Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrea MacFadden"'
Autor:
Erik W. Hartwick, David A. Costantino, Andrea MacFadden, Jay C. Nix, Siqi Tian, Rhiju Das, Jeffrey S. Kieft
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Complex RNA three-dimensional structures undergo functionally important programmed conformational changes. Here, the authors report how two structurally and functionally coupled RNA domains within a viral 3′-UTR sense the ribosome through conformat
Externí odkaz:
https://doaj.org/article/9e3575109598441c9bf349e416a47825
Autor:
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally
Externí odkaz:
https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e0764
Publikováno v:
RNA. 29:847-861
Ligation by plant and fungal RNA ligases yields an internal 2′-phosphate group on each RNA ligation product. In budding yeast, this covalent mark occurs at the splice junction of two targets of ligation: intron-containing tRNAs and the messenger RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b6866fcef3d6bad8f94ead8e648a42
https://doi.org/10.1261/rna.079290.122
https://doi.org/10.1261/rna.079290.122
Publikováno v:
Science
Viruses require multifunctional structured RNAs to hijack their host’s biochemistry, but their mechanisms can be obscured by the difficulty of solving conformationally dynamic RNA structures. Using cryo–electron microscopy (cryo-EM), we visualize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a0e85ba3ac257157e0d2debe7ae3e1
https://doi.org/10.1126/science.abe8526
https://doi.org/10.1126/science.abe8526
Ligation by plant and fungal RNA ligases yields an internal 2′-phosphate group on each RNA ligation product. In budding yeast, this covalent mark occurs at the splice junction of two targets of ligation: intron-containing tRNAs and the messenger RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50659868756f71ef6fab14d2c1747e44
https://doi.org/10.1101/2022.05.29.493267
https://doi.org/10.1101/2022.05.29.493267
Publikováno v:
RNA
Viruses commonly use specifically folded RNA elements that interact with both host and viral proteins to perform functions important for diverse viral processes. Examples are found at the 3′ termini of certain positive-sense ssRNA virus genomes whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634770548865189f0255873ae3d896eb
https://doi.org/10.1261/rna.076968.120
https://doi.org/10.1261/rna.076968.120
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a137-a137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::286109f63a1079945e2b76b776d02c58
https://doi.org/10.1107/s205327332209862x
https://doi.org/10.1107/s205327332209862x
Publikováno v:
RNA (New York, N.Y.). 27(6)
Structured RNA elements are common in the genomes of RNA viruses, often playing critical roles during viral infection. Some RNA elements use forms of tRNA mimicry, but the diverse ways this mimicry can be achieved are poorly understood. Histidine-acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867c42dcbf1f9eff90174df8e5f734e1
https://pubmed.ncbi.nlm.nih.gov/33811147
https://pubmed.ncbi.nlm.nih.gov/33811147
Viruses require multifunctional structured RNAs to hijack their host’s biochemistry, but their mechanisms can be obscured by the difficulty of solving conformationally dynamic RNA structures. Using cryo-EM, we visualized the structure of the myster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed5af7147d17c79487f05f4c10b4ee3
https://doi.org/10.1101/2020.09.18.302638
https://doi.org/10.1101/2020.09.18.302638
Structured RNA elements that protect RNA transcripts from 5’→3’ degradation are becoming useful research tools. Here we show that exonuclease-resistant RNA structures (xrRNAs) from Flaviviruses can be used to protect heterologous messenger RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0379cf73517df040bef5bb81496798f
https://doi.org/10.1101/2020.06.25.169177
https://doi.org/10.1101/2020.06.25.169177