Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrea Paula-Lima"'
Autor:
Pedro Lobos Zambrano, Ignacio Vega, Barbara Bruna, Silvia Gleitze, Jorge Toledo, Steffen Hartel, Maria Hidalgo, Andrea Paula-Lima
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S440- (2023)
Externí odkaz:
https://doaj.org/article/8599ff390a234b5cad6c77a2dcdcfffb
Autor:
Pedro Lobos, Ignacio Vega-Vásquez, Barbara Bruna, Silvia Gleitze, Jorge Toledo, Steffen Härtel, Cecilia Hidalgo, Andrea Paula-Lima
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1972 (2023)
Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive function
Externí odkaz:
https://doaj.org/article/88a0ccc9eab9414d995c1efde9f9eb0d
Autor:
Iván Plaza-Rosales, Enzo Brunetti, Rodrigo Montefusco-Siegmund, Samuel Madariaga, Rodrigo Hafelin, Daniela P. Ponce, María Isabel Behrens, Pedro E. Maldonado, Andrea Paula-Lima
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments of AD. Howev
Externí odkaz:
https://doaj.org/article/413fae253960466b9a1d32b7c102ef7b
Autor:
Silvia Gleitze, Omar A. Ramírez, Ignacio Vega-Vásquez, Jing Yan, Pedro Lobos, Hilmar Bading, Marco T. Núñez, Andrea Paula-Lima, Cecilia Hidalgo
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 705 (2023)
Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione perox
Externí odkaz:
https://doaj.org/article/7e44a1aca8de4abd84363887a9a07e2c
Autor:
Jaime Díaz-Zúñiga, Jamileth More, Samanta Melgar-Rodríguez, Matías Jiménez-Unión, Francisca Villalobos-Orchard, Constanza Muñoz-Manríquez, Gustavo Monasterio, José Luis Valdés, Rolando Vernal, Andrea Paula-Lima
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Periodontal disease is a disease of tooth-supporting tissues. It is a chronic disease with inflammatory nature and infectious etiology produced by a dysbiotic subgingival microbiota that colonizes the gingivodental sulcus. Among several periodontal b
Externí odkaz:
https://doaj.org/article/dfb9e78ca92d4dddb46250d91723729f
Autor:
Jamileth More, Nadia Galusso, Pablo Veloso, Luis Montecinos, José Pablo Finkelstein, Gina Sanchez, Ricardo Bull, José Luis Valdés, Cecilia Hidalgo, Andrea Paula-Lima
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
We have previously reported that primary hippocampal neurons exposed to synaptotoxic amyloid beta oligomers (AβOs), which are likely causative agents of Alzheimer’s disease (AD), exhibit abnormal Ca2+ signals, mitochondrial dysfunction and defecti
Externí odkaz:
https://doaj.org/article/1882cddefc984ef3822c2a8eb2f6c849
Autor:
Francisca García, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farías, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima, Álvaro O. Ardiles, Cecilia Hidalgo, Tatiana Adasme, Pablo Muñoz
Publikováno v:
Marine Drugs, Vol 18, Iss 6, p 335 (2020)
Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen specie
Externí odkaz:
https://doaj.org/article/c5063f1f59fd4d28ae07eeb71284f2cf
Autor:
Pedro Lobos, Barbara Bruna, Alex Cordova, Pablo Barattini, Jose Luis Galáz, Tatiana Adasme, Cecilia Hidalgo, Pablo Muñoz, Andrea Paula-Lima
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer’s disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce aberrant Ca2+ signals at sublethal concentrati
Externí odkaz:
https://doaj.org/article/afac18c5045a4f49b04c3054e031acb0
Autor:
Ignacio Vega-Vásquez, Pedro Lobos, Jorge Toledo, Tatiana Adasme, Andrea Paula-Lima, Cecilia Hidalgo
Publikováno v:
Biochemical and biophysical research communications. 633
The hippocampus is a brain region implicated in synaptic plasticity and memory formation; both processes require neuronal Ca
Autor:
Pablo Bolaños-Villegas, Franco Cabrerizo, Federico Brown, Patricia Zancan, John F. Barrera, Pablo A. González-Muñoz, Hernán Grecco, Alexis Kalergis, Andrea Paula-Lima, Ronald Vargas-Balda, Rolando Gittens, Sandra López Vergès, Christian Wilson
Latin America is home to more than 600 million people and has considerable natural and human resources. However, investment in science and technology (S&T) lags far behind that in developed countries. This gap represents a barrier to the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a4dff4472b1b417ab68cf86cb062e7
https://doi.org/10.14293/s2199-1006.1.sor-.ppbpkuj.v2
https://doi.org/10.14293/s2199-1006.1.sor-.ppbpkuj.v2