Supplementary Figure 2 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Autor: Fabiola Moretti, Alfredo Pontecorvi, Ada Sacchi, Antonio Marchetti, Silvia Soddu, Antonella Farsetti, Fiamma Buttitta, Stefano Iacovelli, Andrea Prodosmo, Carla Martella, Fabio Barassi, Lara Felicioni, Giorgia Sparaco, Francesca Gentiletti, Francesca Mancini, Simona Giglio

Supplementary Figure 2 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0c0d527c11bc7e8a92c100d0a71058
https://doi.org/10.1158/0008-5472.22367265.v1

Supplementary Figure 1 from HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA

Autor: Silvia Soddu, Galina Selivanova, Ada Sacchi, Alice Moncada, Francesca Siepi, Andrea Prodosmo, Cinzia Rinaldo

Supplementary Figure 1 from HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab0caacc7e4eb50ec87d8f2af72333e
https://doi.org/10.1158/0008-5472.22378245

Data from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Autor: Fabiola Moretti, Alfredo Pontecorvi, Ada Sacchi, Antonio Marchetti, Silvia Soddu, Antonella Farsetti, Fiamma Buttitta, Stefano Iacovelli, Andrea Prodosmo, Carla Martella, Fabio Barassi, Lara Felicioni, Giorgia Sparaco, Francesca Gentiletti, Francesca Mancini, Simona Giglio

The HDMX protein is closely related to HDM2 with which it shares different structural domains, particularly the p53 binding domain and the ring finger domain, where the two HDM proteins interact. Several oncogenic forms derived from splicing of HDM2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b55624003cb7c47fd35a797cecc21b6
https://doi.org/10.1158/0008-5472.c.6495486.v1

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

Autor: Davide Valente, Andrea Prodosmo, Luca L. Fava, Cinzia Rinaldo, Ilaria Virdia, Giuliana Di Rocco, Laura Monteonofrio, Luciana Chessa, Silvia Soddu, Antonio Musio, Claudia Contadini

Publikováno v: Cell Death and Disease, Vol 10, Iss 11, Pp 1-16 (2019)
Cell death and disease 10 (2019). doi:10.1038/s41419-019-2076-1
info:cnr-pdr/source/autori:Contadini, Claudia; Monteonofrio, Laura; Virdia, Ilaria; Prodosmo, Andrea; Valente, Davide; Chessa, Luciana; Musio, Antonio; Fava, Luca L.; Rinaldo, Cinzia; Di Rocco, Giuliana; Soddu, Silvia/titolo:p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway/doi:10.1038%2Fs41419-019-2076-1/rivista:Cell death and disease/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Cell Death & Disease

Centrosomal p53 has been described for three decades but its role is still unclear. We previously reported that, in proliferating human cells, p53 transiently moves to centrosomes at each mitosis. Such p53 mitotic centrosome localization (p53-MCL) oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2908e42b533ed749e6a2f210244afb2
http://link.springer.com/article/10.1038/s41419-019-2076-1

Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Autor: Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo, Maurizio Cosimelli, Gian Luca Grazi, Giacomo Corrado, Enrico Vizza, Giuseppe Giannini, Silvia Soddu

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR

Background Variant ATM heterozygotes have an increased risk of developing cancer, cardiovascular diseases, and diabetes. Costs and time of sequencing and ATM variant complexity make large-scale, general population screenings not cost-effective yet. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094023cc9bca1975ea0c7b9e521955c5
https://pubmed.ncbi.nlm.nih.gov/27599564