Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrea Piée‐Staffa"'
Autor:
Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Journal of Advanced Research, Vol 60, Iss , Pp 201-214 (2024)
Introduction: Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the develop
Externí odkaz:
https://doaj.org/article/0bdd50c9fd09429e928b1f2b75be1138
Autor:
Christian Marx, Jürgen Sonnemann, Mandy Beyer, Oliver D. K. Maddocks, Sergio Lilla, Irene Hauzenberger, Andrea Piée‐Staffa, Kanstantsin Siniuk, Suneetha Nunna, Lisa Marx‐Blümel, Martin Westermann, Tobias Wagner, Felix B. Meyer, René Thierbach, Christina S. Mullins, Said Kdimati, Michael Linnebacher, Francesco Neri, Thorsten Heinzel, Zhao‐Qi Wang, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3404-3429 (2021)
Late‐stage colorectal cancer (CRC) is still a clinically challenging problem. The activity of the tumor suppressor p53 is regulated via post‐translational modifications (PTMs). While the relevance of p53 C‐terminal acetylation for transcription
Externí odkaz:
https://doaj.org/article/0b74c48fb69942fab1d217753fe500f2
Autor:
Teodora Nikolova, Bernd Kaina, Kerstin Borgmann, Mengwan Wang, Nadine Piecha, Andrea Piée-Staffa, Nancy Berte
Structures of CCNU and HR inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd7ea25c69df8cabfa5b66788ba6249
https://doi.org/10.1158/1535-7163.22506594
https://doi.org/10.1158/1535-7163.22506594
Autor:
Teodora Nikolova, Bernd Kaina, Kerstin Borgmann, Mengwan Wang, Nadine Piecha, Andrea Piée-Staffa, Nancy Berte
Malignant gliomas exhibit a high level of intrinsic and acquired drug resistance and have a dismal prognosis. First- and second-line therapeutics for glioblastomas are alkylating agents, including the chloroethylating nitrosoureas (CNU) lomustine, ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fce105862f01cb99f2b33a6059b2ad7
https://doi.org/10.1158/1535-7163.c.6538440.v1
https://doi.org/10.1158/1535-7163.c.6538440.v1
Autor:
Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer
IntroductionPosttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a93a992bfae64cae79dafac24079711
https://doi.org/10.1101/2023.03.09.531973
https://doi.org/10.1101/2023.03.09.531973
Autor:
Nicole Kiweler, Helena Schwarz, Alexandra Nguyen, Stephanie Matschos, Christina Mullins, Andrea Piée-Staffa, Christina Brachetti, Wynand P. Roos, Günter Schneider, Michael Linnebacher, Walburgis Brenner, Oliver H. Krämer
Publikováno v:
Cell Biology and Toxicology.
The epigenetic modifier histone deacetylase-2 (HDAC2) is frequently dysregulated in colon cancer cells. Microsatellite instability (MSI), an unfaithful replication of DNA at nucleotide repeats, occurs in about 15% of human colon tumors. MSI promotes
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7006 (2020)
Methadone is an analgesic drug used for pain treatment and heroin substitution. Recently, methadone has been proposed to be useful also for cancer therapy, including glioblastoma multiforme (GBM), the most severe form of brain cancer, because experim
Externí odkaz:
https://doaj.org/article/9a40387b61b14ccfa4f12636c4374211