Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Andrea N, Edginton"'
Autor:
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 576-588 (2024)
Abstract Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this
Externí odkaz:
https://doaj.org/article/7ff55455941a418ca3f7d873a040d3c9
Autor:
Samuel D.J. Dubinsky, PharmD, Kevin M. Watt, MD, PhD, Carina E. Imburgia, BSc, Autumn M. Mcknite, BSc, J. Porter Hunt, PhD, Cassandra Rice, PhD, Joseph E. Rower, PhD, DABCP, Andrea N. Edginton, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 12, p e1010 (2023)
OBJECTIVES:. Patients with sepsis are at significant risk for multiple organ dysfunction, including the lungs and kidneys. To manage the morbidity associated with kidney impairment, continuous renal replacement therapy (CRRT) may be required. The ext
Externí odkaz:
https://doaj.org/article/594b1e7149d64ebb8c4dc94f0d2a2b8c
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 320-332 (2023)
Abstract Cannabidiol (CBD) is approved for treatment of seizures associated with two forms of epilepsy that become apparent in infancy or early childhood. To consider an adult physiologically‐based pharmacokinetic (PBPK) model for pediatric scaling
Externí odkaz:
https://doaj.org/article/5c080e5b866245dbabe47413166f9d7b
Autor:
Cindy Hoi Ting Yeung, Sherilyn K. D. Houle, Philip O. Anderson, Brookie M. Best, Samuel Dubinsky, Andrea N. Edginton
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionBreastfeeding has major benefits to the maternal-infant dyad and yet healthcare providers have expressed uncertainty about advocating breastfeeding when mothers are taking medications. The tendency for some providers to be more cautious i
Externí odkaz:
https://doaj.org/article/55e66c1ed5064b06be3c08a7ac818841
Autor:
Jacqueline G. Gerhart, Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, Andrew M. Atz, Amira Al‐Uzri, Paula Delmore, Daniel Gonzalez, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 778-791 (2022)
Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is cr
Externí odkaz:
https://doaj.org/article/dd4ab2e51fa44b86a239b72f4ea91718
Autor:
Olav Versloot, Emma Iserman, Pierre Chelle, Federico Germini, Andrea N. Edginton, Roger E. G. Schutgens, Alfonso Iorio, Kathelijn Fischer, on behalf of the prophylaxis working group of the International Prophylaxis Study Group
Publikováno v:
HemaSphere, Vol 6, Iss 4, p e694 (2022)
Predicting individual effects of switching from standard half-life (SHL) to extended half-life (EHL) FVIII/FIX concentrates is pivotal in clinical care, but large-scale individual data are scarce. The aim of this study was to assess individual change
Externí odkaz:
https://doaj.org/article/f626da3065fe4222aeef113e825b9188
Autor:
Jacqueline G. Gerhart, Stephen Balevic, Jaydeep Sinha, Eliana M. Perrin, Jian Wang, Andrea N. Edginton, Daniel Gonzalez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Childhood obesity is an alarming public health problem. The pediatric obesity rate has quadrupled in the past 30 years, and currently nearly 20% of United States children and 9% of children worldwide are classified as obese. Drug distribution and eli
Externí odkaz:
https://doaj.org/article/7a90c9cc0656433783c0cb0ed53e8d77
Autor:
Paul R. V. Malik, Andrea N. Edginton
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 835-844 (2019)
The comparative performances of physiologically‐based pharmacokinetic (PBPK) modeling and allometric scaling for predicting the pharmacokinetics (PKs) of large molecules in pediatrics are unknown. Therefore, both methods were evaluated for accuracy
Externí odkaz:
https://doaj.org/article/733adba46bb64ddd9391d74713afd12f
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 3, Pp 528-541 (2019)
Abstract The objective of this scoping review is to summarize the current use of pharmacokinetics for tailoring prophylaxis in hemophilia patients switching between clotting factor products. Patients with hemophilia may require switching of clotting
Externí odkaz:
https://doaj.org/article/e3a9a731c69f4de6b6edffe681edbcd1
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 172 (2022)
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-depe
Externí odkaz:
https://doaj.org/article/43f9305030f642b5a258a94cf602c45c