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Autor:
A. David Rodrigues, Louis Leung, Hugh A. Barton, Michael D. Aleo, Yvonne Will, Sarah Lazzaro, R. Scott Obach, Chester Costales, Scott W Allen, Falgun Shah, Andrea Nilson
Publikováno v:
Chemical research in toxicology. 33(1)
The hepatic risk matrix (HRM) was developed and used to differentiate lead clinical and back-up drug candidates against competitor/marketed drugs within the same pharmaceutical class for their potential to cause human drug-induced liver injury (DILI)