Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Andrea Pagnani"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Adeno-associated viruses 2 (AAV2) are minute viruses renowned for their capacity to infect human cells and akin organisms. They have recently emerged as prominent candidates in the field of gene therapy, primarily attributed to their inheren
Externí odkaz:
https://doaj.org/article/553499d5eb064011adeae295355f32b3
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011812 (2024)
The design of proteins with specific tasks is a major challenge in molecular biology with important diagnostic and therapeutic applications. High-throughput screening methods have been developed to systematically evaluate protein activity, but only a
Externí odkaz:
https://doaj.org/article/748fac7a95b3481d9d0044122031bc14
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Boltzmann machines are energy-based models that have been shown to provide an accurate statistical description of domains of evolutionary-related protein and RNA families. They are parametrized in terms of local biases accounting
Externí odkaz:
https://doaj.org/article/79f58c0ef7fa43cbb4914ca48a168964
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Deep learning is a powerful tool for the design of novel protein sequences, yet can be computationally very inefficient. Here the authors propose using simple forecasting models to efficiently generate a large number of novel protein structures.
Externí odkaz:
https://doaj.org/article/26264fe401544f27b9d9bdba0ab20a68
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/2eaf24d098cd45e59b558cf99db29fe5
Autor:
Irene Franco, Anna Johansson, Karl Olsson, Peter Vrtačnik, Pär Lundin, Hafdis T. Helgadottir, Malin Larsson, Gwladys Revêchon, Carla Bosia, Andrea Pagnani, Paolo Provero, Thomas Gustafsson, Helene Fischer, Maria Eriksson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aging skeletal muscle shows declining numbers and activity of satellite cells. Here, Franco et al. show that in satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched i
Externí odkaz:
https://doaj.org/article/0363043147a94b90adfd4993239327c0
Autor:
Bahareh Behkamal, Mahmoud Naghibzadeh, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh, Andrea Pagnani, Kamal Al Nasr
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1773 (2021)
Cryo-electron microscopy (cryo-EM) is a structural technique that has played a significant role in protein structure determination in recent years. Compared to the traditional methods of X-ray crystallography and NMR spectroscopy, cryo-EM is capable
Externí odkaz:
https://doaj.org/article/236bbdc7b1d74afe83d9315b96869af0
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract The inverse problem is studied in multi-body systems with nonlinear dynamics representing, e.g., phase-locked wave systems, standard multimode and random lasers. Using a general model for four-body interacting complex-valued variables we tes
Externí odkaz:
https://doaj.org/article/d276f0427c344c6c85a98c57d390224b
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Large-scale metabolic models of organisms from microbes to mammals can provide great insight into cellular function, but their analysis remains challenging. Here, the authors provide an approximate analytic method to estimate the feasible solution sp
Externí odkaz:
https://doaj.org/article/a310c3829c1b4c4c9dfde675741de891
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006767 (2019)
It is well known that, in order to preserve its structure and function, a protein cannot change its sequence at random, but only by mutations occurring preferentially at specific locations. We here investigate quantitatively the amount of variability
Externí odkaz:
https://doaj.org/article/6d7d70e742734e51af10aaa23ef3e660