Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Andrea R, Thurman"'
Autor:
Morgan S. Brown, Homaira Hanif, Kristen M. Little, Meredith R. Clark, Andrea R. Thurman, Lola Flomen, Gustavo F. Doncel
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background While oral pre-exposure prophylaxis (PrEP) has been shown to reduce the risk of HIV, challenges such as adhering to a daily-dosing regimen and persistence have emerged as barriers for at-risks populations in South Africa. This qua
Externí odkaz:
https://doaj.org/article/d5e31ac393df4fc6ab1482867d956379
Autor:
Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon, Anna-Barbara Moscicki, Richard M. Novak, Mickey V. Patel, Intira Sriprasert, Andrea R. Thurman, Sergey Yegorov, Nelly Rwamba Mugo, Alison C. Roxby, Elizabeth Micks, Florian Hladik, The Consortium for Assessing Immunity Across the Menstrual Cycle
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-32 (2022)
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown
Externí odkaz:
https://doaj.org/article/6aca5fc4f96043c18149881f3f0a4745
Autor:
Nelly R. Mugo, Victor Mudhune, Renee Heffron, Katherine K. Thomas, Eleanor McLellan-Lemal, Betty Njoroge, Sue Peacock, Siobhán M. O’Connor, Beatrice Nyagol, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Nina Isoherranen, David W. Erikson, Louise A. Ouattara, Nazita Yousefieh, Terry A. Jacot, Richard E. Haaland, Susan A. Morrison, Harald S. Haugen, Andrea R. Thurman, Shannon A. Allen, Jared M. Baeten, Taraz Samandari, Gustavo F. Doncel
Publikováno v:
Frontiers in Reproductive Health, Vol 5 (2023)
IntroductionGlobally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies.MethodsHealthy women ages 18–34 years, no
Externí odkaz:
https://doaj.org/article/5c0798227a72433685820cec538beb32
Autor:
Smritee Dabee, Nelly Mugo, Victor Mudhune, Eleanor McLellan-Lemal, Sue Peacock, Siobhan O’Connor, Betty Njoroge, Beatrice Nyagol, Andrea R. Thurman, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Harald S. Haugen, Melanie Gasper, Colin Feng, Shannon A. Allen, Gustavo F. Doncel, Heather B. Jaspan, Renee Heffron, Kisumu Combined Ring Study Team
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract In a phase-IIa trial, we investigated the influence of 90 days continuous-delivery tenofovir (TFV) intravaginal rings (IVRs) with/without levonorgestrel (LNG) on the genital microbiota of Kenyan women. Eligible women (n = 27; 18–34 years;
Externí odkaz:
https://doaj.org/article/68fd82a48b804787804310a51e78d2ca
Autor:
Andrea R. Thurman, Louise A. Ouattara, Nazita Yousefieh, Peter L. Anderson, Lane R. Bushman, Xi Fang, Homaira Hanif, Meredith Clark, Onkar Singh, Gustavo F. Doncel
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundNew multi-purpose prevention technology (MPT) products are needed to prevent human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV2). In this study, we evaluated a fast-dissolve insert that may be used vaginally or rectall
Externí odkaz:
https://doaj.org/article/a9cd0edaab2c403583152c032fe80051
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-4 (2022)
Abstract Vitrified, or “frozen”, donor eggs can either be fertilized and cultured for fresh transfer (group 1), or fertilized and cryopreserved for transfer in a “frozen embryo transfer” cycle (group 2). This study compared the pregnancy rate
Externí odkaz:
https://doaj.org/article/60aef3ed31334b1fadcc1021e43455fc
Autor:
Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Tina Cunningham, Susan Ju, Jill L. Schwartz, Sinead Delany-Moretlwe, Andrea R. Thurman, Gustavo F. Doncel
Publikováno v:
Translational Medicine Communications, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Background Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite measure of product adherence, protocol compliance, and semen exposure for determining vaginal
Externí odkaz:
https://doaj.org/article/829fb4703ac84b359d27d1df33dac805
Autor:
Christina Y. Lee, Ryan K. Cheu, Melissa M. Lemke, Andrew T. Gustin, Michael T. France, Benjamin Hampel, Andrea R. Thurman, Gustavo F. Doncel, Jacques Ravel, Nichole R. Klatt, Kelly B. Arnold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Bacterial vaginosis (BV) is typically caused by a shift in the vaginal microbiota from a Lactobacillus-dominant community to one colonised by strains of Gardenerella vaginalis and treatment with the antibiotic metronidazole (MNZ) often results in fai
Externí odkaz:
https://doaj.org/article/9d83bafea6184047b1ac4bc5543da3b9
Autor:
Andrea R. Thurman, Jacques Ravel, Pawel Gajer, Mark A. Marzinke, Louise A. Ouattara, Terry Jacot, M. Melissa Peet, Meredith R. Clark, Gustavo F. Doncel
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundA relationship between the vaginal microbiota and tenofovir (TFV) concentrations and activity after topical administration has been previously reported.ObjectiveCONRAD A15-138 was a randomized, placebo-controlled Phase I study aimed at char
Externí odkaz:
https://doaj.org/article/d591c8779d9548a1a3b5529774d71d09
Autor:
Andrea R. Thurman, Vivian Brache, Leila Cochon, Louise A. Ouattara, Neelima Chandra, Terry Jacot, Nazita Yousefieh, Meredith R. Clark, Melissa Peet, Homaira Hanif, Jill L. Schwartz, Susan Ju, Mark A. Marzinke, David W. Erikson, Urvi Parikh, Betsy C. Herold, Raina N. Fichorova, Elizabeth Tolley, Gustavo F. Doncel
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women. In this randomized, placebo-controlled, phase I study, women used a placebo or tenofovir (TFV) and l
Externí odkaz:
https://doaj.org/article/acce84a034c84494b2798735f3302ad2