig, Armin Ruf, Guillaume A. Schoch
Publikováno v:
Journal of molecular biology. 403(4)
The human glucocorticoid receptor ligand-binding domain (hGR-LBD) is an important drug target for the treatment of various diseases. However, the low intrinsic stability and solubility of hGR-LBD have rendered its purification and biophysical charact