CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

Autor: Andrea Timpanaro, Caroline Piccand, Dzhangar Dzhumashev, Stenija Anton-Joseph, Andrea Robbi, Janine Moser, Jochen Rössler, Michele Bernasconi

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-30 (2023)

Abstract Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic, high-grade, and relapsed RMS. New treatments are urgently needed, especially systemic therapies.

Externí odkaz: https://doaj.org/article/eba3d6375e904fe5b2a50514e336fecc

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

Autor: L'Houcine Ouafik, Roberto Bosotti, D. Albino, Alyssa Paganoni, Simona Rossi, Martina Marchetti, Esteban Cvitkovic, Shusil Pandit, Giuseppina M. Carbone, Gianluca Civenni, Maria E. Riveiro, Abhishek Mitra, Martina Giurdanella, Marco Losa, Carlo V. Catapano, Sarah N. Mapelli, Sarah Mackenzie, Ramiro Vázquez, Keyvan Rezai, Gioacchino D'Ambrosio, Sara Allegrini, Diego Morone, Andrea Rinaldi, Andrea Timpanaro, Jessica Merulla, Luca Vierling, Enrica Mira-Catò, Rocco D'Antuono

Publikováno v: Cell Metabolism
Cell Metabolism, 2019, 30 (2), pp.303-318.e6. ⟨10.1016/j.cmet.2019.05.004⟩
Cell Metabolism, Elsevier, 2019, 30 (2), pp.303-318.e6. ⟨10.1016/j.cmet.2019.05.004⟩

International audience; Cancer stem cells (CSCs) contribute to disease progression and treatment failure in human cancers. The balance among self-renewal, differentiation, and senescence determines the expansion or progressive exhaustion of CSCs. Tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07433ac2a228a36fec1998a862422be
https://hal-amu.archives-ouvertes.fr/hal-02483099