Výsledky vyhledávání - "Andrea Luraghi"

Akademický článek

Selective SERCA2a activator as a candidate for chronic heart failure therapy

Autor: Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza, Marcella Rocchetti

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Abstract Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. Istaroxime is a dr

Externí odkaz: https://doaj.org/article/782d6a7de41e442dbf9d2b9799220397

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Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity

Autor: Nicole Gotri, Fabio A. Facchini, Alberto Minotti, Guanbo Wang, Grisha Pirianov, Marco De Andrea, Miguel A. Valvano, Alessio Romerio, Francesco Peri, Rebecca J. Ingram, Alejandra Matamoros-Recio, Charys Palmer, Sonsoles Martín-Santamaría, Andrea Luraghi, Andrea Iannucci

Publikováno v: Facchini, F A, Minotti, A, Luraghi, A, Romerio, A, Gotri, N, Matamoros-Recio, A, Iannucci, A, Palmer, C, Wang, G, Ingram, R, Martin-Santamaria, S, Pirianov, G, De Andrea, M, Valvano, M A & Peri, F 2021, ' Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity ', Journal of Medicinal Chemistry . https://doi.org/10.1021/acs.jmedchem.1c00896
Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
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Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by well-defined ligands to boost innate and adaptive immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9364a5f656e810721694dde803ba5b09
https://doi.org/10.1021/acs.jmedchem.1c00896

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Electrospinning for drug delivery applications: A review

Autor: Francesco Peri, Lorenzo Moroni, Andrea Luraghi

Publikováno v: Journal of Controlled Release. 334:463-484

Drug delivery devices are promising tools in the pharmaceutical field, as they are able to maximize the therapeutic effects of the delivered drug while minimizing the undesired side effects. In the past years, electrospun nanofibers attracted rising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4954d60a1e2e15cdbc434255dbebfc6
https://doi.org/10.1016/j.jconrel.2021.03.033

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Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure

Autor: Andrea Luraghi, Mara Ferrandi, Paolo Barassi, Martina Arici, Shih-Che Hsu, Eleonora Torre, Carlotta Ronchi, Alessio Romerio, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Antonio Zaza, Marcella Rocchetti, Francesco Peri

Publikováno v: Journal of medicinal chemistry. 65(10)

The stimulation of sarcoplasmic reticulum calcium ATPase SERCA2a emerged as a novel therapeutic strategy to efficiently improve overall cardiac function in heart failure (HF) with reduced arrhythmogenic risk. Istaroxime is a clinical-phase IIb compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed507f2f866247e4e50751e703741bc8
https://pubmed.ncbi.nlm.nih.gov/35580334

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Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis

Autor: Francesca Granucci, Ivan Monteleone, Francesco Peri, Simona Barresi, Alberto Minotti, Giovanni Monteleone, Andrea Luraghi, Davide Di Fusco, Fabio A. Facchini

Publikováno v: European Journal of Clinical Pharmacology. 76:409-418

Purpose: The partial ineffectiveness and side effects of inflammatory bowel disease (IBD) current therapies drive basic research to look for new therapeutic target in order to develop new drug lead. Considering the pivotal role played by toll-like re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb1e1628a8e95991588fa9541a4397e
https://doi.org/10.1007/s00228-019-02799-7

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A Highly Sensitive Luminescent Biosensor for the Microvolumetric Detection of the Pseudomonas aeruginosa Siderophore Pyochelin

Autor: Francesca Ungaro, Raffaella Sorrentino, Mattia Pirolo, Daniela Visaggio, Emma Mitidieri, Andrea Luraghi, Massimiliano Lucidi, Paolo Visca, Francesco Peri, Emanuela Frangipani

Publikováno v: ACS Sensors

The pyochelin (PCH) siderophore produced by the pathogenic bacterium Pseudomonas aeruginosa is an important virulence factor, acting as a growth promoter during infection. While strong evidence exists for PCH production in vivo, PCH quantification in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c43235c85cc5655a7de5ba77719ee3
http://hdl.handle.net/10281/350151

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Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

Autor: Giampietro Viola, Alessandra Silvani, Elena Mattiuzzo, Roberta Bortolozzi, Alessandro Sacchetti, Andrea Luraghi

Publikováno v: Journal of Natural Products

The expression of multidrug resistance P-glycoprotein (P-gp) by cancer cells represents one of the major drawbacks to successful cancer therapy. Accordingly, the development of drugs that inhibit the activity of this transporter remains a major chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3939664e1c4d1e762a233673f993ee
http://hdl.handle.net/11311/1167112

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Phytosterol and γ-Oryzanol Conjugates: Synthesis and Evaluation of their Antioxidant, Antiproliferative, and Anticholesterol Activities

Autor: Giampietro Viola, Gabriella Roda, Alessandra Silvani, Daniela Ubiali, Giordano Lesma, Andrea Luraghi, Giulia Rainoldi, Roberta Bortolozzi, Teodora Bavaro

Publikováno v: Journal of natural products. 81(10)

Fifteen new multifunctional conjugates were designed and synthesized by chemically linking the steroidal framework of natural occurring γ-oryzanol and γ-oryzanol-derived phytosterols to a wide range of bioactive natural compounds (fatty acids, phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e020f67448ce2acfa21c698474db87
https://pubmed.ncbi.nlm.nih.gov/30360625

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Multicomponent Approach to Bioactive Peptide-Ecdysteroid Conjugates: Creating Diversity at C6 by Means of the Ugi Reaction

Autor: Elena Mattiuzzo, Giampietro Viola, Alessandra Silvani, Giordano Lesma, Roberta Bortolozzi, Andrea Luraghi, Giulia Rainoldi

An efficient multicomponent protocol has been developed to access two different kinds of peptide–ecdysteroid conjugates. The approach exploits the reactivity of the 6-keto-7-ene group of 20-OH-ecdysone, allowing the unprecedented preparation of 6-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee77693ca8b667e916e46e532835cf50
http://hdl.handle.net/10281/209482

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