Subphenotypes of Acute Respiratory Distress Syndrome: Advancing Towards Precision Medicine

Autor: Andrea R. Levine, Carolyn S. Calfee

Publikováno v: Tuberculosis and Respiratory Diseases, Vol 87, Iss 1, Pp 1-11 (2024)

Acute respiratory distress syndrome (ARDS) is a common cause of severe hypoxemia defined by the acute onset of bilateral non-cardiogenic pulmonary edema. The diagnosis is made by defined consensus criteria. Supportive care, including prevention of fu

Externí odkaz: https://doaj.org/article/eccd4fa33c1b446aaef377ab66395b44

SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women

Autor: Youri Lee, Gabrielle Grubbs, Sabrina C. Ramelli, Andrea R. Levine, Allison Bathula, Kapil Saharia, Madeleine Purcell, Shreya Singireddy, Colleen L. Dugan, Lindsey Kirchoff, Allison Lankford, Sarah Cipriano, Ryan A. Curto, Jocelyn Wu, Katherine Raja, Emily Kelley, Daniel Herr, Kevin M. Vannella, Supriya Ravichandran, Juanjie Tang, Anthony Harris, Mohammad Sajadi, Daniel S. Chertow, Alison Grazioli, Surender Khurana

Publikováno v: EBioMedicine, Vol 77, Iss , Pp 103940- (2022)

Summary: Background: Limited knowledge exists in post-partum women regarding durability of SARS-CoV-2 vaccine-induced antibody responses and their neutralising ability against SARS-CoV-2 variants of concern (VOC). Methods: We elucidated longitudinal

Externí odkaz: https://doaj.org/article/c92047276de246fc832d975751f88dac

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

Autor: Cameron R Wolfe, Kay M Tomashek, Thomas F Patterson, Carlos A Gomez, Vincent C Marconi, Mamta K Jain, Otto O Yang, Catharine I Paules, Guillermo M Ruiz Palacios, Robert Grossberg, Michelle S Harkins, Richard A Mularski, Nathaniel Erdmann, Uriel Sandkovsky, Eyad Almasri, Justino Regalado Pineda, Alexandra W Dretler, Diego Lopez de Castilla, Angela R Branche, Pauline K Park, Aneesh K Mehta, William R Short, Susan L F McLellan, Susan Kline, Nicole M Iovine, Hana M El Sahly, Sarah B Doernberg, Myoung-don Oh, Nikhil Huprikar, Elizabeth Hohmann, Colleen F Kelley, Mark Holodniy, Eu Suk Kim, Daniel A Sweeney, Robert W Finberg, Kevin A Grimes, Ryan C Maves, Emily R Ko, John J Engemann, Barbara S Taylor, Philip O Ponce, LuAnn Larson, Dante Paolo Melendez, Allan M Seibert, Nadine G Rouphael, Joslyn Strebe, Jesse L Clark, Kathleen G Julian, Alfredo Ponce de Leon, Anabela Cardoso, Stephanie de Bono, Robert L Atmar, Anuradha Ganesan, Jennifer L Ferreira, Michelle Green, Mat Makowski, Tyler Bonnett, Tatiana Beresnev, Varduhi Ghazaryan, Walla Dempsey, Seema U Nayak, Lori E Dodd, John H Beigel, Andre C Kalil, Lana Wahid, Emmanuel B. Walter, Akhila G. Belur, Grace Dreyer, Jan E. Patterson, Jason E. Bowling, Danielle O. Dixon, Angela Hewlett, Robert Odrobina, Jakrapun Pupaibool, Satish Mocherla, Suzana Lazarte, Meilani Cayabyab, Rezhan H. Hussein, Reshma R. Golamari, Kaleigh L. Krill, Sandra Rajme, Paul F. Riska, Barry S. Zingman, Gregory Mertz, Nestor Sosa, Paul A. Goepfert, Mezgebe Berhe, Emma Dishner, Mohamed Fayed, Kinsley Hubel, José Arturo Martinez-Orozco, Nora Bautista Felix, Sammy T. Elmor, Amer Ryan Bechnak, Youssef Saklawi, Jason W. Van Winkle, Diego F. Zea, Maryrose Laguio-Vila, Edward E. Walsh, Ann R. Falsey, Karen Carvajal, Robert C. Hyzy, Sinan Hanna, Norman Olbrich, Jessica J. Traenkner, Colleen S. Kraft, Pablo Tebas, Jillian T Baron, Corri Levine, Joy Nock, Joanne Billings, Hyun Kim, Marie-Carmelle Elie-Turenne, Jennifer A. Whitaker, Anne F. Luetkemeyer, Jay Dwyer, Emma Bainbridge, Pyoeng Gyun Choe, Chang Kyung Kang, Nikolaus Jilg, Valeria D Cantos, Divya R. Bhamidipati, Srinivasa Nithin Gopalsamy, Aarthi Chary, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Constance A. Benson, Kimberly McConnell, Jennifer P. Wang, Mireya Wessolossky, Katherine Perez, Taryn A Eubank, Catherine Berjohn, Gregory C. Utz, Patrick E.H. Jackson, Taison D. Bell, Heather M. Haughey, Abeer Moanna, Sushma Cribbs, Telisha Harrison, Christopher J. Colombo, Christina Schofield, Rhonda E. Colombo, Victor F. Tapson, Jonathan Grein, Fayyaz Sutterwala, Dilek Ince, Patricia L. Winokur, Monica Fung, Hannah Jang, David Wyles, Maria G. Frank, Ellen Sarcone, Henry Neumann, Anand Viswanathan, Sarah Hochman, Mark Mulligan, Benjamin Eckhardt, Ellie Carmody, Neera Ahuja, Kari Nadeau, David Svec, Jeffrey C. Macaraeg, Lee Morrow, Dave Quimby, Mary Bessesen, Lindsay Nicholson, Jill Adams, Princy Kumar, Allison A. Lambert, Henry Arguinchona, Radica Z. Alicic, Sho Saito, Norio Ohmagari, Ayako Mikami, David Chien Lye, Tau Hong Lee, Po Ying Chia, Lanny Hsieh, Alpesh N. Amin, Miki Watanabe, Keith A. Candiotti, Jose G. Castro, Maria A. Antor, Tida Lee, Tahaniyat Lalani, Richard M. Novak, Andrea Wendrow, Scott A. Borgetti, Sarah L. George, Daniel F. Hoft, James D. Brien, Stuart H. Cohen, George R. Thompson, Melony Chakrabarty, Faheem Guirgis, Richard T. Davey, Jocelyn Voell, Jeffrey R. Strich, David A. Lindholm, Katrin Mende, Trevor R. Wellington, Rekha R. Rapaka, Jennifer S. Husson, Andrea R. Levine, Seow Yen Tan, Humaira Shafi, Jaime M F Chien, David C. Hostler, Jordanna M. Hostler, Brian T. Shahan, David H. Adams, Anu Osinusi, Huyen Cao, Timothy H. Burgess, Julia Rozman, Kevin K. Chung, Christina Nieuwoudt, Jill A. El-Khorazaty, Heather Hill, Stephanie Pettibone, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, Gregory A. Deye, Effie Nomicos, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Tammy Yokum, Janice Arega, Ruth Florese

