Neural activity regulates autoimmune diseases through the gateway reflex

Autor: Andrea Stofkova, Masaaki Murakami

Publikováno v: Bioelectronic Medicine, Vol 5, Iss 1, Pp 1-15 (2019)

Abstract The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB) and blood-retina barrier (BRB) respectively, which create a physical interface that tightly control

Externí odkaz: https://doaj.org/article/337810c0e0d5467b8fd0fb9bc2dec004

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Autor: Yasunobu Arima, Daisuke Kamimura, Toru Atsumi, Masaya Harada, Tadafumi Kawamoto, Naoki Nishikawa, Andrea Stofkova, Takuto Ohki, Kotaro Higuchi, Yuji Morimoto, Peter Wieghofer, Yuka Okada, Yuki Mori, Saburo Sakoda, Shizuya Saika, Yoshichika Yoshioka, Issei Komuro, Toshihide Yamashita, Toshio Hirano, Marco Prinz, Masaaki Murakami

Publikováno v: eLife, Vol 4 (2015)

Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that

Externí odkaz: https://doaj.org/article/0ec4e6b57e8942279410c29febe81f79

Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex

Autor: Andrea Stofkova, Miloslav Zloh, Dominika Andreanska, Ivana Fiserova, Jan Kubovciak, Jan Hejda, Patrik Kutilek, Masaaki Murakami

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 453
International Journal of Molecular Sciences, Vol 23, Iss 453, p 453 (2022)

The gateway reflex is a mechanism by which neural inputs regulate chemokine expression at endothelial cell barriers, thereby establishing gateways for the invasion of autoreactive T cells into barrier-protected tissues. In this study, we hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe11f28314dadbeda1e4c7cc731fc68
https://pubmed.ncbi.nlm.nih.gov/35008877

High-Contrast Stimulation Potentiates the Neurotrophic Properties of Müller Cells and Suppresses Their Pro-Inflammatory Phenotype

Autor: Miloslav Zloh, Patrik Kutilek, Andrea Stofkova

Publikováno v: International Journal of Molecular Sciences. 23:8615

High-contrast visual stimulation promotes retinal regeneration and visual function, but the underlying mechanism is not fully understood. Here, we hypothesized that Müller cells (MCs), which express neurotrophins such as brain-derived neurotrophic f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a22e862007f90381b30268247b3ca2
https://doi.org/10.3390/ijms23158615

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells

Autor: Jing-Jing Jiang, Masaaki Murakami, Naoki Nishikawa, Lavannya Sabharwal, Yasunobu Arima, Mineko Tsuruoka, Andrea Stofkova, Jie Meng, Hideki Ogura, Toru Atsumi, Hidenori Bando, Daisuke Kamimura, Kotaro Higuchi

Publikováno v: International Immunology. 28:117-126

KDEL receptor 1 (KDELR1) regulates integrated stress responses (ISR) to promote naive T-cell survival in vivo . In a mouse line having nonfunctional KDELR1, T-Red (naive T-cell reduced) mice, polyclonal naive T cells show excessive ISR and eventually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a363a410661991091c8b0855e6498fbe
https://doi.org/10.1093/intimm/dxv059