Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrea R. Conlan"'
Autor:
Sagi Tamir, John A Zuris, Lily Agranat, Colin H Lipper, Andrea R Conlan, Dorit Michaeli, Yael Harir, Mark L Paddock, Ron Mittler, Zvi Ioav Cabantchik, Patricia A Jennings, Rachel Nechushtai
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61202 (2013)
Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfr
Externí odkaz:
https://doaj.org/article/784e2a071f1348ef8f98f442fc369770
Autor:
Mark L. Paddock, Ron Mittler, Rachel Nechushtai, Colin H. Lipper, Faruck Morcos, Patricia A. Jennings, Kendra L. Hailey, José N. Onuchic, Andrea R. Conlan, Assaf Friedler, Charles Wang, Chen Katz, John A. Zuris, Shahar Rotem-Bamberger, Sagi Tamir
Publikováno v:
Proceedings of the National Academy of Sciences. 111:5177-5182
Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and lead to an output response. Am
Autor:
Vladimir Shulaev, Luhua Song, Ron Mittler, Sarah H. Holt, Abraham Hochberg, Yang Sung Sohn, Rachel Nechushtai, José N. Onuchic, Andrea R. Conlan, Dorit Michaeli, Yael Harir, Imad Matouk, Sagi Tamir, Ioav Z. Cabanchick, Patricia A. Jennings, Mark L. Paddock
Publikováno v:
Proceedings of the National Academy of Sciences. 110:14676-14681
Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although sever
Autor:
Rachel Rosen, Rachel Nechushtai, Ohad Yogev, Yael Eisenberg-Domovich, Vincent Ma, Luhua Song, Oded Livnah, Yuting Luo, Ron Mittler, Yael Harir, John A. Zuris, Patricia A. Jennings, Zvi Ioav Cabantchik, Mark L. Paddock, Andrea R. Conlan, Dorit Michaeli
Publikováno v:
The Plant Cell. 24:2139-2154
The NEET family is a newly discovered group of proteins involved in a diverse array of biological processes, including autophagy, apoptosis, aging, diabetes, and reactive oxygen homeostasis. They form a novel structure, the NEET fold, in which two pr
Autor:
Mark L. Paddock, José N. Onuchic, Sagi Tamir, Zvi Ioav Cabantchik, Andrea R. Conlan, Dorit Michaeli, Ron Mittler, John A. Zuris, Patricia A. Jennings, Maya Shvartsman, Rachel Nechushtai, Yael Harir
Publikováno v:
Proceedings of the National Academy of Sciences. 108:13047-13052
MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys coordination of mNT’s [2Fe-2S] leads to cluster lability that is strongly de
Autor:
Stefan Stoll, Michelle M. Dicus, Patricia A. Jennings, Rachel Nechushtai, R. David Britt, Andrea R. Conlan, Mark L. Paddock
Publikováno v:
Journal of the American Chemical Society. 132:2037-2049
Human mitoNEET is a homodimeric iron-sulfur protein located in the outer mitochondrial membrane with unknown function, but which is known to interact with thiazolidinedione diabetes drugs. Each monomer houses a [2Fe-2S] cluster with an unusual (Cys)(
Autor:
Rachel Nechushtai, Mark L. Paddock, Andrea R. Conlan, Timothy F. Tirrell, Judy E. Kim, Eric J. Smoll, Patricia A. Jennings
Publikováno v:
Biochemistry. 48:4747-4752
MitoNEET is a 2Fe-2S outer mitochondrial membrane protein that was initially identified as a target for anti-diabetic drugs. It exhibits a novel protein fold, and in contrast to other 2Fe-2S proteins such as Rieske proteins and ferredoxins, the metal
Autor:
Yael Eisenberg-Domovich, Jason T. Stofleth, Ron Mittler, Sagi Tamir, Oded Livnah, Colin H. Lipper, Patricia A. Jennings, Andrea R. Conlan, Mark L. Paddock, Rachel Nechushtai
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 70(Pt 6)
NAF-1 is an important [2Fe–2S] NEET protein associated with human health and disease. A mis-splicing mutation in NAF-1 results in Wolfram Syndrome type 2, a lethal childhood disease. Upregulation of NAF-1 is found in epithelial breast cancer cells,
Autor:
Danny A. Halim, Rachel Nechushtai, John A. Zuris, Mark L. Paddock, Patricia A. Jennings, E. C. Abresch, Andrea R. Conlan
Publikováno v:
Journal of the American Chemical Society
MitoNEET is a newly discovered mitochondrial protein and a target of the TZD class of antidiabetes drugs. MitoNEET is homodimeric with each protomer binding a [2Fe-2S] center through a rare 3-Cys and 1-His coordination geometry. Both the fold and the
Autor:
Rachel Nechushtai, Andrea R. Conlan, Zvi Ioav Cabantchik, Dorit Michaeli, Lily Agranat, Colin H. Lipper, Sagi Tamir, Yael Harir, John A. Zuris, Patricia A. Jennings, Ron Mittler, Mark L. Paddock
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61202 (2013)
PLoS ONE
PLoS ONE
Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfr