Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

Autor: Nurit P. Azouz, Andrea M. Klingler, Mark Rochman, Misu Paul, Julie M. Caldwell, Michael Brusilovsky, Alexander T. Dwyer, Xiaoting Chen, Daniel Miller, Arthur Lynch, Carmy Forney, Leah C. Kottyan, Matthew T. Weirauch, Marc E. Rothenberg

Eosinophilic esophagitis (EoE) is a type 2 allergic disease characterized by esophageal inflammation and epithelial cell dysfunction. Acquired loss of the anti-serine protease of kazal type 7 (SPINK7) in the squamous epithelium of the esophagus has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f0b71c007d0a0f3391cfb22d5bf4b83
https://doi.org/10.1101/2023.05.17.541192

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Autor: Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer

Publikováno v: bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America

Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

Autor: Tim Hempel, Lluís Raich, Simon Olsson, Nurit P. Azouz, Andrea M. Klingler, Marc E. Rothenberg, Frank Noé

The entry of the coronavirus SARS-CoV-2 into human cells can be inhibited by the approved drugs camostat and nafamostat. Here we elucidate the molecular mechanism of these drugs by combining experiments and simulations.In vitroassays confirm the hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cd35257e180469e0b23fd20f21d76b0
https://doi.org/10.1101/2020.07.21.214098

Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors

Autor: Mark Rochman, Marc E. Rothenberg, Andrea M. Klingler, Julie M. Caldwell, Nurit P. Azouz, Yong Mei Xie, Lydia E Mack, Garrett A. Osswald

Publikováno v: J Allergy Clin Immunol

Background Proton pump inhibitors (PPIs) have been recognized as a primary treatment of eosinophilic esophagitis (EoE), an allergic inflammatory disease of the esophageal mucosa. The mechanisms underlying esophageal epithelial responses to PPIs remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23d8854e29a0de576b700542f89da09
https://pubmed.ncbi.nlm.nih.gov/33289661

Characterization of a Mouse Model of Hypereosinophilic Syndrome

Autor: Daniel R. Prows, Shelli M. Homan, Nives Zimmermann, William Gibbons, Andrea M. Klingler

Publikováno v: Blood. 132:3686-3686

Introduction: Hypereosinophilic syndrome is characterized by sustained blood and/or tissue hypereosinophilia leading to tissue damage and organ dysfunction. Nearly half the cases are classified as idiopathic, since no known cause is identified and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e01533e6de474a1df8acefdd1ddbc8c
https://doi.org/10.1182/blood-2018-99-113909