Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrea Olland"'
The eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 11076-11086 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 11076-11086 (2021)
To further elucidate the mechanism of action and binding properties of eptinezumab to calcitonin gene-related peptide (CGRP), X-ray crystallography, computational alanine scanning, and molecular dynamics were used. X-ray diffraction data were collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d1cc402c5c42c2f412f6bee06148d1
https://doi.org/10.1080/21655979.2021.2006977
https://doi.org/10.1080/21655979.2021.2006977
Autor:
Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Andrzej Ardzinski, Kristi Yi Fan, Emily P. Thi, Bruce D. Dorsey, Kim Stever, Tim Chiu, Sunny Tang, Owen Daly, Janet R. Phelps, Troy Harasym, Andrea Olland, Robert K. Suto, Michael J. Sofia
Publikováno v:
RSC Med Chem
Disruption of the HBV viral life cycle with small molecules that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clinically validated approach to inhibiting HBV viral replication. Herein we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d746e0df2833c3377ff3c4df6151d
https://europepmc.org/articles/PMC8942244/
https://europepmc.org/articles/PMC8942244/
Autor:
Van Phung, Higbee Jared Martin, Marilyn Wang, Rowena Suriben, Yan Wang, Dina A. Ayupova, Diana Li, Hung-I Harry Chen, Subhash D. Katewa, André O. White, Zhengyu Gao, Michele McEntee, Andrea Olland, Damodharan Lakshminarasimhan, Richard Ventura, Michael Chen, Julie Oeffinger, Jie Tang, Shelley R. Starck, Jer-Yuan Hsu, Darrin A. Lindhout, Pranali Taskar, Kalyani Mondal, Mark J. Solloway, Raj Haldankar, Avantika Kekatpure, Bernard B. Allan, Betty Chan Li
Publikováno v:
Nature medicine. 26(8)
Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival1. Tumor-induced perturbations in the endocrine, immune and nervous systems drive anorexia and catabolic changes in adipose tissue and skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6269b35aef81f42e7c7d2627e1afde
https://pubmed.ncbi.nlm.nih.gov/32877689
https://pubmed.ncbi.nlm.nih.gov/32877689
Autor:
Stacia Kargman, Andrew John Jennings, Michael Miller, Andrew Stamford, Damodharan Lakshminarasimhan, Lewis C. Cantley, Anita D. Robin, Mayako Michino, David J. Huggins, Jiayi Xu, Edouard Mullarky, Andrea Olland, Daisuke Tomita, Naoyoshi Noguchi, Guoan Zhang, Peter T. Meinke, Taojunfeng Su
Publikováno v:
Bioorg Med Chem Lett
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there has been considerable interest in developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f16e67aacdf7a18e54b2d994c08873d
https://pubmed.ncbi.nlm.nih.gov/31327531
https://pubmed.ncbi.nlm.nih.gov/31327531
Autor:
William S. Somers, Daniel King, Adarsh Godbole, Lidia Mosyak, Oleg V. Kovalenko, Valerie Calabro, Lioudmila Tchistiakova, Caroline J. Barelle, Nicole Piche-Nicholas, Kristine Svenson, Mischa R. Müller, Davinder Gill, Andrea Olland
Publikováno v:
Journal of Biological Chemistry. 288:17408-17419
The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain variable regions (V-NARs). Following shark immunization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2596d880914164cba81e6d7b83aa4a3c
https://doi.org/10.1074/jbc.m112.435289
https://doi.org/10.1074/jbc.m112.435289
Autor:
Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in binding as well as cell-proliferation ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292118865b349b233211d45dbcb33006
https://doi.org/10.1016/j.bmcl.2011.05.102
https://doi.org/10.1016/j.bmcl.2011.05.102
Autor:
Steve Jacobsen, Peter H. Reinhart, Albert J. Robichaud, William Ronald Solvibile, Michael S. Malamas, Jim Turner, Koi Michele Morris, Andrea Olland, Ping Zhou, Kristi Fan, Jim Erdei, Menelas N. Pangalos, David Riddell, Dominick Anthony Quagliato, Erik Wagner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6597-6605
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17719aeaede49b88c03aa1d414605290
https://doi.org/10.1016/j.bmcl.2010.09.029
https://doi.org/10.1016/j.bmcl.2010.09.029
Autor:
Xin Han, Charles Ingalls, Russell Dushin, Middleton Brawner Floyd, Thomas Nittoli, Katherine Cheung, Yongbo Hu, K T Arndt, G. Grosu, Bing Guo, Heidi L. Fraser, Allan Wissner, Andrea Olland
Publikováno v:
European Journal of Medicinal Chemistry. 45:1379-1386
A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent and relatively selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a386fbdfbe585a340f415a4ed8d9f4f
https://doi.org/10.1016/j.ejmech.2009.12.036
https://doi.org/10.1016/j.ejmech.2009.12.036
Autor:
Jonathan A. Bard, Michael S. Malamas, Kristi Fan, Andrea Olland, Albert J. Robichaud, Erik Wagner, Yun Hu, Yu Hui, Iwan Gunawan, Jim Turner, Matthew R. Johnson, Jim Erdei, Keith D. Barnes
Publikováno v:
Journal of Medicinal Chemistry. 52:6314-6323
The identification of small molecule aminoimidazoles as potent and selective human beta-secretase inhibitors is reported. These analogues demonstrate low nannomolar potency for BACE1 in a FRET assay, exhibit comparable activity in a cell-based (ELISA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aded807991850e84a3d1ebc0b011df4
https://doi.org/10.1021/jm9006752
https://doi.org/10.1021/jm9006752
Autor:
Kerry Kelleher, Ron Kriz, Mark Stahl, Lidia Mosyak, Mark Johnson, Laura Lin, Shenping Liu, Andrea Olland, Yohann R. Misquitta
Phosphorylation of inhibitor of nuclear transcription factor κB (IκB) by IκB kinase (IKK) triggers the degradation of IκB and migration of cytoplasmic κB to the nucleus where it promotes the transcription of its target genes. Activation of IKK i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf6da697ad5a037454253e53f3abbfd
https://europepmc.org/articles/PMC3829360/
https://europepmc.org/articles/PMC3829360/