Výsledky vyhledávání - "Andrea R. Connor"

Akademický článek

The N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.

Autor: Su Ling Leong, Mark G Hinds, Andrea R Connor, David P Smith, Eva Illes-Toth, Chi L L Pham, Kevin J Barnham, Roberto Cappai

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116497 (2015)

α-synuclein (α-syn) is a major component of the intracellular inclusions called Lewy bodies, which are a key pathological feature in the brains of Parkinson's disease patients. The neurotransmitter dopamine (DA) inhibits the fibrillisation of α-sy

Externí odkaz: https://doaj.org/article/3a23dc79d4b44c9fbcd8db32dd53519e

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Akademický článek

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

Autor: Angus M Tester, Jennifer H Cox, Andrea R Connor, Amanda E Starr, Richard A Dean, Xose S Puente, Carlos López-Otín, Christopher M Overall

Publikováno v: PLoS ONE, Vol 2, Iss 3, p e312 (2007)

We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cle

Externí odkaz: https://doaj.org/article/43867c694e834ccb82d6c92d53dbe95f

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Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2)

Autor: Andrea R. Connor, Agnès Noël, Nor Eddine Sounni, Charlotte J. Morrison, Ulrich Eckhard, Georgina S. Butler, Christopher M. Overall

Publikováno v: Matrix Biology. 59:23-38

Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14 (membrane-type 1-matrix metalloproteinase, MT1-MMP) that we identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085b58993f4b26d8269e22eb45c0fc03
https://doi.org/10.1016/j.matbio.2016.07.006

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The crystal structure of amyloid precursor-like protein 2 E2 domain completes the amyloid precursor protein family

Autor: Laila C. Roisman, Roberto Cappai, Mun Joo Chuei, Andrea R Connor, Sen Han

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4)

The amyloid precursor-like protein 2 (APLP2) molecule is a type I transmembrane protein that is crucial for survival, cell-cell adhesion, neuronal development, myelination, cancer metastasis, modulation of metal, and glucose and insulin homeostasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc8f6e3f7643c6b0ce23ef6567cdb8c
https://pubmed.ncbi.nlm.nih.gov/30608876

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Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Autor: Soumya Mukherjee, Roberto Cappai, Blaine R. Roberts, Amber Lothian, Christopher Fowler, Larissa Lago, Catriona McLean, Colin L. Masters, Malcolm K. Horne, Andrea R Connor

Publikováno v: Metallomics : integrated biometal science. 11(1)

Abnormal protein structure and function have been implicated as the toxic species in many diseases including neurodegenerative diseases, such as Parkinson's. One key pathological hallmark in Parkinson's disease is the formation of Lewy bodies, of whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b5cab52d7203c63b7ebfb44dd4d4a4
https://pubmed.ncbi.nlm.nih.gov/30465671

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18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Autor: Christopher C. Rowe, Kazuhiko Yanai, Nobuyuki Okamura, Angela Rigopoulos, Glenn A Cartwright, Yukitsuka Kudo, Victor L. Villemagne, Roberto Cappai, Andrea R Connor, Rachel S. Mulligan, Michelle T. Fodero-Tavoletti, Catriona McLean, Colin L. Masters, Sylvia J. Gong, Shozo Furumoto, Graeme O'Keefe, Kevin J. Barnham, Paul A. Adlard, Diana Cao

Publikováno v: Brain. 134:1089-1100

While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diagnosis of Alzheimer's disease, no radiotracer is available for the non-invasive quantification of tau. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb38407a51b5620db6603981faf093c0
https://doi.org/10.1093/brain/awr038

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Amyloid Imaging in Alzheimer’s Disease and Other Dementias

Autor: Kerryn E. Pike, Andrea R Connor, Tiffany F. Cowie, Michelle T. Fodero-Tavoletti, Catriona McLean, Roberto Cappai, Paul A. Adlard, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne

Publikováno v: Brain Imaging and Behavior. 3:246-261

With the advent of new therapeutic strategies aimed at reducing β-amyloid (Aβ) burden in the brain to potentially prevent or delay functional and irreversible cognitive loss, there is increased interest in developing agents that allow assessment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3922db196d8653e99c45ad330f37609b
https://doi.org/10.1007/s11682-009-9067-2

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In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer

Autor: Roberto Cappai, Michelle T. Fodero-Tavoletti, Victor L. Villemagne, Lucas Martin, Christopher C. Rowe, Andrea R Connor, Andrea Thiele, Thomas Dyrks, Catriona McLean, Damian Brockschnieder, Ludger Dinkelborg, Mathias Berndt, Colin L. Masters, Sabine Krause

Publikováno v: Nuclear medicine and biology. 39(7)

Purpose Amyloid-β (Aβ) plaques are a major pathological hallmark of Alzheimer's disease (AD). The noninvasive detection of Aβ plaques may increase the accuracy of clinical diagnosis as well as monitor therapeutic interventions. While [ 11 C]-PiB i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7add9f56997a30ecb1cdac16397a5d54
https://pubmed.ncbi.nlm.nih.gov/22503458

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