Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Andrea Sturchio"'
Autor:
Ellen Appleton, Shervin Khosousi, Michael Ta, Michael Nalls, Andrew B. Singleton, Andrea Sturchio, Ioanna Markaki, Wojciech Paslawski, Hirotaka Iwaki, Per Svenningsson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/2452f35a07f14ef3a8a8f025c9d8bf2d
Autor:
Andrea Sturchio, Emily M. Rocha, Marcelo A. Kauffman, Luca Marsili, Abhimanyu Mahajan, Ameya A. Saraf, Joaquin A. Vizcarra, Ziyuan Guo, Alberto J. Espay
Publikováno v:
Brain Sciences, Vol 14, Iss 2, p 151 (2024)
Animal models have been used to gain pathophysiologic insights into Parkinson’s disease (PD) and aid in the translational efforts of interventions with therapeutic potential in human clinical trials. However, no disease-modifying therapy for PD has
Externí odkaz:
https://doaj.org/article/f172463d7e0e4ec7abae20cf0d6114dd
Autor:
Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir EL Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Publikováno v:
EClinicalMedicine, Vol 38, Iss , Pp 100988- (2021)
Background: Brain amyloidosis does not invariably predict dementia. We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis. Me
Externí odkaz:
https://doaj.org/article/c2d3152bfc424c28a2d7b817f273be9a
Publikováno v:
Biology, Vol 11, Iss 4, p 535 (2022)
Protein aggregation into amyloid fibrils affects many proteins in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer. Physicochemically, amyloid formation is a phase transition process, where soluble proteins are trans
Externí odkaz:
https://doaj.org/article/c8f704fbaec946ceb2160cc2d398874e
Autor:
Andrea Sturchio, Luca Marsili, Joaquin A. Vizcarra, Alok K. Dwivedi, Marcelo A. Kauffman, Andrew P. Duker, Peixin Lu, Michael W. Pauciulo, Benjamin D. Wissel, Emily J. Hill, Benjamin Stecher, Elizabeth G. Keeling, Achala S. Vagal, Lily Wang, David B. Haslam, Matthew J. Robson, Caroline M. Tanner, Daniel W. Hagey, Samir El Andaloussi, Kariem Ezzat, Ronan M. T. Fleming, Long J. Lu, Max A. Little, Alberto J. Espay
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Ongoing biomarker development programs have been designed to identify serologic or imaging signatures of clinico-pathologic entities, assuming distinct biological boundaries between them. Identified putative biomarkers have exhibited large variabilit
Externí odkaz:
https://doaj.org/article/6d424a4d86364f5683f8e545b0af57fb
Autor:
Abhimanyu Mahajan, Martina Chirra, Alok K. Dwivedi, Andrea Sturchio, Elizabeth G. Keeling, Luca Marsili, Alberto J. Espay
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Objective: To evaluate the extent to which cancer, a biological opposite to neurodegenerative disorders, may affect the onset and progression of Parkinson's disease (PD).Methods: A nested case-control design in consecutive PD patients with (cases) vs
Externí odkaz:
https://doaj.org/article/c1f853c5ea034834ac6a3c9e02831d47
Autor:
Maja Malmberg, Tarja Malm, Oskar Gustafsson, Andrea Sturchio, Caroline Graff, Alberto J. Espay, Anthony P. Wright, Samir El Andaloussi, Anders Lindén, Kariem Ezzat
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Amyloids are fibrillar protein aggregates associated with diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid polymerization involves three pathological pro
Externí odkaz:
https://doaj.org/article/c0de4b45af114fe98c89ab07e25909a6
Autor:
Natasa Kustrimovic, Cristoforo Comi, Luca Magistrelli, Emanuela Rasini, Massimiliano Legnaro, Raffaella Bombelli, Iva Aleksic, Fabio Blandini, Brigida Minafra, Giulio Riboldazzi, Andrea Sturchio, Marco Mauri, Giorgio Bono, Franca Marino, Marco Cosentino
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)
Abstract Background Parkinson’s disease (PD) affects an estimated 7 to 10 million people worldwide, and only symptomatic treatments are presently available to relieve the consequences of brain dopaminergic neurons loss. Neuronal degeneration in PD
Externí odkaz:
https://doaj.org/article/d5ef83359b5342929d77e3b2d87b9ae6
Autor:
Luca Marsili, Jennifer Sharma, Alberto J. Espay, Alice Migazzi, Elhusseini Abdelghany, Emily J. Hill, Kevin R. Duque, Matthew C. Hagen, Christopher D. Stephen, Gabor G. Kovacs, Anthony E. Lang, Marios Hadjivassiliou, Manuela Basso, Marcelo A. Kauffman, Andrea Sturchio
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7292 (2021)
The gold standard for classification of neurodegenerative diseases is postmortem histopathology; however, the diagnostic odyssey of this case challenges such a clinicopathologic model. We evaluated a 60-year-old woman with a 7-year history of a progr
Externí odkaz:
https://doaj.org/article/7ae52b70500343c29f13e64ded63079a
Autor:
Danielle te Vruchte, Andrea Sturchio, David A. Priestman, Panagiota Tsitsi, Ellen Hertz, Mattias Andréasson, Ioanna Markaki, Kerri‐Lee Wallom, Frances Platt, Per Svenningsson
Publikováno v:
Movement Disorders. 37:2129-2134
Alteration in glycosphingolipids (GSLs) in Parkinson's disease (PD) still needs to be determined.We evaluated if PD subjects show abnormal GSLs levels compared to healthy controls (HC) and if GSLs correlate with clinical features.We analyzed GSLs and