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pro vyhledávání: '"Andrea Luker"'
Autor:
Geethani Bandara, Guido H. Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo. HMC-1.2 cells express constitutively a
Externí odkaz:
https://doaj.org/article/f228152ee4b24e9aa7a9dcf036833746
Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications
Publikováno v:
Pharmacologytherapeutics. 220
Mast cells are tissue-resident immune cells that play key roles in the initiation and perpetuation of allergic inflammation, usually through IgE-mediated mechanisms. Mast cells are, however, evolutionary ancient immune cells that can be traced back t
Autor:
Rebecca Martin, Yolander Valentine, Elijah Davis, Joseph Cornelius Lownik, Andrea Luker, Matthew Zellner, Joseph F. Urban, Fred D. Finkelman, Daniel Conrad
Publikováno v:
The Journal of Immunology. 200:105.6-105.6
A large amount of poly-specific IgE is generated during helminth infection. We have previously shown that innate-like B1 cells are responsible for this IgE production during infection with the nematode parasite Nippostrongylus brasiliensis. In vitro
Publikováno v:
The Journal of Immunology. 200:56.9-56.9
Immune-evasion is a difficult obstacle to overcome in cancer therapy. Through the epigenetic modifications of DNA methylation and the recruitment of immunoregulatory myeloid-derived suppressor cells (MDSCs), tumors are able to dampen the body’s ant
Autor:
Andrea Luker, Daniel Conrad
Publikováno v:
The Journal of Immunology. 200:105.14-105.14
Allergies and asthma are common ailments that are on the rise globally. Mast cells play a direct role in the signs and symptoms commonly displayed by allergic patients. The family of A Disintegrin And Metalloproteinases (ADAMs) are involved in regula
Publikováno v:
The Journal of Immunology. 198:195.18-195.18
ICOSL is an important co-stimulatory molecule involved in the development of TH2 responses through germinal center reactions. Although not well defined, the regulation of ICOSL is known to occur through its interaction with ICOS. Evidence suggests su
Autor:
Andrea Luker, Daniel Conrad
Publikováno v:
The Journal of Immunology. 198:145.10-145.10
Allergies and asthma are common ailments that are on the rise around the world. Mast cells play a direct role in the signs and symptoms characteristic in allergic patients. The family of A Disintegrin And Metalloproteinases (ADAMs) are involved in re
Publikováno v:
The Journal of Immunology. 198:152.15-152.15
The interaction between inducible costimulator (ICOS) and its ligand (ICOSL) is essential for proper T-dependent humoral immune responses, especially follicular helper T cell (TFH) development. We have demonstrated that A Disintegrin and Metalloprote