Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrea Panella"'
Autor:
Giovanni Ventura, Maria Incoronata Nardella, Andrea Panella, Fabio Arnesano, Cosima Damiana Calvano, Ilario Losito, Francesco Palmisano, Tommaso R. I. Cataldi
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12914-12922 (2018)
Externí odkaz:
https://doaj.org/article/09098e4dd79645b7bd9443803cb811bd
Autor:
Fabio Arnesano, Giovanni Ventura, Maria Incoronata Nardella, Ilario Losito, Francesco Palmisano, Tommaso R. I. Cataldi, Cosima Damiana Calvano, Andrea Panella
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12914-12922 (2018)
Pt(II)-based derivatives bearing a cyanocobalamin (CNCbl) unit were synthesized in aqueous solutions, and the reaction mixtures were examined by reversed-phase liquid chromatography with electrospray ionization and linear ion trap mass spectrometry (
Autor:
Gino Cingolani, Maria Grazia Perrone, Antonio Scilimati, Paola Vitale, Roger S. Armen, Giuseppe Di Mauro, Savina Ferorelli, William L. Smith, Cosimo G. Fortuna, Andrea Panella
Publikováno v:
European Journal of Medicinal Chemistry. 138:661-668
The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding to two diarylisoxazoles: mofezolac, which is polar and ionizable, and
Publikováno v:
Medicinal Research Reviews. 36:641-671
Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2. AA is in turn released from the cell membrane upon neopathological stimuli. COX inhibitors interfere in this catalytic an
Publikováno v:
Fluorinated Pharmaceuticals: Advances in Medicinal Chemistry. :126-139
Autor:
Andrea Panella, Savina Ferorelli, Paola Vitale, Maria Grazia Perrone, Marialessandra Contino, Antonio Scilimati, Antonio Lavecchia
A new set of cyclooxygenase (COX) inhibitors endowed with an additional functionality was explored. These new compounds also contained either rhodamine 6G or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, two moieties typical of efflux pump substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef6c49238dc1d36933471704bbcd3f2
http://hdl.handle.net/11588/634865
http://hdl.handle.net/11588/634865
Publikováno v:
Medicinal research reviews. 36(4)
Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2. AA is in turn released from the cell membrane upon neopathological stimuli. COX inhibitors interfere in this catalytic an
A novel set of 1,4-diaryl-1,2,3-triazoles were projected as a tool to study the effect of both the heteroaromatic triazole as a core ring and a variety of chemical groups with different electronic features, size and shape on the catalytic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1422edb643b01d6294eb5cbbc82f119
http://hdl.handle.net/20.500.11769/35380
http://hdl.handle.net/20.500.11769/35380
Autor:
Antonio Scilimati, Francesco De Nuccio, Maria Antonietta Panaro, Maria Grazia Perrone, Dario Domenico Lofrumento, Antonia Cianciulli, Velia La Pesa, Paola Vitale, Rosa Calvello, Andrea Panella
Publikováno v:
Pharmacology. 95(1-2)
Background/Aims: Gastrointestinal damage (GD) is commonly associated with the inhibition of cyclooxygenase (COX)-1, one of the two known COXs, by traditional non-steroidal anti-inflammatory drugs. More recent evidences have proven that GD is caused b
Autor:
Jashim Uddin, Antonio Scilimati, Paola Malerba, Mike Nickels, Brenda C. Crews, H. Charles Manning, Maria Grazia Perrone, Mohammed N. Tantawy, Cristina K. Daniel, Paola Vitale, Kebreab Ghebreselasie, Andrea Panella, Lawrence J. Marnett
Cyclooxygenase-1 (COX-1), but not COX-2, is expressed at high levels in the early stages of human epithelial ovarian cancer where it seems to play a key role in cancer onset and progression. As a consequence, COX-1 is an ideal biomarker for early ova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71507cc267be52fad949c103ba13df23
https://europepmc.org/articles/PMC4401082/
https://europepmc.org/articles/PMC4401082/