Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrea M Keane-Myers"'
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115066 (2014)
Burkholderia mallei and Burkholderia pseudomallei are potentially lethal pathogens categorized as biothreat agents due, in part, to their ability to be disseminated via aerosol. There are no protective vaccines against these pathogens and treatment o
Externí odkaz:
https://doaj.org/article/f5cbafc346f2467890b1cd32be4fdfb5
Autor:
Matthew G. Bell, Andrea M. Keane-Myers, Margaret A. Elberson, Eric M. Bachelder, Christian A. Darko, Kevin L. Schully, Kristy M. Ainslie, Barbara E. Wyslouzil, John R. Palmer, Matthew D. Gallovic
Publikováno v:
Advanced Healthcare Materials. 5:2617-2627
Subunit formulations are regarded as the safest type of vaccine, but they often contain a protein-based antigen that can result in significant challenges, such as preserving antigenicity during formulation and administration. Many studies have demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389c2b7e69cfdfcc92c0460e2ee6129d
https://doi.org/10.1002/adhm.201600642
https://doi.org/10.1002/adhm.201600642
Autor:
Matthew G. Bell, Sadhana Sharma, Kristy M. Ainslie, Andrea M. Keane-Myers, M.A. Elberson, Eric M. Bachelder, Kevin L. Schully, John T. Pesce, Kevin J. Peine, Shalini Gautam, Angela M. Prouty, Matthew D. Gallovic
Publikováno v:
International Journal of Pharmaceutics. 495:849-861
Melioidosis, a potentially lethal disease of humans and animals, is caused by the soil-dwelling bacterium Burkholderia pseudomallei. Due to B. pseudomallei's classification as a Tier 1 Select Agent, there is substantial interest in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ef6212cd44d88a4e9fe6e6d5327155
https://doi.org/10.1016/j.ijpharm.2015.09.059
https://doi.org/10.1016/j.ijpharm.2015.09.059
Autor:
Kenneth G. Frey, John T. Pesce, J Enrique Herrera-Galeano, Regina Z. Cer, Vishwesh P. Mokashi, Kevin L. Schully, Truong Luu, Kimberly A. Bishop-Lilly, Andrea M. Keane-Myers
Publikováno v:
International Journal of Genomics, Vol 2017 (2017)
International Journal of Genomics
International Journal of Genomics
Increasing evidence that microRNAs (miRNAs) play important roles in the immune response against infectious agents suggests that miRNA might be exploitable as signatures of exposure to specific infectious agents. In order to identify potential early m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec79b047a65e18e915c8cabe58a3f41
Autor:
John T. Pesce, Drew Hannaman, Matthew G. Bell, Brian D. Livingston, Andrea M. Keane-Myers, Mark T. Albrecht
Publikováno v:
Vaccine. 30:4872-4883
Electroporation of DNA vaccines represents a platform technology well positioned for the development of multivalent biodefense vaccines. To evaluate this hypothesis, three vaccine constructs were produced using codon-optimized genes encoding Bacillus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c0b01819ef1b4d47891179d6f37cf
https://doi.org/10.1016/j.vaccine.2012.04.078
https://doi.org/10.1016/j.vaccine.2012.04.078
Autor:
Andrea M. Keane-Myers, Tristan T. Beaudette, Mark T. Albrecht, Kyle E. Broaders, Alfred J. Mateczun, Jean M. J. Fréchet, Eric M. Bachelder, Kristy M. Ainslie, John T. Pesce
Publikováno v:
Molecular Pharmaceutics. 7:826-835
Toll-like receptor (TLR) agonists induce potent innate immune responses and can be used in the development of novel vaccine adjuvants. However, access to TLRs can be challenging as exemplified by TLR 7, which is located intracellularly in endosomal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d323b877b05efbf7165b745101f461
https://doi.org/10.1021/mp900311x
https://doi.org/10.1021/mp900311x
Autor:
Andrei P. Pomerantsev, Inka Sastalla, Andrea M. Keane-Myers, Olga M. Pomerantseva, Lauren M. Maltese, Stephen H. Leppla
Publikováno v:
Microbiology
Many genes in Bacillus cereus and Bacillus thuringiensis are under the control of the transcriptional regulator PlcR and its regulatory peptide, PapR. In Bacillus anthracis, the causative agent of anthrax, PlcR is inactivated by truncation, and conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a350dbc595176666ccffc794f0e9170
http://europepmc.org/articles/PMC3068694
http://europepmc.org/articles/PMC3068694
Publikováno v:
Pathogens and Disease.
In the past decade, several Bacillus cereus strains have been isolated from otherwise healthy individuals who succumbed to bacterial pneumonia presenting symptoms resembling inhalational anthrax. One strain was indistinguishable from B. cereus G9241,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9e024c7a1930e75d805ab977a49970
https://doi.org/10.1111/2049-632x.12204
https://doi.org/10.1111/2049-632x.12204
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1121
Effective multi-agent/multivalent vaccines that confer protection against more than one disease are highly desirable to the patient and to health-care professionals. Electroporation of DNA vaccines, whereby tissues injected with DNA are subjected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0af5ce88e765c0c705e5ab8c0d52e466
https://pubmed.ncbi.nlm.nih.gov/24510836
https://pubmed.ncbi.nlm.nih.gov/24510836
Autor:
Andrea M, Keane-Myers, Matt, Bell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1121
Vaccines have evolved for hundreds of years, but all utilize the premise that safely pre-exposing the host to some component of a pathogen allows for enhanced immune recognition, and potential protection from disease, upon encountering the pathogen a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9f106491b3f2020a4f2ea471ddbabda
https://pubmed.ncbi.nlm.nih.gov/24510831
https://pubmed.ncbi.nlm.nih.gov/24510831