Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Andrea Schiefer"'
Autor:
Jacqueline T. Balthazar, Daniel Golparian, Magnus Unemo, Timothy D. Read, Miriam Grosse, Marc Stadler, Kenneth Pfarr, Andrea Schiefer, Achim Hoerauf, Jennifer L. Edwards, Dmitry G. Vassylyev, William M. Shafer
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/6b803d30307d4d6083f7d0b1b866983c
Autor:
Lara Vanessa Behrmann, Kirstin Meier, Jennifer Vollmer, Chukwuebuka Chibuzo Chiedu, Andrea Schiefer, Achim Hoerauf, Kenneth Pfarr
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Obligate intracellular endobacteria of the genus Wolbachia are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy with antibiotics are based on this im
Externí odkaz:
https://doaj.org/article/03368d811bd94d038074d4ec846c278c
Autor:
Jacqueline T. Balthazar, Daniel Golparian, Magnus Unemo, Timothy D. Read, Miriam Grosse, Marc Stadler, Kenneth Pfarr, Andrea Schiefer, Achim Hoerauf, Jennifer L. Edwards, Dmitry G. Vassylyev, William M. Shafer
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT The continued emergence of Neisseria gonorrhoeae strains that express resistance to multiple antibiotics, including the last drug for empiric monotherapy (ceftriaxone), necessitates the development of new treatment options to cure gonorrheal
Externí odkaz:
https://doaj.org/article/48b85a00acda464f9f62ce8110ea29d7
Autor:
Iris Löckener, Lara Vanessa Behrmann, Jula Reuter, Andrea Schiefer, Anna Klöckner, Sebastian Krannich, Christian Otten, Katja Mölleken, Satoshi Ichikawa, Achim Hoerauf, Tanja Schneider, Kenneth M. Pfarr, Beate Henrichfreise
Publikováno v:
Antibiotics, Vol 13, Iss 5, p 421 (2024)
Chlamydial infections and diseases caused by filarial nematodes are global health concerns. However, treatment presents challenges due to treatment failures potentially caused by persisting Chlamydia and long regimens against filarial infections acco
Externí odkaz:
https://doaj.org/article/92030dcf073649b2808790b4e071297e
Autor:
Tim Becker, Jan Heitkötter, Anna K. Krome, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Miriam Grosse, Birthe Sandargo, Ingo Stammberger, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 386 (2024)
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for or
Externí odkaz:
https://doaj.org/article/67c81d037ce842dc8ccd3f679297af6f
Autor:
Jennifer L. Edwards, Jacqueline T. Balthazar, Danillo L. A. Esposito, Julio C. Ayala, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Silke Alt, Thomas Hesterkamp, Miriam Grosse, Marc Stadler, Daniel Golparian, Magnus Unemo, Timothy D. Read, William M. Shafer
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Gonorrhea remains a major global public health problem because of the high incidence of infection (estimated 82 million cases in 2020) and the emergence and spread of Neisseria gonorrhoeae strains resistant to previous and current antibiotic
Externí odkaz:
https://doaj.org/article/961e129f07f64b2fb61e13b4c0e7ef00
Autor:
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. König, Anna K. Krome, Marc P. Hübner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 131 (2022)
Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths worldwide in 2019. Thus, there is an unmet medical need for novel and resistance-breaking anti-i
Externí odkaz:
https://doaj.org/article/edb4852a2b3245799a4221b686948f81
Autor:
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluatio
Externí odkaz:
https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b
Autor:
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 920 (2022)
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S. aureus using fluctuat
Externí odkaz:
https://doaj.org/article/f755728120db4450ac61d370364e0082
Autor:
Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m
Externí odkaz:
https://doaj.org/article/d4370a71cad149209e66761eb918df85