Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Andrea Loreto"'
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to n
Externí odkaz:
https://doaj.org/article/752e0ceae3fe4a6387d7e708ced0fe15
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/26dff57e67d64561bc637003537e66aa
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1
Externí odkaz:
https://doaj.org/article/11212149181f416b8c3e590d274fb1a6
Autor:
Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Giulia Perillo, Massimiliano Gasparrini, Lucia Cialabrini, Nadia Raffaelli, Carlo Angeletti, Giuseppe Orsomando, Pei-Hsuan Wu, Michael P Coleman, Andrea Loreto, Lukas Jakob Neukomm
Publikováno v:
eLife, Vol 11 (2022)
Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activati
Externí odkaz:
https://doaj.org/article/a4f6256968184f2f948689f95a99de09
Autor:
Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G. Trapanotto, Christina Antoniou, Elisa Merlini, Michael P. Coleman, Giuseppe Orsomando
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103812- (2022)
Summary: SARM1 is an NAD(P) glycohydrolase and TLR adapter with an essential, prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD(P)ases, it catalyzes multiple reactions that need to be fully investigated. Here, we
Externí odkaz:
https://doaj.org/article/3e2dd7e7c5194b30b02ec1b169d8c2d3
Autor:
Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Elisa Merlini, Peter Arthur-Farraj, Adolfo Amici, Zhenyao Luo, Lauren Hartley-Tassell, Thomas Ve, Laura M Desrochers, Qi Wang, Bostjan Kobe, Giuseppe Orsomando, Michael P Coleman
Publikováno v:
eLife, Vol 10 (2021)
Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the NAD-consuming enzyme SARM1. Here, we report a novel activator of SARM1, a metabolite of th
Externí odkaz:
https://doaj.org/article/ae90d092381c46bc9faa8cefaa0ea1fc
Autor:
Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD). Evidence suggests that ALS is a ‘dying-back’ disease, with pe
Externí odkaz:
https://doaj.org/article/b35f0addc8214d21bfcb06a8a00887df
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Traumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target. We provide evidence that targeting the axonal death pathway known as Walleria
Externí odkaz:
https://doaj.org/article/134ae4174f53449da4c29c0dbaa6c303
Autor:
Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the ide
Externí odkaz:
https://doaj.org/article/b3991ff6c7554f1da5eaf0b9425b3a69
Autor:
Ciaran Scott Hill, Andrea Loreto
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 5, Pp 980-981 (2021)
Externí odkaz:
https://doaj.org/article/e9f612b050bd4b30a64494658be81e36