Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andrea N. Flynn"'
Autor:
Cara L. Sherwood, Marina N. Asiedu, Zhenyu Zhang, Josef Vagner, Dipti V. Tillu, Theodore J. Price, Scott Boitano, Candy M. Rivas, Justin Hoffman, Andrea N. Flynn, Kathryn DeFea
Publikováno v:
British Journal of Pharmacology. 172:4535-4545
Background and Purpose Proteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resu
Publikováno v:
Pain. 156:923-930
More than half of all cancer patients will suffer significant pain during the course of their disease. The strategic localization of TMPRSS2, a membrane-bound serine protease, on the cancer cell surface may allow it to mediate signal transduction bet
Autor:
Andrea N. Flynn, Dipti V. Tillu, Marina N. Asiedu, Theodore J. Price, Renata Patek, Justin Hoffman, Zhenyu Zhang, Scott Boitano, Josef Vagner, Cara L. Sherwood
Publikováno v:
The FASEB Journal. 27:1498-1510
Protease-activated receptor-2 (PAR2) is a G-protein coupled receptor (GPCR) associated with a variety of pathologies. However, the therapeutic potential of PAR2 is limited by a lack of potent and specific ligands. Following proteolytic cleavage, PAR2
Autor:
Stephanie M. Schulz, Justin Hoffman, Cara L. Sherwood, Irina Gruzinova, Michael O. Daines, Scott Boitano, Andrea N. Flynn
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L605-L614
Allergens are diverse proteins from mammals, birds, arthropods, plants, and fungi. Allergens associated with asthma (asthmagens) share a common protease activity that may directly impact respiratory epithelial biology and lead to symptoms of asthma.
Autor:
Andrea N. Flynn, Theodore J. Price, Stephanie M. Schulz, Justin Hoffman, Josef Vagner, Scott Boitano
Publikováno v:
Journal of Medicinal Chemistry. 54:1308-1313
Novel peptidomimetic pharmacophores to PAR(2) were designed based on the known activating peptide SLIGRL-NH(2). A set of 15 analogues was evaluated with a model cell line (16HBE14o-) that highly expresses PAR(2). Cells exposed to the PAR(2) activatin
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3591-3596
Electrolyte transport through and between airway epithelial cells controls the quantity and composition of the overlying liquid. Many studies have shown acute regulation of transcellular ion transport in airway epithelia. However, whether ion transpo
Autor:
Scott Boitano, Cara L. Sherwood, Andrea N. Flynn, Marina N. Asiedu, Josef Vagner, Justin Hoffman, Theodore J. Price, Zhenyu Zhang, Kathryn DeFea
Publikováno v:
The FASEB Journal. 28
Protease-activated receptor-2 (PAR2) is a GPCR activated by proteolytic cleavage of the extracellular NH2-terminus resulting in a newly exposed peptide sequence or “tethered ligand.” Potent and efficacious peptidomimetic agonists have been develo
Autor:
Brian L. Schmidt, Andrea N. Flynn
Publikováno v:
The FASEB Journal. 27
Autor:
Justin Hoffman, Josef Vagner, Zhenyu Zhang, Cara L. Sherwood, Scott Boitano, Andrea N. Flynn, Theodore J. Price, Renata Patek, Dipti V. Tillu
Publikováno v:
Web of Science
Autor:
Theodore J. Price, Andrea N. Flynn, Scott Boitano, Renata Patek, Dipti V. Tillu, Josef Vagner, Justin Hoffman, Zhenyu Zhang
Publikováno v:
Bioconjugate chemistry. 23(10)
Protease activated receptor-2 (PAR(2)) is one of four G-protein coupled receptors (GPCRs) that can be activated by exogenous or endogenous proteases, which cleave the extracellular amino-terminus to expose a tethered ligand and subsequent G-protein s