Výsledky vyhledávání - "Andrea R Conlan"

Akademický článek

Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs.

Autor: Sagi Tamir, John A Zuris, Lily Agranat, Colin H Lipper, Andrea R Conlan, Dorit Michaeli, Yael Harir, Mark L Paddock, Ron Mittler, Zvi Ioav Cabantchik, Patricia A Jennings, Rachel Nechushtai

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61202 (2013)

Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfr

Externí odkaz: https://doaj.org/article/784e2a071f1348ef8f98f442fc369770

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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1

Autor: Mark L. Paddock, Ron Mittler, Rachel Nechushtai, Colin H. Lipper, Faruck Morcos, Patricia A. Jennings, Kendra L. Hailey, José N. Onuchic, Andrea R. Conlan, Assaf Friedler, Charles Wang, Chen Katz, John A. Zuris, Shahar Rotem-Bamberger, Sagi Tamir

Publikováno v: Proceedings of the National Academy of Sciences. 111:5177-5182

Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and lead to an output response. Am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b8a007c256e9dcf37b8cafca1bfee6
https://doi.org/10.1073/pnas.1403770111

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NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Autor: Vladimir Shulaev, Luhua Song, Ron Mittler, Sarah H. Holt, Abraham Hochberg, Yang Sung Sohn, Rachel Nechushtai, José N. Onuchic, Andrea R. Conlan, Dorit Michaeli, Yael Harir, Imad Matouk, Sagi Tamir, Ioav Z. Cabanchick, Patricia A. Jennings, Mark L. Paddock

Publikováno v: Proceedings of the National Academy of Sciences. 110:14676-14681

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc41401b447bc6bd14ad930b1e086e4
https://doi.org/10.1073/pnas.1313198110

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Characterization of Arabidopsis NEET Reveals an Ancient Role for NEET Proteins in Iron Metabolism

Autor: Rachel Rosen, Rachel Nechushtai, Ohad Yogev, Yael Eisenberg-Domovich, Vincent Ma, Luhua Song, Oded Livnah, Yuting Luo, Ron Mittler, Yael Harir, John A. Zuris, Patricia A. Jennings, Zvi Ioav Cabantchik, Mark L. Paddock, Andrea R. Conlan, Dorit Michaeli

Publikováno v: The Plant Cell. 24:2139-2154

The NEET family is a newly discovered group of proteins involved in a diverse array of biological processes, including autophagy, apoptosis, aging, diabetes, and reactive oxygen homeostasis. They form a novel structure, the NEET fold, in which two pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46ca0bfe571ba1fee3442e575e65c86
https://doi.org/10.1105/tpc.112.097634

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Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

Autor: Mark L. Paddock, José N. Onuchic, Sagi Tamir, Zvi Ioav Cabantchik, Andrea R. Conlan, Dorit Michaeli, Ron Mittler, John A. Zuris, Patricia A. Jennings, Maya Shvartsman, Rachel Nechushtai, Yael Harir

Publikováno v: Proceedings of the National Academy of Sciences. 108:13047-13052

MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys coordination of mNT’s [2Fe-2S] leads to cluster lability that is strongly de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560d39cd7434f1442186ce972d6a658f
https://doi.org/10.1073/pnas.1109986108

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Binding of Histidine in the (Cys)3(His)1-Coordinated [2Fe−2S] Cluster of Human mitoNEET

Autor: Stefan Stoll, Michelle M. Dicus, Patricia A. Jennings, Rachel Nechushtai, R. David Britt, Andrea R. Conlan, Mark L. Paddock

Publikováno v: Journal of the American Chemical Society. 132:2037-2049

Human mitoNEET is a homodimeric iron-sulfur protein located in the outer mitochondrial membrane with unknown function, but which is known to interact with thiazolidinedione diabetes drugs. Each monomer houses a [2Fe-2S] cluster with an unusual (Cys)(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26ccc60ce0d8842d6f4dcbf09737d83
https://doi.org/10.1021/ja909359g

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Resonance Raman Studies of the (His)(Cys)3 2Fe-2S Cluster of MitoNEET: Comparison to the (Cys)4 Mutant and Implications of the Effects of pH on the Labile Metal Center

Autor: Rachel Nechushtai, Mark L. Paddock, Andrea R. Conlan, Timothy F. Tirrell, Judy E. Kim, Eric J. Smoll, Patricia A. Jennings

Publikováno v: Biochemistry. 48:4747-4752

MitoNEET is a 2Fe-2S outer mitochondrial membrane protein that was initially identified as a target for anti-diabetic drugs. It exhibits a novel protein fold, and in contrast to other 2Fe-2S proteins such as Rieske proteins and ferredoxins, the metal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7ec1f7e1a7b2f100c500d8c7b95eb0
https://doi.org/10.1021/bi900028r

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A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties

Autor: Yael Eisenberg-Domovich, Jason T. Stofleth, Ron Mittler, Sagi Tamir, Oded Livnah, Colin H. Lipper, Patricia A. Jennings, Andrea R. Conlan, Mark L. Paddock, Rachel Nechushtai

Publikováno v: Acta crystallographica. Section D, Biological crystallography. 70(Pt 6)

NAF-1 is an important [2Fe–2S] NEET protein associated with human health and disease. A mis-splicing mutation in NAF-1 results in Wolfram Syndrome type 2, a lethal childhood disease. Upregulation of NAF-1 is found in epithelial breast cancer cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8184de731fc6d2f76820eb83250c31c6
https://pubmed.ncbi.nlm.nih.gov/24914968

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Engineering the Redox Potential over a Wide Range within a New Class of FeS Proteins

Autor: Danny A. Halim, Rachel Nechushtai, John A. Zuris, Mark L. Paddock, Patricia A. Jennings, E. C. Abresch, Andrea R. Conlan

Publikováno v: Journal of the American Chemical Society

MitoNEET is a newly discovered mitochondrial protein and a target of the TZD class of antidiabetes drugs. MitoNEET is homodimeric with each protomer binding a [2Fe-2S] center through a rare 3-Cys and 1-His coordination geometry. Both the fold and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f095011a02549a175e9fae6d25871f3c
https://doi.org/10.1021/ja103920k

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