Afatinib as first-line treatment in patients with -mutated non-small cell lung cancer in routine clinical practice

Autor: Wolfgang M. Brückl, Martin Reck, Frank Griesinger, Harald Schäfer, Cornelius Kortsik, Tobias Gaska, Justyna Rawluk, Stefan Krüger, Konrad Kokowski, Stephan Budweiser, Joachim H. Ficker, Christopher Hoffmann, Andrea Schüler, Eckart Laack

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)

Background: Lung cancer is a leading cause of cancer-related death in Germany and worldwide. Non-small cell lung cancer (NSCLC) comprises ~80% of lung cancer diagnoses; in White patients, around 10% of NSCLC cases are epidermal growth factor receptor

Externí odkaz: https://doaj.org/article/ed0a49a21806468b8eeae86252f9ad54

Supplementary Figure 2 from STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2

Autor: Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam

PDF file - 626K, Leukemia phenotype (FACS, immunohistochemistry)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1d304c34009c0d5c809aa1a6c47f5a
https://doi.org/10.1158/0008-5472.22394621

Supplementary Methods, Figure Legends 1-4 from STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2

Autor: Thomas Kindler, D. Gary Gilliland, Lothar Hennighausen, Gertraud W. Robinson, Andreas Kreft, Daniel Sasca, Ernesto Bockamp, Gerlinde Wernig, Thomas Mercher, Glen Raffel, Saskia V. Pante, Nan Zhu, Rachel Okabe, Benjamin H. Lee, Andrea Schüler, Patricia S. Hähnel, Winnie F. Tam

PDF file - 91K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132906b3dffc6b6f315cc292e6ea52ff
https://doi.org/10.1158/0008-5472.22394612.v1

Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis

Autor: Lisa Spiecker, Daniel Sasca, Andrea Schüler, Piyush More, Ines Witte, Victoria Petermann, Markus Meyerhöfer, Julia Mehlig, Viral N. Shah, Nina Cabezas-Wallscheid, Thomas Kindler, Andreas Daiber, Sven Horke, Andrea Pautz, Hartmut Kleinert, Patricia S. Haehnel

Publikováno v: Oxidative medicine and cellular longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity

Background. Long-term hematopoietic stem cells (LT-HSCs) reside in bone marrow niches with tightly controlled reactive oxygen species (ROS) levels. ROS increase results into LT-HSC differentiation and stem cell exhaustion. Paraoxonase 2 (PON2) has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe25f2205b615c3bfa97ab916451dd6
https://doi.org/10.1155/2021/3917028

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Autor: Viral Shah, Wolf Henning Gebhardt, George Reid, Patricia S. Haehnel, Oliver Kriege, Lars Bullinger, Claudia Scholl, Anna Dolnik, Daniel Sasca, Eva-Marie Fehr, Matthias Theobald, Jakub Szybinski, Thomas Kindler, Andrea Schüler, Petra Beli, Jan B. Heidelberger

Publikováno v: Blood. 133(21)

Neural cell adhesion molecule 1 (NCAM1; CD56) is expressed in up to 20% of acute myeloid leukemia (AML) patients. NCAM1 is widely used as a marker of minimal residual disease; however, the biological function of NCAM1 in AML remains elusive. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff73b2dfb4b5e7c16f26d7c9ee6a2c
https://pubmed.ncbi.nlm.nih.gov/31122937