Výsledky vyhledávání

Akademický článek

Interaction of age and mechanical stability on bone defect healing: an early transcriptional analysis of fracture hematoma in rat.

Autor: Andrea Ode, Georg N Duda, Sven Geissler, Stephan Pauly, Jan-Erik Ode, Carsten Perka, Patrick Strube

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106462 (2014)

Among other stressors, age and mechanical constraints significantly influence regeneration cascades in bone healing. Here, our aim was to identify genes and, through their functional annotation, related biological processes that are influenced by an

Externí odkaz: https://doaj.org/article/27ad8233f65140aeb2d00ae00ac9e004

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Akademický článek

Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.

Autor: Markus Wagegg, Timo Gaber, Ferenz L Lohanatha, Martin Hahne, Cindy Strehl, Monique Fangradt, Cam Loan Tran, Kerstin Schönbeck, Paula Hoff, Andrea Ode, Carsten Perka, Georg N Duda, Frank Buttgereit

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46483 (2012)

BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (h

Externí odkaz: https://doaj.org/article/ab33291a819d4ec3917dd21aee2f13d3

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Akademický článek

Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells.

Autor: Sven Geissler, Martin Textor, Jirko Kühnisch, Delia Könnig, Oliver Klein, Andrea Ode, Tilman Pfitzner, James Adjaye, Grit Kasper, Georg N Duda

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52700 (2012)

Mesenchymal stromal cells (MSCs) are of high relevance for the regeneration of mesenchymal tissues such as bone and cartilage. The promising role of MSCs in cell-based therapies and tissue engineering appears to be limited due to a decline of their r

Externí odkaz: https://doaj.org/article/810687435b4f4c69b71ff6d5f0825a61

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CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells

Autor: Paula Kolar, Georg N. Duda, Andreas Kurtz, Petra Schrade, Dietmar W. Hutmacher, Andrea Ode, Frank Buttgereit, Kai Lehmann, Katharina Schmidt-Bleek, Jessica Kopf, Grit Kasper

Publikováno v: European Cells & Materials, Vol 22, Pp 26-42 (2011)
Scopus-Elsevier

The assumption that mesenchymal stromal cell (MSC)based-therapies are capable of augmenting physiological regeneration processes has fostered intensive basic and clinical research activities. However, to achieve sustained therapeutic success in vivo,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd887e3e40fb4ccaf1750c819ecad99
https://doi.org/10.22203/ecm.v022a03

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Modulation of Matrix Metalloprotease-2 Levels by Mechanical Loading of Three-Dimensional Mesenchymal Stem Cell Constructs: Impact onIn VitroTube Formation

Autor: Grit Kasper, Petra Knaus, Juliane D. Glaeser, Andrea Ode, Christian J. Schipp, Georg Matziolis, Sven Geissler, Carsten Perka, William R. Taylor, Georg N. Duda

Publikováno v: Tissue Engineering Part A. 16:3139-3148

Angiogenesis is essential to tissue reconstitution, is sensitive to mechanical stresses, and currently represents one of the major challenges in tissue engineering. The pro-angiogenic matrix metalloprotease-2 (MMP-2) is upregulated in mechanically lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bec0bccd51258dfc8d9e4867eb286a6
https://doi.org/10.1089/ten.tea.2009.0508

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Toward biomimetic materials in bone regeneration: Functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components

Autor: Georg Matziolis, Georg N. Duda, Simone Frauenschuh, Andrea Ode, Carsten Perka, Juliane D. Glaeser, Cameron J. Wilson, Grit Kasper

Publikováno v: Journal of Biomedical Materials Research-Part A

Bone defect treatments can be augmented by mesenchymal stem cell (MSC) based therapies. MSC interaction with the extracellular matrix (ECM) of the surrounding tissue regulates their functional behavior. Understanding of these specific regulatory mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b1fd0c31e4db196800146fe82f7ded
https://doi.org/10.1002/jbm.a.32909

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Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity

Autor: Grit Kasper, Anne Baerenwaldt, Manav Mehta, Patrick Strube, Andrea Ode, Jessica Trippens, Cameron J. Wilson, Carsten Perka, Georg N. Duda

Publikováno v: Bone

Introduction The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc8972989f51b8429a153fbac479cd6
https://doi.org/10.1016/j.bone.2009.08.005

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Matrix Metalloprotease Activity Is an Essential Link Between Mechanical Stimulus and Mesenchymal Stem Cell Behavior

Autor: Grit Kasper, Andrea Ode, Georg Matziolis, Juliane D. Glaeser, Jens Tuischer, Sven Geissler, Carsten Perka, Georg N. Duda

Publikováno v: Stem Cells. 25:1985-1994

Progenitor cells are involved in the regeneration of the musculoskeletal system, which is known to be influenced by mechanical boundary conditions. Furthermore, matrix metalloproteases (MMPs) and tissue-specific inhibitors of metalloproteases (TIMPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ebe8c938adce209f1e3e7e05db01b6
https://doi.org/10.1634/stemcells.2006-0676

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Amino-polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles are Suitable for Monitoring of Human Mesenchymal Stromal Cells In Vivo

Autor: Peter Guttmann, Frank Schulze, Paul Zaslansky, Anke Dienelt, Lindsey A. Crowe, Georg N. Duda, Janosch Schoon, Jean-Paul Vallée, Azza Gramoun, Heinrich Hofmann, Sven Geissler, Lionel Maurizi, Andrea Ode, Katja Henzler

Publikováno v: Small, Vol. 10, No 21 (2014) pp. 4340-4351
Small
Small, Wiley-VCH Verlag, 2014, pp.n/a-n/a. ⟨10.1002/smll.201400707⟩

Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell-therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs' bio-distribution in vivo using s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57a26d9d1feff30a6ce774a6263b685
https://doi.org/10.1002/smll.201400707

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Impact of heart failure on the behavior of human neonatal stem cells in vitro

Autor: K. Klose, Kyung-Sun Kang, Andreas Kurtz, Yeong-Hoon Choi, Rajika Roy, Karen Bieback, A Brodarac, Andrea Ode, Christof Stamm

Publikováno v: Journal of Translational Medicine

Background Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function. Juvenile cells possibly represent a more potent alternative, but the impact of patient-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a524916602c444ad98cb0bff58ad5a30
https://doi.org/10.1186/1479-5876-11-236

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