Local cefuroxime tissue concentrations in the hand after single and repeated administration to 16 patients undergoing trapeziectomy: a randomized controlled trial

Autor: Andrea René Jørgensen, Pelle Hanberg, Mats Bue, Charlotte Hartig-Andreasen, Nis Pedersen Jørgensen, Maiken Stilling

Publikováno v: Acta Orthopaedica, Vol 95 (2024)

Background and purpose: The duration of antibiotic coverage in hand tissues during surgery is unknown. We investigated the time the free concentration of cefuroxime was above the minimal inhibitory concentration (fT>MIC) of 4 μg/mL in hand tissues a

Externí odkaz: https://doaj.org/article/936105af458e44d59579179cd7e38f1a

Piperacillin Steady State Concentrations in Target Tissues Relevant for PJI Treatment—A Randomized Porcine Microdialysis Study Comparing Continuous Infusion with Intermittent Short-Term Infusion

Autor: Hans Christian Rasmussen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Elisabeth Krogsgaard Petersen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling, Mats Bue

Publikováno v: Antibiotics, Vol 12, Iss 3, p 577 (2023)

(1) Introduction: Piperacillin is a common antibiotic choice in the treatment of periprosthetic joint infections (PJI) caused by Pseudomonas aeruginosa. The aim of this study was to assess and compare the time with free piperacillin concentration abo

Externí odkaz: https://doaj.org/article/b62a569f61ad4c129cef6e46ed839f5e

Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin: Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis

Autor: Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling, Mats Bue

Publikováno v: Antibiotics, Vol 11, Iss 7, p 910 (2022)

Background: Piperacillin is a central drug in the treatment of Pseudomonas aeruginosa spondylodiscitis. Intermittent short-term infusion (STI) remains standard treatment in most centres, although the application of continuous infusion (CI) has shown

Externí odkaz: https://doaj.org/article/1c61e5aae15040e0855b8a04a86c62b3

Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin:Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis

Autor: Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling, Mats Bue

Publikováno v: Petersen, E K, Hanberg, P, Knudsen, M, Tøstesen, S K, Jørgensen, A R, Öbrink-Hansen, K, Søballe, K, Stilling, M & Bue, M 2022, ' Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin : Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis ', Antibiotics, vol. 11, no. 7, 910 . https://doi.org/10.3390/antibiotics11070910
Antibiotics; Volume 11; Issue 7; Pages: 910

Background: Piperacillin is a central drug in the treatment of Pseudomonas aeruginosa spondylodiscitis. Intermittent short-term infusion (STI) remains standard treatment in most centres, although the application of continuous infusion (CI) has shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677d87e9fdfba05d881a29dabbf95a82
https://pure.au.dk/portal/da/publications/intermittent-shortterm-infusion-vs-continuous-infusion-of-piperacillin(5953db83-9989-4859-84eb-f19a5350242f).html

Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue – A randomised porcine microdialysis study

Autor: N. Pedersen Jørgensen, Maja B. Thomassen, Pelle Hanberg, Maiken Stilling, Andrea René Jørgensen, Mats Bue

Publikováno v: Jørgensen, A R, Hanberg, P, Bue, M, Thomassen, M B, Pedersen Jørgensen, N & Stilling, M 2021, ' Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue – A randomised porcine microdialysis study ', European Journal of Pharmaceutical Sciences, vol. 160, 105754 . https://doi.org/10.1016/j.ejps.2021.105754

This study evaluated target tissue concentrations of double dose cefuroxime administered intravenously as either one 15 min infusion of 3000 mg (Group 1) or two single 15 min infusions of 1500 mg administered 4 h apart (Group 2). Sixteen pigs were ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00f4f93f819d01f8678c90876448936
https://pure.au.dk/portal/da/publications/doubledose-cefuroxime-concentrations-in-bone-synovial-fluid-of-the-knee-joint-and-subcutaneous-adipose-tissue--a-randomised-porcine-microdialysis-study(608981c7-1a3f-4980-8120-1f702c9b5358).html