Publikováno v: The Lancet. Respiratory medicine, vol 10, iss 9

BackgroundBaricitinib and dexamethasone have randomised trials supporting their use for the treatment of patients with COVID-19. We assessed the combination of baricitinib plus remdesivir versus dexamethasone plus remdesivir in preventing progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bf26e0fb42cf7314743a90932e8d69
https://doi.org/10.1016/s2213-2600(22)00088-1

Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Autor: H. Nida Sen, Kevin M. Vannella, Yujuan Wang, Joon-Yong Chung, Shilpa Kodati, Sabrina C. Ramelli, Jung Wha Lee, Paola Perez, Sydney R. Stein, Alison Grazioli, James M. Dickey, Kris Ylaya, Manmeet Singh, Kwe Claude Yinda, Andrew Platt, Marcos J. Ramos-Benitez, Christa Zerbe, Vincent J. Munster, Emmie de Wit, Blake M. Warner, Daniel L. Herr, Joseph Rabin, Kapil K. Saharia, David E. Kleiner, Stephen M. Hewitt, Chi-Chao Chan, Daniel S. Chertow, Andrew P. Platt, Shelly J. Curran, Ashley L. Babyak, Luis Perez Valencia, Mary E. Richert, Willie J. Young, Sarah P. Young, Billel Gasmi, Michelly Sampaio De Melo, Sabina Desar, Saber Tadros, Nadia Nasir, Xueting Jin, Sharika Rajan, Esra Dikoglu, Neval Ozkaya, Stefania Pittaluga, Grace Smith, Elizabeth R. Emanuel, Brian Kelsall, Justin A. Olivera, Megan Blawas, Nicole Hays, Madeleine Purcell, Shreya Singireddy, Jocelyn Wu, Katherine Raja, Ryan Curto, Jean Chung, Amy Borth, Kimberly Bowers, Anne Weichold, Paula Minor, Mirahmad Moshref, Emily Kelly, Mohammad M. Sajadi, Thomas M. Scalea, Douglas Tran, Ronson J. Madathil, Siamak Dahi, Kristopher B. Deatrick, Eric M. Krause, Joseph A. Herrold, Ali Tabatabai, Eric Hochberg, Christopher Cornachione, Andrea R. Levine, Justin E. Richards, John Elder, Allen Burke, Michael A. Mazzeffi, Robert Christenson, Zackary Chancer, Mustafa Abdulmahdi, Sabrina Sopha, Tyler Goldberg, Shahabuddin Soherwardi, Yashvir Sangwan, Michael T. McCurdy, Kristen Sudano, Diane Blume, Bethany Radin, Madhat Arnouk, James W. Eagan

Publikováno v: The American Journal of Pathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0e75a98e2a0f6cf664b6a7c0cdfee8b
https://doi.org/10.1016/j.ajpath.2023.02.016

Thromboelastography Parameters do not Discriminate for Thrombotic Events in Hospitalized Patients With COVID-19

Autor: Susan, Kartiko, Naoru, Koizumi, David, Yamane, Babak, Sarani, Abu B, Siddique, Andrea R, Levine, Amanda M, Jackson, Patrick M, Wieruszewski, Nathan J, Smischney, Ashish K, Khanna, Jonathan H, Chow

Publikováno v: Journal of intensive care medicine.

Background Coronavirus disease 2019 (COVID-19) is associated with a prothrombotic state; leading to multiple sequelae. We sought to detect whether thromboelastography (TEG) parameters would be able to detect thromboembolic events in patients hospital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679881d4b7d177e7751e4f9a55c0d2a3
https://pubmed.ncbi.nlm.nih.gov/36448250