Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

Autor: Andrea S Heimann, Achla Gupta, Ivone Gomes, Rahman Rayees, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187306 (2017)

The N-terminal region of G protein-coupled receptors can be efficiently targeted for the generation of receptor-selective antibodies. These antibodies are useful for the biochemical characterization of the receptors. In this study, we developed a set

Externí odkaz: https://doaj.org/article/a02462ed03164899bafd13870378401e

Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice

Autor: Renata Silvério, Robson Barth, Andrea S. Heimann, Patrícia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermúdez-Silva, Alex Rafacho, Emer S. Ferro

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4082

Peptide DIIADDEPLT (Pep19) has been previously suggested to improve metabolic parameters, without adverse central nervous system effects, in a murine model of diet-induced obesity. Here, we aimed to further evaluate whether Pep19 oral administration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048ec784b203e9c960ca830fcbbdd0e5
https://hdl.handle.net/10668/21149

NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration

Autor: Leandro M. Castro, Andrea S. Heimann, Carolina Demarchi Munhoz, Morena Brazil Sant'Anna, Gisele Picolo, Emer S. Ferro, Mayara C. F. Gewehr, Ricardo A. Remer, Aline Carolina Giardini, Nilton Barreto dos Santos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2020-12-10T19:53:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-16 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca557462ef2adc5be629bf5282bf3957

Hemopressin as a breakthrough for the cannabinoid field

Autor: Lakshmi L. Devi, Ricardo Augusto de Melo Reis, Ami Navon, Michal A. Shmuelov, Ivone Gomes, Francisco Silveira Guimarães, Andrea S. Heimann, Camila Squarzoni Dale, Emer S. Ferro, Vanessa Rioli

Publikováno v: Neuropharmacology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Hemopressin (PVNFKFLSH in rats, and PVNFKLLSH in humans and mice), a fragment derived from the α-chain of hemoglobin, was the first peptide described to have type 1 cannabinoid receptor activity. While hemopressin was shown to have inverse agonist/a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c1330de9d9b8be9eb1cd4a203c419f
https://doi.org/10.1016/j.neuropharm.2020.108406

Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine

Autor: Andrea S. Heimann, Yara Cury, A.C.O. Fernandes, F.C. Machado, Gisele Picolo, Vanessa Zambelli

Publikováno v: British Journal of Pharmacology. 171:961-972

Background and Purpose Crotalphine is an antinociceptive peptide that, despite its opioid-like activity, does not induce some of the characteristic side effects of opioids, and its amino acid sequence has no homology to any known opioid peptide. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3592eb95d9ce11c18b07013845eba7dc
https://doi.org/10.1111/bph.12488