Discovery of senolytics using machine learning

Autor: Vanessa Smer-Barreto, Andrea Quintanilla, Richard J. R. Elliott, John C. Dawson, Jiugeng Sun, Víctor M. Campa, Álvaro Lorente-Macías, Asier Unciti-Broceta, Neil O. Carragher, Juan Carlos Acosta, Diego A. Oyarzún

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest in targeted elimination of senescent cells, only few se

Externí odkaz: https://doaj.org/article/e5ccd2506b57415b914f0283468b2085

p21 as a transcriptional co-repressor of S-phase and mitotic control genes.

Autor: Nuria Ferrándiz, Juan M Caraballo, Lucía García-Gutierrez, Vikram Devgan, Manuel Rodriguez-Paredes, M Carmen Lafita, Gabriel Bretones, Andrea Quintanilla, M Jose Muñoz-Alonso, Rosa Blanco, Jose C Reyes, Neus Agell, M Dolores Delgado, G Paolo Dotto, Javier León

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37759 (2012)

It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems. To investigate the roles of p21 in transcriptional control, we studied the gene expression changes in two huma

Externí odkaz: https://doaj.org/article/32600aef584b489fad30b84dc5ce7907

Discovery of new senolytics using machine learning

Autor: Vanessa Smer-Barreto, Andrea Quintanilla, Richard J. R. Elliot, John C. Dawson, Jiugeng Sun, Neil O. Carragher, Juan Carlos Acosta, Diego A. Oyarzún

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Cellular senescence is a stress response characterised by a permanent cell cycle arrest and a proinflammatory secretome. In addition to its tumour suppressor role, senescence is involved in ageing and promotes many disease processes such as cancer, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bca725b4064ef47922b94b21463e1f6
http://hdl.handle.net/10261/269843

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Autor: Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos, Juan Carlos Acosta

Publikováno v: Cell Death Differ . 2022 Jun;29(6):1267-1282
Fernández Duran, I, Quintanilla, A, Tarrats, N, Birch, J, Hari, P, Millar, F, Lagnado, A B, Smer Barreto, V, Muir, M, Brunton, V G, Passos, J F & Acosta, J-C 2021, ' Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence ', Cell Death & Differentiation (CDD) . https://doi.org/10.1038/s41418-021-00917-6

Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis. Here we show that LPS-mediated acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce177258f275c02b93ca1b905d0bff14
http://hdl.handle.net/10261/284983

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

Autor: Andrea Quintanilla, Alison M. Meynert, Margaret C. Frame, Simon Wilkinson, Priya Hari, Adam Pennycuick, Luke Boulter, Elisabeth Freyer, Wallace Wa, John C. Connelly, Sam M. Janes, Juan Carlos Acosta, Morwenna Muir, Andrew H. Sims, Philippe Gautier, Vitor H. Teixeira, Fraser R. Millar

Targeting early-stage lung cancer is vital to improve overall survival. We previously identified Toll-like receptor 2 (TLR2) as a regulator of oncogene-induced senescence (OIS) and the senescence-associated secretory phenotype (SASP), both key for tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b30039cd74356b79013c5e3a858bc0e
https://doi.org/10.1101/2021.06.04.446876