SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

Autor: Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss

Publikováno v: mBio, Vol 13, Iss 5 (2022)

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed over 6 million individuals worldwide and continues to spread in countries where vaccines are not yet widely available or its citizens are hesitant to become vaccinated.

Externí odkaz: https://doaj.org/article/5cf75b97da964ea0a46a9ad54694937e

Analysis of Gene Expression Heterogeneity Reveals Therapeutic Targets and Novel Regulators of Metastasis

Autor: Dongbo Yang, Christopher Dann, Andrea Valdespino, Lydia Robinson-Mailman, Madeline Henn, Mengje Chen, Gábor Balázsi, Marsha Rich Rosner

Tumor cell heterogeneity has been implicated in metastatic progression of solid tumors such as triple-negative breast cancer (TNBC), leading to resistance and recurrence. We hypothesized that genes with low cell-to-cell transcriptional variability ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfaf414f0f942d6226f2fd3edbbb8dba
https://doi.org/10.1101/2022.12.16.520816

Abstract 4807: BACH1 proline hydroxylation regulates the hypoxia response and metastasis in triple negative breast cancer

Autor: Long Chi Nguyen, Christopher Dann, Dongbo Yang, Emily Shi, Thomas Li, Joseph Wynne, Letícia Stock, Madeline Henn, Zeyu Qiao, Andrea Valdespino, Raven Watson, Wenchao Liu, Lydia Robinson-Mailman, Galina Khramtsova, Mitsuyo Matsumoto, Raymond Moellering, Olufunmilayo I. Olopade, Kazuhiko Igarashi, Marsha R. Rosner

Publikováno v: Cancer Research. 83:4807-4807

Hypoxia is an important hallmark of aggressive solid tumors. Here we show that the pro-metastatic BTB and CNC homology 1 (BACH1) transcription factor is prolyl-hydroxylated by the HIF Prolyl Hydroxylase 1 (PHD1) in an oxygen-dependent manner. Using m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a23e4937d1431c7dd680c9bd8fb24f14
https://doi.org/10.1158/1538-7445.am2023-4807

Abstract 118: BACH1 is an oxygen-sensitive mediator of the hypoxia response in triple-negative breast cancer

Autor: Christopher M. Dann, Long C. Nguyen, Dongbo Yang, Joseph P. Wynne, Andrea Valdespino, Letícia Stock, Marsha R. Rosner

Publikováno v: Cancer Research. 82:118-118

Triple-negative breast cancer (TNBC) is an aggressive solid tumor characterized by a hypoxic phenotype that promotes metastatic progression and resistance to therapy. The canonical cellular response to hypoxia is largely driven by hypoxia inducible f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea7c22c571a3d868169b623e4e70b482
https://doi.org/10.1158/1538-7445.am2022-118

Limited inhibition of multiple nodes in a driver network blocks metastasis

Autor: Lydia Robinson-Mailman, Casey Frankenberger, Timothy J. Stuhlmiller, Ali Ekrem Yesilkanal, Jiyoung Lee, Marsha Rich Rosner, Long Chi Nguyen, Gary L. Johnson, Christopher Dann, Xiao-He Xie, Dongbo Yang, Ethan Steinberg, Andrea Valdespino, Alexandre F. Ramos, Siqi Sun, Payal Tiwari, Elizabeth J. Goldsmith, Alan U. Sabino

Publikováno v: eLife
eLife, Vol 10 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d2579ece345e1a678613078c66ce5
https://pubmed.ncbi.nlm.nih.gov/33973518