Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Andrea Nuzzi"'
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An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freunds Adjuvant Rat Model of Arthritis
Autor: Fabiola Bonezzi, Oscar Sasso, Silvia Pontis, Natalia Realini, Fabio Bertozzi, Daniele Piomelli, Stefano Ponzano, Andrea Nuzzi, Annalisa Fiasella, Elisa Romeo
Publikováno v: Bonezzi, FT; Sasso, O; Pontis, S; Realini, N; Romeo, E; Ponzano, S; et al.(2016). An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 356(3), 656-663. doi: 10.1124/jpet.115.230516. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9f1335w5
The endogenous lipid amides, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), exert marked antinociceptive and anti-inflammatory effects in animal models by engaging nuclear peroxisome proliferator-activated receptor-α. PEA and OEA are prod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74873a3af9c373b4f663ee47e81d99f8
https://doi.org/10.1124/jpet.115.230516
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3
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation
Autor: Valeria Capurro, Luisa Mengatto, Giorgio Tarzia, Andrea Armirotti, Angelo Reggiani, Guillermo Moreno-Sanz, Silvia Pontis, Elisa Romeo, Valerio Chiurchiù, Fabio Bertozzi, Daniele Piomelli, Alison Ribeiro, Mauro Maccarrone, Tiziano Bandiera, Marco Mor, Andrea Nuzzi, Annalisa Fiasella
Publikováno v: Ribeiro, A; Pontis, S; Mengatto, L; Armirotti, A; Chiurchiù, V; Capurro, V; et al.(2015). A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS Chemical Biology, 10(8), 1838-1846. doi: 10.1021/acschembio.5b00114. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/53h085tr
© 2015 American Chemical Society. Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type-α peroxisome proliferator-activated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913f73b6edb2544f3458c01848a66c04
https://doi.org/10.1021/acschembio.5b00114
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4
3-Aminoazetidin-2-one Derivatives asN-Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration
Autor: Fabio Bertozzi, Daniele Piomelli, Andrea Armirotti, Tiziano Bandiera, Giorgio Tarzia, Marco Mor, Maria Summa, Glauco Tarozzo, Annalisa Fiasella, Andrea Nuzzi
Publikováno v: ChemMedChem. 9:1602-1614
N-Acylethanolamine acid amidase (NAAA) is a cysteine hydrolase that catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide (PEA). PEA has been shown to exert anti-inflammatory and antinociceptive effects in animals by en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711220b59b98c83fb3072e981ff5a4b1
https://doi.org/10.1002/cmdc.201300546
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5
La difficile transizione verso la concorrenza nei servizi infrastrutturali: analisi empirica, identificazione delle criticitŕ e proposte di policy
Autor: Andrea Nuzzi
Publikováno v: ECONOMIA PUBBLICA. :109-143
La difficile transizione verso la concorrenza nei servizi infrastrutturali: analisi empirica, identificazione delle criticita e proposte di policy - The paper analyzes the fixed telephony and the energy (electricity and gas) services. In the first pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3239de60f99d0774589170a7fc54815a
https://doi.org/10.3280/ep2008-003005
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7
General Synthesis of C-Glycosyl Amino Acids via Proline-Catalyzed Direct Electrophilic α-Amination of C-Glycosylalkyl Aldehydes
Autor: Alessandro Massi, Alessandro Dondoni, Andrea Nuzzi
Publikováno v: Organic Letters. 10:4485-4488
Non-natural axially and equatorially linked C-glycosyl alpha-amino acids (glycines, alanines, and CH2-serine isosteres) with either S or R alpha-configuration were prepared by D- and L-proline-catalyzed (de95%) alpha-amination of C-glycosylalkyl alde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71ace79f399e4575a42415628fd762a
https://doi.org/10.1021/ol801685x
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8
A Serendipitous Discovery of a New C-Furanosyl Glycine Synthesis via Thiazole-Based Aminohomologation of Hexopyranoses
Autor: Andrea Nuzzi, Alessandro Massi, Alessandro Dondoni
Publikováno v: Synlett. 2007:0303-0307
Ring closure via microwave-assisted intramolecular OMs displacement by a γ-OBn group (O-nucleophilic attack) in protected polyhydroxylated N-Boc-thiazolylalkyl amines afforded C-furanosides (37-81%) featuring a chiral thiazolylmethylamino side chain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a63e924f421524fd6859614413b709
https://doi.org/10.1055/s-2007-967993
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9
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies
Autor: Stefano Ponzano, Giuliana Ottonello, Glauco Tarozzo, Daniele Piomelli, Sine Mandrup Bertozzi, Jose Antonio Ortega, Andrea Nuzzi, Tiziano Bandiera, Fabio Bertozzi, Chiara Pagliuca, Daniela Pizzirani, Annalisa Fiasella, Angelo Reggiani
Publikováno v: European journal of medicinal chemistry. 111
4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate (3b) is a potent, selective and systemically active inhibitor of intracellular NAAA activity, which produces profound anti-inflammatory effects in animal models. In the present work, we describe s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d7d843227c855208d5311f3e17611
https://pubmed.ncbi.nlm.nih.gov/26866968
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10
Structural analysis of human KDM5B guides histone demethylase inhibitor development
Autor: Carina Gileadi, E S Hookway, Claire Strain-Damerell, Paul Brennan, Andrea Nuzzi, Volker Badock, Radosław P. Nowak, Rab K. Prinjha, Nicholas A. Athanasou, Holger Steuber, N.A. Burgess-Brown, Jack A. Brown, A. Szykowska, Na Wu, Catrine Johansson, Sue Westaway, Martin Philpott, Shonagh Munro, S. Velupillai, Jola Kopec, Udo Oppermann, Ursula Egner, Nicholas B LaThangue, Anthony Tumber
Publikováno v: Nature chemical biology. 12(7)
Members of the KDM5 (also known as JARID1) family are 2-oxoglutarate- and Fe(2+)-dependent oxygenases that act as histone H3K4 demethylases, thereby regulating cell proliferation and stem cell self-renewal and differentiation. Here we report crystal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576057925b41e7c64ed6b66c5fbcd452
https://pubmed.ncbi.nlm.nih.gov/27214403
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