Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial

Autor: Wesley H, Self, Matthew W, Semler, Lindsay M, Leither, Jonathan D, Casey, Derek C, Angus, Roy G, Brower, Steven Y, Chang, Sean P, Collins, John C, Eppensteiner, Michael R, Filbin, D Clark, Files, Kevin W, Gibbs, Adit A, Ginde, Michelle N, Gong, Frank E, Harrell, Douglas L, Hayden, Catherine L, Hough, Nicholas J, Johnson, Akram, Khan, Christopher J, Lindsell, Michael A, Matthay, Marc, Moss, Pauline K, Park, Todd W, Rice, Bryce R H, Robinson, David A, Schoenfeld, Nathan I, Shapiro, Jay S, Steingrub, Christine A, Ulysse, Alexandra, Weissman, Donald M, Yealy, B Taylor, Thompson, Samuel M, Brown, Jay, Steingrub, Howard, Smithline, Bogdan, Tiru, Mark, Tidswell, Lori, Kozikowski, Sherell, Thornton-Thompson, Leslie, De Souza, Peter, Hou, Rebecca, Baron, Anthony, Massaro, Imoigele, Aisiku, Lauren, Fredenburgh, Raghu, Seethala, Lily, Johnsky, Richard, Riker, David, Seder, Teresa, May, Michael, Baumann, Ashley, Eldridge, Christine, Lord, Nathan, Shapiro, Daniel, Talmor, Thomas, O’Mara, Charlotte, Kirk, Kelly, Harrison, Lisa, Kurt, Margaret, Schermerhorn, Valerie, Banner-Goodspeed, Katherine, Boyle, Nicole, Dubosh, Michael, Filbin, Kathryn, Hibbert, Blair, Parry, Kendall, Lavin-Parsons, Natalie, Pulido, Brendan, Lilley, Carl, Lodenstein, Justin, Margolin, Kelsey, Brait, Alan, Jones, James, Galbraith, Rebekah, Peacock, Utsav, Nandi, Taylor, Wachs, Michael, Matthay, Kathleen, Liu, Kirsten, Kangelaris, Ralph, Wang, Carolyn, Calfee, Kimberly, Yee, Gregory, Hendey, Steven, Chang, George, Lim, Nida, Qadir, Andrea, Tam, Rebecca, Beutler, Joseph, Levitt, Jenny, Wilson, Angela, Rogers, Rosemary, Vojnik, Jonasel, Roque, Timothy, Albertson, James, Chenoweth, Jason, Adams, Skyler, Pearson, Maya, Juarez, Eyad, Almasri, Mohamed, Fayed, Alyssa, Hughes, Shelly, Hillard, Ryan, Huebinger, Henry, Wang, Elizabeth, Vidales, Bela, Patel, Adit, Ginde, Amiran, Baduashvili, Jeffrey, McKeehan, Lani, Finck, Carrie, Higgins, Michelle, Howell, Ivor, Douglas, Jason, Haukoos, Terra, Hiller, Carolynn, Lyle, Alicia, Cupelo, Emily, Caruso, Claudia, Camacho, Stephanie, Gravitz, James, Finigan, Christine, Griesmer, Pauline, Park, Robert, Hyzy, Kristine, Nelson, Kelli, McDonough, Norman, Olbrich, Mark, Williams, Raj, Kapoor, Jean, Nash, Meghan, Willig, Henry, Ford, Jayna, Gardner-Gray, Mayur, Ramesh, Montefiore, Moses, Michelle, Ng Gong, Michael, Aboodi, Ayesha, Asghar, Omowunmi, Amosu, Madeline, Torres, Savneet, Kaur, Jen-Ting, Chen, Aluko, Hope, Brenda, Lopez, Kathleen, Rosales, Jee, Young You, Jarrod, Mosier, Cameron, Hypes, Bhupinder, Natt, Bryan, Borg, Elizabeth, Salvagio Campbell, R Duncan, Hite, Kristin, Hudock, Autumn, Cresie, Faysal, Alhasan, Jose, Gomez-Arroyo, Abhijit, Duggal, Omar, Mehkri, Andrei, Hastings, Debasis, Sahoo, Francois, Abi Fadel, Susan, Gole, Valerie, Shaner, Allison, Wimer, Yvonne, Meli, Alexander, King, Thomas, Terndrup, Matthew, Exline, Sonal, Pannu, Emily, Robart, Sarah, Karow, Catherine, Hough, Bryce, Robinson, Nicholas, Johnson, Daniel, Henning, Monica, Campo, Stephanie, Gundel, Sakshi, Seghal, Sarah, Katsandres, Sarah, Dean, Olivia, Krol, Milad, Jouzestani, Peter, Huynh, Donald, Yealy, Denise, Scholl, Peter, Adams, Bryan, McVerry, David, Huang, Derek, Angus, Jordan, Schooler, Steven, Moore, Clark, Files, Chadwick, Miller, Kevin, Gibbs, Mary, LaRose, Lori, Flores, Lauren, Koehler, Caryn, Morse, John, Sanders, Caitlyn, Langford, Kristen, Nanney, Masiku, MdalaGausi, Phyllis, Yeboah, Peter, Morris, Jamie, Sturgill, Sherif, Seif, Evan, Cassity, Sanjay, Dhar, Marjolein, de Wit, Jessica, Mason, Andrew, Goodwin, Greg, Hall, Abbey, Grady, Amy, Chamberlain, Samuel, Brown, Joseph, Bledsoe, Lindsay, Leither, Ithan, Peltan, Nathan, Starr, Melissa, Fergus, Valerie, Aston, Quinn, Montgomery, Rilee, Smith, Mardee, Merrill, Katie, Brown, Brent, Armbruster, Estelle, Harris, Elizabeth, Middleton, Robert, Paine, Stacy, Johnson, Macy, Barrios, John, Eppensteiner, Alexander, Limkakeng, Lauren, McGowan, Tedra, Porter, Andrew, Bouffler, J. Clancy, Leahy, Bennet, deBoisblanc, Matthew, Lammi, Kyle, Happel, Paula, Lauto, Wesley, Self, Jonathan, Casey, Matthew, Semler, Sean, Collins, Frank, Harrell, Christopher, Lindsell, Todd, Rice, William, Stubblefield, Christopher, Gray, Jakea, Johnson, Megan, Roth, Margaret, Hays, Donna, Torr, Arwa, Zakaria, David, Schoenfeld, Taylor, Thompson, Douglas, Hayden, Nancy, Ringwood, Cathryn, Oldmixon, Christine, Ulysse, Richard, Morse, Ariela, Muzikansky, Laura, Fitzgerald, Samuel, Whitaker, Adrian, Lagakos, Roy, Brower, Lora, Reineck, Neil, Aggarwal, Karen, Bienstock, Michelle, Freemer, Myron, Maclawiw, Gail, Weinmann, Laurie, Morrison, Mark, Gillespie, Richard, Kryscio, Daniel, Brodie, Wojciech, Zareba, Anne, Rompalo, Michael, Boeckh, Polly, Parsons, Jason, Christie, Jesse, Hall, Nicholas, Horton, Laurie, Zoloth, Neal, Dickert, Deborah, Diercks

