Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrea Oeckinghaus"'
Autor:
Zoltán Pethő, Karolina Najder, Stephanie Beel, Benedikt Fels, Ilka Neumann, Sandra Schimmelpfennig, Sarah Sargin, Maria Wolters, Klavs Grantins, Eva Wardelmann, Miso Mitkovski, Andrea Oeckinghaus, Albrecht Schwab
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression triggers pancreatic stellate cells (PSCs)
Externí odkaz:
https://doaj.org/article/917ef2c5c0ad45b0bfab8102214a7f29
Autor:
Sílvio Terra Stefanello, Caren Rigon Mizdal, Ihab Azzam, Lilly Döhlinger, Andrea Oeckinghaus, Victor Shahin
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 9, Pp n/a-n/a (2022)
Lung cancer is the leading cause of cancer deaths. Nonsmall cell lung cancer (NSCLC) accounts for the vast majority of the histological subtypes and at advanced stage exhibits extremely low survival rate. Certain compounds, such as glycols, inhibit m
Externí odkaz:
https://doaj.org/article/6bca76d1634f4a17aa200aab2c0a9ca8
Autor:
Stephanie Beel, Lina Kolloch, Lisa H. Apken, Lara Jürgens, Andrea Bolle, Nadine Sudhof, Sankar Ghosh, Eva Wardelmann, Michael Meisterernst, Konrad Steinestel, Andrea Oeckinghaus
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression throu
Externí odkaz:
https://doaj.org/article/e878ae5e8abb4a2ba7984f050a3bbfcc
Autor:
Sílvio Terra Stefanello, Isabelle Luchtefeld, Ivan Liashkovich, Zoltan Pethö, Ihab Azzam, Etmar Bulk, Gonzalo Rosso, Lilly Döhlinger, Bettina Hesse, Andrea Oeckinghaus, Victor Shahin
Publikováno v:
Advanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
Abstract Nuclear pore complexes (NPCs) selectively mediate all nucleocytoplasmic transport and engage in fundamental cell‐physiological processes. It is hypothesized that NPCs are critical for malignant transformation and survival of lung cancer ce
Externí odkaz:
https://doaj.org/article/64ba9750775a4c848ffe9a2230db63df
Autor:
Isabel Meininger, Richard A. Griesbach, Desheng Hu, Torben Gehring, Thomas Seeholzer, Arianna Bertossi, Jan Kranich, Andrea Oeckinghaus, Andrea C. Eitelhuber, Ute Greczmiel, Andreas Gewies, Marc Schmidt-Supprian, Jürgen Ruland, Thomas Brocker, Vigo Heissmeyer, Florian Heyd, Daniel Krappmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction d
Externí odkaz:
https://doaj.org/article/b82a72dd5f0a44099bcaaa35fbf30349
Autor:
Andrea Oeckinghaus, Thomas S. Postler, Ping Rao, Heike Schmitt, Verena Schmitt, Yenkel Grinberg-Bleyer, Lars I. Kühn, Christian W. Gruber, Gustav E. Lienhard, Sankar Ghosh
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1793-1807 (2014)
The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell dea
Externí odkaz:
https://doaj.org/article/5b67b8598de34034a20b0e582f77b51e
Autor:
Katharina Fitzian, Claudia Antoni, Stephanie Beel, Anna Livia Linard Matos, Andrea Oeckinghaus, Sabine Wilhelm, Laura Brohée, Volker Gerke, Daniel Kümmel, Constantinos Demetriades, Stephan Kiontke, Reinhard Zech, Christian Ungermann, Mark Nellist, Anne Brückner, Stefan Raunser, Raphael Gasper
Publikováno v:
Mol Cell
Molecular cell 81(13), 2705-2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
Molecular Cell, 81(13), 2705-2721.e8. Cell Press
Molecular cell 81(13), 2705-2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
Molecular Cell, 81(13), 2705-2721.e8. Cell Press
Molecular cell 81(13), 2705 - 2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase activa
The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fb22ee6c6cdbeb33964f3d482b883a
https://hdl.handle.net/21.11116/0000-000A-B789-D
https://hdl.handle.net/21.11116/0000-000A-B789-D
Autor:
Lisa H, Apken, Andrea, Oeckinghaus
Publikováno v:
International review of cell and molecular biology. 361
The RAL proteins RALA and RALB belong to the superfamily of small RAS-like GTPases (guanosine triphosphatases). RAL GTPases function as molecular switches in cells by cycling through GDP- and GTP-bound states, a process which is regulated by several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c80094b8c357442e0ee348325f569d61
https://pubmed.ncbi.nlm.nih.gov/34074494
https://pubmed.ncbi.nlm.nih.gov/34074494
Autor:
Andrea Oeckinghaus, Lisa H. Apken
Publikováno v:
Signal Transduction in Cancer and Immunity ISBN: 9780128237571
The RAL proteins RALA and RALB belong to the superfamily of small RAS-like GTPases (guanosine triphosphatases). RAL GTPases function as molecular switches in cells by cycling through GDP- and GTP-bound states, a process which is regulated by several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f0711fc9ef19bb142b8b4cdadc1a98
https://doi.org/10.1016/bs.ircmb.2020.10.005
https://doi.org/10.1016/bs.ircmb.2020.10.005
Autor:
Lisa H. Apken, Andrea Bolle, Lara Jürgens, Stephanie Beel, Konrad Steinestel, Lina Kolloch, Nadine Sudhof, Michael Meisterernst, Sankar Ghosh, Andrea Oeckinghaus, Eva Wardelmann
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model of KRasG12D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c16063203f89f82bc09bb1d35b205