Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Andrea M. Sefler"'
Publikováno v:
Magnetic Resonance in Chemistry. 55:224-232
Two-dimensional (2D) data are typically truncated in both dimensions, but invariably and severely so in the indirect dimension. These truncated FIDs and/or interferograms are extensively zero filled, and Fourier transformation of such zero-filled dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec411fdb7c0ae545bfb15c2416bd1760
https://doi.org/10.1002/mrc.4449
https://doi.org/10.1002/mrc.4449
Publikováno v:
Magnetic resonance in chemistry : MRC. 55(3)
Two-dimensional (2D) data are typically truncated in both dimensions, but invariably and severely so in the indirect dimension. These truncated FIDs and/or interferograms are extensively zero filled, and Fourier transformation of such zero-filled dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8875ff773e837eef6c8fc3c7b8280932
https://pubmed.ncbi.nlm.nih.gov/27160956
https://pubmed.ncbi.nlm.nih.gov/27160956
Autor:
Lee Moss, Cosette J. Serabjit-Singh, Andrea M. Sefler, J. Sigafoos, Mark de Serres, Stephen Castellino, Gary D Bowers
Publikováno v:
Xenobiotica. 40:437-445
GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity against HIV/AIDS efavirenz- and nevirapine-resistant viruses. In mice, rats, and monkeys following oral administration of [(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01a8e957a82d7f8b9707c9d1ae8ca6
https://doi.org/10.3109/00498251003770578
https://doi.org/10.3109/00498251003770578
Autor:
Andrea M. Sefler, Timothy D. Spitzer, Edgar R. Wood, O. Bradley McDonald, Bryan R. Reep, Eric E. Boros, James B. Thompson
Publikováno v:
Journal of Heterocyclic Chemistry. 41:355-358
5-Methoxy and 5-anilinopyrido[2,3-d]pyrimidin-7(8H)-ones 2a-2f were obtained by a tandem Michael addition-cyclization reaction of methanol and anilines with pyrimidinylpropynoate 5. Methoxy derivative 2a was obtained in 62% yield by treatment of 5 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2678f8ce6bf7b778ba81cf5560bdc26e
https://doi.org/10.1002/jhet.5570410308
https://doi.org/10.1002/jhet.5570410308
Autor:
Timothy M. Willson, John T. Moore, Robert L. Johnson, Roderick G. Davis, Andrea M. Sefler, Barry G. Shearer, Alan D. Thornquest, Ann B. Miller, Tim Spitzer, Aaron B. Miller, G. Bruce Wisely, Shawn P. Williams
Publikováno v:
Structure. 10(9):1225-1234
The 2.7 A X-ray crystal structure of the HNF4gamma ligand binding domain (LBD) revealed the presence of a fatty acid within the pocket, with the AF2 helix in a conformation characteristic of a transcriptionally active nuclear receptor. GC/MS and NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08723d422b07d390ceb635c5db3ad88f
Publikováno v:
Magnetic Resonance in Chemistry. 39:539-543
Two new pulse sequences are presented for the acquisition of DEPT–HMQC spectra, based on the original experiment of Kessler et al. The new sequences employ modifications intended to make the experiment well suited for high-throughput acquisition an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a1f83fbd2972224f519f5093a4641d
https://doi.org/10.1002/mrc.883
https://doi.org/10.1002/mrc.883
Autor:
Samuel W. Gerritz, Andrea M. Sefler
Publikováno v:
Journal of Combinatorial Chemistry. 2:127-133
Solid-phase MAS techniques have proved to be very useful in characterizing compounds bound to resin; however, little has been reported on using NMR to characterize compounds attached to Chiron SynPhase crowns. We have used proton, carbon, and COSY sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804bb44f24d661cf75499a16ed6a0fd2
https://doi.org/10.1021/cc9900551
https://doi.org/10.1021/cc9900551
Publikováno v:
Journal of the American Chemical Society. 120:4105-4112
The macrocyclic arrays of heterocycles and amides present in Lissoclinum peptides can serve as templates for selective metal ion binding and as lead structures for the design of conformationally preorganized peptides and peptidomimetics. The currentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839e536f15d25c361098cd5a9630f258
https://doi.org/10.1021/ja973580h
https://doi.org/10.1021/ja973580h
Autor:
Andrea M. Sefler, Kelli D. Plunket, Nicholas C. O. Tomkinson, Timothy M. Willson, Steven G. Blanchard, Derek J. Parks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2491-2496
A library of thiazolidinedione-fatty acid hybrid molecules was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c71cc0ee21962a4eda31a95fe5433470
https://doi.org/10.1016/s0960-894x(97)10017-8
https://doi.org/10.1016/s0960-894x(97)10017-8
Autor:
David E. Wemmer, Andrea M. Sefler, Paul A. Bartlett, Rachael A. Maplestone, Ho S. Cho, Witold N. Hruzewicz, Kim Liu, Corey W. Liu, Richard E. Austin
Publikováno v:
Journal of the American Chemical Society. 119:6461-6472
The bicyclic diacid 1 was designed as a semi-rigid template for the hydrogen-bonding pattern of a peptide α-helix. The protected precursor 7 was synthesized in eight steps from tert-butyl 3,5-dimet...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c953842365e08f4dbb64beac7c711f
https://doi.org/10.1021/ja964231a
https://doi.org/10.1021/ja964231a