Publikováno v: JAMA

Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19. Design, Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc7939bb8a665291d7a442936712b96
https://europepmc.org/articles/PMC7653542/

A mitochondrial DNA D loop insertion detected almost exclusively in non-replicating tissues with maternal inheritance across three generations

Autor: Ian R. A. Mackenzie, Andrea Tam, Hélène C. F. Côté, Ja Young J. Lee, Hilary Vallance, Mehul Sharma, Sandra Sirrs, Andre Mattman, Fady Hannah-Shmouni, Beheroze Sattha

Publikováno v: Mitochondrion. 46

Muscle biopsy identified a possibly pathogenic, mitochondrial DNA D-loop insertion, in each of 5 family members from two generations, that was otherwise undetectable in most other tissues. The tissue specific regulation of heteroplasmy is reflected i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567298f3ca59b6c2c0acdbd0831d0836
https://pubmed.ncbi.nlm.nih.gov/30114489

Drug-Sensitive DNA Polymerase δ Reveals a Role for Mismatch Repair in Checkpoint Activation in Yeast

Autor: Md. Shahjahan P. Siddique, Sam Lou, Charles Boone, Michelle O’Carroll, Kelly Murphy, Andrea Tam, Amy Schultz, Linda J. Reha-Krantz

Publikováno v: Genetics. 189:1211-1224

We have used a novel method to activate the DNA damage S-phase checkpoint response in Saccharomyces cerevisiae to slow lagging-strand DNA replication by exposing cells expressing a drug-sensitive DNA polymerase δ (L612M-DNA pol δ) to the inhibitory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfbfe99bdda527a89f9b9dce8382f1e
https://doi.org/10.1534/genetics.111.131938

Epoxy Sepabeads: A Novel Epoxy Support for Stabilization of Industrial Enzymes via Very Intense Multipoint Covalent Attachment

Autor: Gloria Fernández-Lorente, Justo Pedroche, Cesar Mateo, Jose M. Guisan, Roberto Fernandez-Lafuente, Moreno Daminati, Andrea Tam, Olga Abian

Publikováno v: Biotechnology Progress. 18:629-634

Sepabeads-EP (a new epoxy support) has been utilized to immobilize-stabilize the enzyme penicillin G acylase (PGA) via multipoint covalent attachment. These supports are very robust and suitable for industrial purposes. Also, the internal geometry of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32294a92d83b12810e5d9c1b8af71f7c
https://doi.org/10.1021/bp010171n

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

Autor: Marion Darnaud, Filipe De Vadder, Pascaline Bogeat, Lilia Boucinha, Anne-Laure Bulteau, Andrei Bunescu, Céline Couturier, Ana Delgado, Hélène Dugua, Céline Elie, Alban Mathieu, Tereza Novotná, Djomangan Adama Ouattara, Séverine Planel, Adrien Saliou, Dagmar Šrůtková, Jennifer Yansouni, Bärbel Stecher, Martin Schwarzer, François Leulier, Andrea Tamellini

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobioti

Externí odkaz: https://doaj.org/article/ad2f54703d4e4a40b40755a7d77374ec