Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Andrea R Masters"'
1
Akademický článek
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry
Autor: Gregory G Grecco, Briana E Mork, Jui-Yen Huang, Corinne E Metzger, David L Haggerty, Kaitlin C Reeves, Yong Gao, Hunter Hoffman, Simon N Katner, Andrea R Masters, Cameron W Morris, Erin A Newell, Eric A Engleman, Anthony J Baucum, Jiuen Kim, Bryan K Yamamoto, Matthew R Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L Sheets, Brady K Atwood
Publikováno v: eLife, Vol 10 (2021)
Despite the rising prevalence of methadone treatment in pregnant women with opioid use disorder, the effects of methadone on neurobehavioral development remain unclear. We developed a translational mouse model of prenatal methadone exposure (PME) tha
Externí odkaz: https://doaj.org/article/5a76cf5be8ef4e9aa4a2a863c7ea3745
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2
Akademický článek
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease
Autor: Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz: https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
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3
Akademický článek
Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term
Autor: Yana Vorontsova, David M. Haas, Kathleen Flannery, Andrea R. Masters, Larissa L. Silva, Rebecca C. Pierson, Brittany Yeley, Graham Hogg, David Guise, Michael Heathman, Sara K. Quinney
Publikováno v: Clinical and Translational Science, Vol 15, Iss 8, Pp 1937-1945 (2022)
Abstract The IMPROVE study (NCT02408315) compared the efficacy and safety of vaginal and buccal administration of misoprostol for full‐term, uncomplicated labor induction. This report compares the pharmacokinetics of misoprostol between vaginal and
Externí odkaz: https://doaj.org/article/7c50265f0c84462491bd4ebd26d02f28
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4
Akademický článek
Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children
Autor: Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1183-1194 (2021)
Abstract Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined. The pharmacokinetics (PKs) of methadone is highly variable due to the
Externí odkaz: https://doaj.org/article/a2dc0c6bf16a46479c6de8ed638d0c6b
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5
Akademický článek
Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study
Autor: Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi Pandey, Kelly J. Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. McCarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R. Howell, Harriet M. Williams, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Sukoff Rizzo, Paul R. Territo
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function. The anti‐seizure drug levetiracetam (LEV) is currently being evaluated in clinic
Externí odkaz: https://doaj.org/article/6aac82fc377b4d76a3023ef60872d04a
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10
Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children
Autor: Senthil Packiasabapathy, Michael A. Heathman, Senthilkumar Sadhasivam, Blessed W Aruldhas, Sara K. Quinney, Andrea R. Masters, Hongyu Gao, Brian R. Overholser, Reynold C. Ly
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1183-1194 (2021)
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined. The pharmacokinetics (PKs) of methadone is highly variable due to the variabili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a49e13543783b701bfbd16cf2ce2d2e
http://europepmc.org/articles/PMC8520746
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