Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Andrea Viale"'
Autor:
Natthakan Thongon, Feiyang Ma, Natalia Baran, Pamela Lockyer, Jintan Liu, Christopher Jackson, Ashley Rose, Ken Furudate, Bethany Wildeman, Matteo Marchesini, Valentina Marchica, Paola Storti, Giannalisa Todaro, Irene Ganan-Gomez, Vera Adema, Juan Jose Rodriguez-Sevilla, Yun Qing, Min Jin Ha, Rodrigo Fonseca, Caleb Stein, Caleb Class, Lin Tan, Sergio Attanasio, Guillermo Garcia-Manero, Nicola Giuliani, David Berrios Nolasco, Andrea Santoni, Claudio Cerchione, Carlos Bueso-Ramos, Marina Konopleva, Philip Lorenzi, Koichi Takahashi, Elisabet Manasanch, Gabriella Sammarelli, Rashmi Kanagal-Shamanna, Andrea Viale, Marta Chesi, Simona Colla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA damage, we investigate how MM cells become resistant to antisense oligonucleotide
Externí odkaz:
https://doaj.org/article/0ff32e3e332a47feb2ca0404a6595cec
Autor:
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L. Rose, Sanjana Srinivasan, Shan Jiang, Q. Edward Chang, Ningping Feng, Jason P. Gay, Qi Wang, Jing Wang, Philip L. Lorenzi, Lucas J. Veillon, Bo Wei, John N. Weinstein, Angela K. Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A. Lyssiotis, Joseph R. Marszalek, Giulio F. Draetta, Haoqiang Ying
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumor growth and therapy resistance
Externí odkaz:
https://doaj.org/article/ef0f3fa470bc4ac8bab02e6b16959230
Autor:
Natthakan Thongon, Feiyang MA, Pamela Lockyer, Natalia Baran, Jintan Liu, Caleb Class, Lin Tan, Paola Storti, Valentina Marchica, Irene Ganan-Gomez, Bethany Wildeman, Vera Adema, Philip Lorenzi, Rodrigo Fonseca, Marta Chesi, Elisabeth Manasanch, Andrea Viale, Simona Colla
Publikováno v:
HemaSphere, Vol 7, p e91269c8 (2023)
Externí odkaz:
https://doaj.org/article/8fa9d000b6b94fada3a3a87be89c2365
Autor:
Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb A. Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Joseph R. Marszalek, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates
Externí odkaz:
https://doaj.org/article/a1a1a41f3dcc4a47a61b299fda338c49
Autor:
Francesca Citron, Ilenia Segatto, Lorena Musco, Ilenia Pellarin, Gian Luca Rampioni Vinciguerra, Giovanni Franchin, Giuseppe Fanetti, Francesco Miccichè, Vittorio Giacomarra, Valentina Lupato, Andrea Favero, Isabella Concina, Sanjana Srinivasan, Michele Avanzo, Isabella Castiglioni, Luigi Barzan, Sandro Sulfaro, Gianluigi Petrone, Andrea Viale, Giulio F Draetta, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-20 (2021)
Abstract Radiotherapy (RT) plus the anti‐EGFR monoclonal antibody Cetuximab (CTX) is an effective combination therapy for a subset of head and neck squamous cell carcinoma (HNSCC) patients. However, predictive markers of efficacy are missing, resul
Externí odkaz:
https://doaj.org/article/4189e7579da4451193bc7b51838b1c81
Autor:
Sahil Seth, Chieh-Yuan Li, I-Lin Ho, Denise Corti, Sara Loponte, Luigi Sapio, Edoardo Del Poggetto, Er-Yen Yen, Frederick Scott Robinson, Michael Peoples, Tatiana Karpinets, Angela Kay Deem, Tapsi Kumar, Xingzhi Song, Shan Jiang, Ya’an Kang, Jason Fleming, Michael Kim, Jianhua Zhang, Anirban Maitra, Timothy Paul Heffernan, Virginia Giuliani, Giannicola Genovese, Andrew Futreal, Giulio Francesco Draetta, Alessandro Carugo, Andrea Viale
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1518-1532.e9 (2019)
Summary: Adaptive drug-resistance mechanisms allow human tumors to evade treatment through selection and expansion of treatment-resistant clones. Here, studying clonal evolution of tumor cells derived from human pancreatic tumors, we demonstrate that
Externí odkaz:
https://doaj.org/article/30566401e39148a182c3531e4ef7960d
Autor:
Alessandro Carugo, Giannicola Genovese, Sahil Seth, Luigi Nezi, Johnathon Lynn Rose, Daniela Bossi, Angelo Cicalese, Parantu Krushnakant Shah, Andrea Viale, Piergiorgio Francesco Pettazzoni, Kadir Caner Akdemir, Christopher Aaron Bristow, Frederick Scott Robinson, James Tepper, Nora Sanchez, Sonal Gupta, Marcos Roberto Estecio, Virginia Giuliani, Gaetano Ivan Dellino, Laura Riva, Wantong Yao, Maria Emilia Di Francesco, Tessa Green, Carolina D’Alesio, Denise Corti, Ya’an Kang, Philip Jones, Huamin Wang, Jason Bates Fleming, Anirban Maitra, Pier Giuseppe Pelicci, Lynda Chin, Ronald Anthony DePinho, Luisa Lanfrancone, Timothy Paul Heffernan, Giulio Francesco Draetta
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 133-147 (2016)
Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery appro
Externí odkaz:
https://doaj.org/article/f92a64bf21474917a1f9f089f11ae0b4
Autor:
Ines Martin-Padura, Paola Marighetti, Giuliana Gregato, Alice Agliano, Omar Malazzi, Patrizia Mancuso, Giancarlo Pruneri, Andrea Viale, Francesco Bertolini
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 11, Pp 1057-1066 (2012)
Cell fusion plays a well-recognized physiological role during development, while its function during progression is still unclear. Here, we show that acute myeloid leukemia (AML) cells spontaneously fused with murine host cells in vivo. AML cells fus
Externí odkaz:
https://doaj.org/article/e4e4e231a75947adbc80ef8954e156dc
Autor:
Andrea Viale, Colin R. McInnes
Publikováno v:
Advances in Space Research. 71:604-623
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58d68582a83c2eda94a8d5328cd9df11
https://doi.org/10.1016/j.asr.2022.10.015
https://doi.org/10.1016/j.asr.2022.10.015
Autor:
Christopher J. Halbrook, Galloway Thurston, Seth Boyer, Cecily Anaraki, Jennifer A. Jiménez, Amy McCarthy, Nina G. Steele, Samuel A. Kerk, Hanna S. Hong, Lin Lin, Fiona V. Law, Catherine Felton, Lorenzo Scipioni, Peter Sajjakulnukit, Anthony Andren, Alica K. Beutel, Rima Singh, Barbara S. Nelson, Fran Van Den Bergh, Abigail S. Krall, Peter J. Mullen, Li Zhang, Sandeep Batra, Jennifer P. Morton, Ben Z. Stanger, Heather R. Christofk, Michelle A. Digman, Daniel A. Beard, Andrea Viale, Ji Zhang, Howard C. Crawford, Marina Pasca di Magliano, Claus Jorgensen, Costas A. Lyssiotis
Publikováno v:
Nature cancer, vol 3, iss 11
Nature Cancer
Nature Cancer
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have been characterized by transcriptional and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1d8ab8d7e4958d9992ca11db28b89
https://doi.org/10.1038/s43018-022-00463-1
https://doi.org/10.1038/s43018-022-00463-1