Výsledky vyhledávání - "Andrea Uecker"

Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents

Autor: Thomas Beckers, Frank-D. Böhmer, Daniel Hägerstrand, Siavosh Mahboobi, Marit Sicker, Arne Östman, Andrea Uecker

Publikováno v: Anti-Cancer Drugs. 21:759-765

Combined treatment with tyrosine kinase inhibitors (TKi) and additional drugs is emerging as a promising strategy for cancer therapy. TKi and histone-deacetylase inhibitors (HDI) are two classes of anti-tumor agents with distant mechanisms of action.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a302a72a3703d08297b600b2a16c3c01
https://doi.org/10.1097/cad.0b013e32833ccf25

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EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332

Autor: Hartwig Kosmehl, Angela Berndt, Petra Richter, Andrea Uecker, Alexander Berndt, Claudia Umbreit, Susanne Grimm, Frank-D. Böhmer, Marcus Franz

Publikováno v: Journal of Oral Pathology & Medicine. 40:46-54

J Oral Pathol Med (2011) 40: 46–54 Epithelial–mesenchymal transition (EMT) is suggested to be crucial for the development of an invasive and metastatic carcinoma cell phenotype. Therefore, the definition of this phenotype is of great clinical int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddab6f68b9934c692f69cfc4cd40dc87
https://doi.org/10.1111/j.1600-0714.2010.00936.x

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Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole

Autor: Andrea Uecker, Andreas Sellmer, Sigurd Elz, Frank-D. Böhmer, Siavosh Mahboobi, Asma Eswayah

Publikováno v: European Journal of Medicinal Chemistry. 43:1444-1453

A series of N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides were synthesized and tested for inhibition of PDGFR and FLT3 autophosphorylation. The novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides, obtained by replacement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0f7e0879dc010da4af39eeb5c0618f
https://doi.org/10.1016/j.ejmech.2007.09.021

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Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis

Autor: Laura Borsi, Katja Grün, Michael Kiehntopf, Alexander Berndt, Hartwig Kosmehl, Andreas Müller, Frank-D. Böhmer, Elisabeth Buchdunger, Andrea Uecker, Carola Leipner, Tobias Janik

Publikováno v: Cardiovascular Research. 79:118-126

Aims Coxsackievirus B3 (CVB3)-induced chronic myocarditis in mice is accompanied by severe fibrosis and by sustained elevation of platelet-derived growth factor (PDGF)-A, -B, and -C levels in the cardiac tissue. To test if PDGF stimulation of residen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035b718a77df13b09005c35bbf1424cc
https://doi.org/10.1093/cvr/cvn063

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Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Autor: Stefan Dove, Christophe Cénac, Siavosh Mahboobi, Harald Hufsky, Florian H. Heidel, Thomas Fischer, Andreas Sellmer, Emerich Eichhorn, Herwig Pongratz, Andrea Uecker, Frank-D. Böhmer, Heymo Höcher, Sigurd Elz, Antje Trümpler, Marit Sicker, Carol Stocking

Publikováno v: Journal of Medicinal Chemistry. 49:3101-3115

FLT3 receptor tyrosine kinase is aberrantly active in many cases of acute myeloid leukemia (AML). Recently, bis(1H-indol-2-yl)methanones were found to inhibit FLT3 and PDGFR kinases. To optimize FLT3 activity and selectivity, 35 novel derivatives wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3140052203ccaad4e6f24334c51ad99
https://doi.org/10.1021/jm058033i

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EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332

Autor: Petra, Richter, Claudia, Umbreit, Marcus, Franz, Angela, Berndt, Susanne, Grimm, Andrea, Uecker, Frank D, Böhmer, Hartwig, Kosmehl, Alexander, Berndt

Publikováno v: Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 40(1)

Epithelial-mesenchymal transition (EMT) is suggested to be crucial for the development of an invasive and metastatic carcinoma cell phenotype. Therefore, the definition of this phenotype is of great clinical interest. We recently evidenced vimentin p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75e19de41c52f47106e1e2db84239dc2
https://pubmed.ncbi.nlm.nih.gov/20819124

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Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model

Autor: Alexander Berndt, Oliver Mutschke, Gerald S. Werner, Andrea Uecker, Siavosh Mahboobi, Ronny Platz, Enrico Jandt, Hans R. Figulla, Frank-D. Böhmer

Publikováno v: Vascular pharmacology. 52(1-2)

Long-term success of modern therapies for myocardial ischemia is limited by restenosis, with proliferation and migration of vascular smooth muscle cells (VSMC) as key events. Since findings in recent years indicate, that the Platelet Derived Growth F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37e4a31d8b09f7104f12850a5cf731a
https://pubmed.ncbi.nlm.nih.gov/19951743

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A substrate peptide for the FLT3 receptor tyrosine kinase

Autor: Frank-D. Böhmer, Andrea Uecker

Publikováno v: British journal of haematology. 144(1)

FLT3 (fms-like tyrosine kinase 3) is frequently activated by mutation in acute myeloid leukemia, and is therefore under study as a drug target. Testing and characterization of tyrosine kinase inhibitors is facilitated by the availability of efficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377ce5277a1b662cb598978500e84ff4
https://pubmed.ncbi.nlm.nih.gov/19016738

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Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones

Autor: Sigurd Elz, Christophe Cénac, Emerich Eichhorn, Siavosh Mahboobi, Stefan Dove, Frank-D. Böhmer, Andrea Uecker, Andreas Sellmer

Publikováno v: Bioorganicmedicinal chemistry. 15(5)

A series of bis(benzo[b]furan-2-yl)methanones was synthesized and tested for inhibition of FLT3 and PDGFR autophosphorylation. Mostly, C-5 substitution leads to PDGFR selectivity, which was strongest in the case of the 5,5'-dimethoxy derivative. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b6a5e235e0b2293bb7a85d74bab8ee
https://pubmed.ncbi.nlm.nih.gov/17210255

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