Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrea M. Holderbaum"'
Autor:
Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of spe
Externí odkaz:
https://doaj.org/article/a16f75dc242345688e57e18ad40b740a
Autor:
Jason E. Galloway, Andrea M. Holderbaum, Namrata Arya, Suohui Zhang, Michael S. Bodnar, Ruthann Norman, William E. Carson, Lianbo Yu, Kari L. Kendra, Christin E. Burd
Publikováno v:
Aging and Cancer, Vol 1, Iss 1-4, Pp 58-70 (2020)
Abstract Background The impact of biologic aging on immune checkpoint inhibitor (ICI) toxicity and efficacy is underexplored in metastatic melanoma (MM). In peripheral blood T lymphocytes (PBTLs), biologic aging is characterized by changes in T‐cel
Externí odkaz:
https://doaj.org/article/2c40ae84ca684e13a38c61652404594d
Autor:
Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Externí odkaz:
https://doaj.org/article/22d587f58b184e8ba68ff0e088f3e21b
Autor:
Lianbo Yu, Michael S Bodnar, William E. Carson, Ruthann Norman, Kari Kendra, Andrea M. Holderbaum, Christin E. Burd, Namrata Arya, Suohui Zhang, Jason E. Galloway
Publikováno v:
Aging Cancer
Aging and Cancer, Vol 1, Iss 1-4, Pp 58-70 (2020)
Aging and Cancer, Vol 1, Iss 1-4, Pp 58-70 (2020)
Background The impact of biologic aging on immune checkpoint inhibitor (ICI) toxicity and efficacy is underexplored in metastatic melanoma (MM). In peripheral blood T lymphocytes (PBTLs), biologic aging is characterized by changes in T‐cell composi
Autor:
Keziah Daniels, Vladimir Ustiyan, James M. Wells, Debora Sinner, Stephen L. Trisno, Jessica L. Kinney, John M. Shannon, Vladimir V. Kalinichenko, Kunal Agarwal, Andrea M. Holderbaum, Praneet Chaturvedi, Talia Nasr, Aaron M. Zorn
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are
Autor:
Michael S Bodnar, Tirzah J Weiss, Min Chen, Craig J. Burd, Vincenzo Coppola, Andrea M. Holderbaum, Marie Fort, Christin E. Burd, Brandon M. Murphy, Aastha Dhakal
Distinct NRAS mutants are enriched in various tumor types. Here, we generated a suite of fully congenic, conditional, Nras knock-in mouse models (LSL-Nras Q61R, -K, -L, -H, -P, -Q; G12D and G13D, -R) to test the hypothesis that melanocyte transformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89966cd9c0b92ed576aeed123a7b5fa2
https://doi.org/10.1101/2021.01.15.426808
https://doi.org/10.1101/2021.01.15.426808
Autor:
Kathleen L. Tober, Anamaria Bonilla, Jonathan H. Zippin, James E. Gillahan, Tatiana M. Oberyszyn, Christin E. Burd, Conor Delaney, Rebecca C. Hennessey, Andrea M. Holderbaum
Publikováno v:
Pigment Cell & Melanoma Research. 30:477-487
Summary To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (UV)-induced
Autor:
Lianbo Yu, Kari Kendra, William E. Carson, Christin E. Burd, Andrea M. Holderbaum, Janice K. Kiecolt-Glaser, Suohui Zhang
Publikováno v:
Journal of Clinical Oncology. 36:e21578-e21578
e21578Background: Senescence is an irreversible cell cycle arrest associated with sustained p16INK4a (p16) expression and biological aging. The inability of senescent cells to proliferate suggests ...
Autor:
Conor Delaney, Rebecca C. Hennessey, Xing Tang, James E. Gillahan, Andrea M. Holderbaum, Raleigh D. Kladney, Christin E. Burd
Publikováno v:
Cancer Research. 76:2685-2685
Of the four molecular subtypes of melanoma (BRAF, NRAS, NF1, and triple WT), NRAS mutant tumors are notoriously more aggressive and challenging to treat. The frequent occurrence of NRAS mutations in benign, congenital nevi suggests that these genetic
Autor:
Conor Delaney, Rebecca C. Hennessey, Andrea M. Holderbaum, Raleigh D. Kladney, Kathleen L. Tober, James E. Gillahan, Tatiana M. Oberyszyn, Anamaria Bonilla, Christin E. Burd
Publikováno v:
Cancer Research. 76:900-900
Cutaneous melanoma claims the life of one American every hour, and while the etiology of this tumor type is not entirely understood, exposure to ultraviolet (UV) radiation (280-340nm) is a major risk factor. For this reason, the use of UV-blocking su