Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Andrea Local"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
Rate of efflux of APTO-253 and Fe(253)3 from Raji and Raji/253R cells over first 2 hours (log fmole/10^7 cells/h)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c27f4f10ab997aa7b486eddfd07da0
https://doi.org/10.1158/1535-7163.22504885.v1
https://doi.org/10.1158/1535-7163.22504885.v1
Autor:
William G. Rice, Stephen B. Howell, Cheng-Yu Tsai, Xia Sheng, Peter Folger, Khalid D. Benbatoul, Hongying Zhang, Andrea Local
APTO-253 is a phase I clinical stage small molecule that selectively induces CDKN1A (p21), promotes G0–G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62cdb7f9dc9c577f317621302a109ba2
https://doi.org/10.1158/1535-7163.c.6537916.v1
https://doi.org/10.1158/1535-7163.c.6537916.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
The accumulation of phospho-ATM, γ-H2AFX and cleaved PARP in Raji compared to that in Raji/253R cells exposed to APTO-253 for 24 h.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3504cab9cf4a75ff11104f10ec2bc80f
https://doi.org/10.1158/1535-7163.22504894.v1
https://doi.org/10.1158/1535-7163.22504894.v1
Autor:
Jeffrey W. Tyner, Brian J. Druker, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Pierrette Lo, Stephen E. Kurtz, Andrea Local, Nasrin Rastgoo, Hongying Zhang, Stephen B. Howell, William G. Rice
Supplementary Table from Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a397862d7233705acf11f41803a0be4
https://doi.org/10.1158/1535-7163.22523650.v1
https://doi.org/10.1158/1535-7163.22523650.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
Chemical Synthesis of APTO-253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d32be7be7fa0a83442af8fa0ee38a6b
https://doi.org/10.1158/1535-7163.22504888.v1
https://doi.org/10.1158/1535-7163.22504888.v1
Autor:
Jeffrey W. Tyner, Brian J. Druker, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Pierrette Lo, Stephen E. Kurtz, Andrea Local, Nasrin Rastgoo, Hongying Zhang, Stephen B. Howell, William G. Rice
Supplementary Figure from Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce2abc023cbee9a14e0599e6113119f
https://doi.org/10.1158/1535-7163.22523653.v1
https://doi.org/10.1158/1535-7163.22523653.v1
Autor:
William G. Rice, Stephen B. Howell, Cheng-Yu Tsai, Xia Sheng, Peter Folger, Khalid D. Benbatoul, Hongying Zhang, Andrea Local
Cell growth, gene and protein expression after APTO-253 treatment. G-quadruplex binding analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00914c1a10da5b11782c50434115ce04
https://doi.org/10.1158/1535-7163.22504975.v1
https://doi.org/10.1158/1535-7163.22504975.v1
Autor:
Stephen B. Howell, William G. Rice, Larry A. Gross, Yongxuan Su, Andrea Local, Hongying Zhang, Si Sun, Cheng-Yu Tsai
APTO-253 is a small molecule with antiproliferative activity against cell lines derived from a wide range of human malignancies. We sought to determine the mechanisms of action and basis for resistance to APTO-253 so as to identify synthetic lethal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4b3c27bf0c793db2d17ac380d0ae6c
https://doi.org/10.1158/1535-7163.c.6537886.v1
https://doi.org/10.1158/1535-7163.c.6537886.v1
Autor:
William G. Rice, Stephen B. Howell, Hongying Zhang, Nasrin Rastgoo, Andrea Local, Stephen E. Kurtz, Pierrette Lo, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Brian J. Druker, Jeffrey W. Tyner
Publikováno v:
Molecular cancer therapeutics, vol 21, iss 7
Mol Cancer Ther
Mol Cancer Ther
Luxeptinib (CG-806) simultaneously targets FLT3 and select other kinase pathways operative in myeloid malignancies. We investigated the range of kinases it inhibits, its cytotoxicity landscape ex vivo with acute myeloid leukemia (AML) patient samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9e1b4488dda808b39d791155511070
https://escholarship.org/uc/item/31f6q0nd
https://escholarship.org/uc/item/31f6q0nd