Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andrea M. Lockie"'
Autor:
Karen James, Ian Collins, Kathy Boxall, Brian Dymock, Paul Workman, Florence I. Raynaud, Chrisostomos Prodromou, Angela Hayes, Suzanne A. Eccles, Kwai-Ming J. Cheung, Allan E. Surgenor, Paul Webb, Martin J. Drysdale, D. Lee Walmsley, Stuart C. Ray, Allan M. Jordan, Jenifer Borgognoni, Vanessa Martins, Swee Y. Sharp, Andrea M. Lockie, Nicholas G. M. Davies, R. Howes, Lisa Wright, Thomas P. Matthews, Andrew Massey, Michael Wood, Roderick E. Hubbard, Wynne Aherne, Stephen D. Roughley, Alexandra Fink, Harry Finch, Julie E. Cansfield, Christopher J. Northfield, Paul Brough, Edward McDonald, Xavier Barril, Laurence H. Pearl
Publikováno v:
Journal of Medicinal Chemistry. 51:196-218
Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, synthesis, structure-activity relationships and pharmacokinetics of potent sma
Publikováno v:
Rapid Communications in Mass Spectrometry. 16:433-441
A simple method for the derivatization of primary amines and carboxylic acids with tris(trimethoxyphenyl)phosphonium (TMPP) reagents to enhance their detection by electrospray mass spectrometry (ESI-MS) has been developed. The synthesis of novel TMPP
Autor:
Sarah Denny, Andrew Cansfield, Philip Stephen Jackson, Jonathan D. Moore, Douglas S. Williamson, Peter Kierstan, Lan-Zhen Wang, Simon F. Scrace, Joanne Wayne, Andrea M. Lockie, Nicola J. Curtin, Carol Bentley, David R. Newell, Jenifer Borgognoni
Publikováno v:
Cell cycle (Georgetown, Tex.). 7(24)
Transient treatment with small molecule CDK inhibitors is toxic to cancer cells and leads to depletion of anti-apoptotic proteins and Chk1, coupled with DNA damage and induction of apoptosis. Here we have examined, which of these phenomena are necess
Autor:
Alan Robertson, Justin Bower, Andrew Cansfield, Pawel Dokurno, James B. Murray, Jonathan D. Moore, Jenifer Powles, Geraint L. Francis, Richard Hebdon, Martin J. Parratt, Andrea M. Lockie, Douglas S. Williamson, Philip Stephen Jackson, Allan E. Surgenor, Christopher J. Torrance, Claire L. Nunns, Christine M. Richardson, Rob Howes
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(4)
The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for C