Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andrea Tobler"'
Publikováno v:
Research Developments in Medicine and Medical Science Vol. 4 ISBN: 9788119102334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d5caab204662d8f38c32e49b3ae1cb7
https://doi.org/10.9734/bpi/rdmms/v4/3474a
https://doi.org/10.9734/bpi/rdmms/v4/3474a
Publikováno v:
International Journal of Clinical Pharmacy. 38:303-309
Background Total serum drug levels are routinely determined for the therapeutic drug monitoring of selected, difficult-to-dose drugs. For some of these drugs, however, knowledge of the free fraction is necessary to adapt correct dosing. Phenytoin, wi
Publikováno v:
Hösli, Raphael; Tobler, Andrea; König, Stefan; Mühlebach, Stefan (2013). A quantitative phenytoin GC-MS method and it's validation for samples from human ex situ brain microdialysis, blood and saliva using solid-phase extraction. Journal of analytical toxicology, 37(2), pp. 102-109. Oxford University Press 10.1093/jat/bks137
This study describes the development and validation of a gas chromatography-mass spectrometry (GC-MS) method to identify and quantitate phenytoin in brain microdialysate, saliva and blood from human samples. A solid-phase extraction (SPE) was perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7e36f63ac38aa88b745fd19235cac
http://doc.rero.ch/record/289843/files/bks137.pdf
http://doc.rero.ch/record/289843/files/bks137.pdf
Autor:
Andrea Tobler, Stefan Mühlebach
Publikováno v:
International Journal of Clinical Pharmacy. 35:790-797
Background In the hospital, medication management for effective antiepileptic therapy with phenytoin (PHT) often needs rapid IV loading and subsequent dose adjustment according to therapeutic drug monitoring (TDM). Objective To investigate PHT perfor