Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Andrea L. Richardson"'
Autor:
Hiroji Iwata, Kerry Avery, Shelley Potter, Katherine Cowan, Andrew Spillane, Stuart McIntosh, David Dodwell, Alastair M Thompson, Rosina Ahmed, Mairead MacKenzie, Jana de Boniface, Peter Dubsky, Gustavo Werutsky, Sanjoy Chatterjee, Michael Jiang, Han-Byoel Lee, Fiorita Poulakaki, Andrea L Richardson, Karla Sepulveda, Jean L Wright, Nicholas Zdenkowski
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Neoadjuvant systemic anticancer therapy (neoSACT) is increasingly used in the treatment of early breast cancer. Response to therapy is prognostic and allows locoregional and adjuvant systemic treatments to be tailored to minimise morbidi
Externí odkaz:
https://doaj.org/article/362411acd5b845e1ad4cdee71b31a113
Autor:
Zsolt Gyüre, Ádám Póti, Eszter Németh, Bernadett Szikriszt, Rita Lózsa, Michał Krawczyk, Andrea L. Richardson, Dávid Szüts
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112887- (2023)
Summary: Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate templates by employing specialized DNA polymerases. We investigate the effect on spontaneous mutagenesis of three main TLS control mechanisms: REV
Externí odkaz:
https://doaj.org/article/96d429ad4c354fe78308b77bc4ad97b9
Autor:
Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Loss of BRCA1 or BRCA2 results in genomic instability; however most studies have focused on the role of these proteins in double-strand break repair. Here the authors coupled cell line genetics and whole genome sequencing to investigate the formation
Externí odkaz:
https://doaj.org/article/4d6fef3434494fd5bb14a0669bb5653f
Autor:
Ádám Póti, Hella Gyergyák, Eszter Németh, Orsolya Rusz, Szilárd Tóth, Csenger Kovácsházi, Dan Chen, Bernadett Szikriszt, Sándor Spisák, Shunichi Takeda, Gergely Szakács, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes
Externí odkaz:
https://doaj.org/article/8760977339c040bda5b2a0d40c280508
Autor:
Lina Ding, Ying Su, Anne Fassl, Kunihiko Hinohara, Xintao Qiu, Nicholas W. Harper, Sung Jin Huh, Noga Bloushtain-Qimron, Bojana Jovanović, Muhammad Ekram, Xiaoyuan Zi, William C. Hines, Maša Alečković, Carlos Gil del Alcazar, Ryan J. Caulfield, Dennis M. Bonal, Quang-De Nguyen, Vanessa F. Merino, Sibgat Choudhury, Gabrielle Ethington, Laura Panos, Michael Grant, William Herlihy, Alfred Au, Gedge D. Rosson, Pedram Argani, Andrea L. Richardson, Deborah Dillon, D. Craig Allred, Kirsten Babski, Elizabeth Min Hui Kim, Charles H. McDonnell, Jon Wagner, Ron Rowberry, Kristie Bobolis, Celina G. Kleer, E. Shelley Hwang, Joanne L. Blum, Simona Cristea, Piotr Sicinski, Rong Fan, Henry W. Long, Saraswati Sukumar, So Yeon Park, Judy E. Garber, Mina Bissell, Jun Yao, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes p
Externí odkaz:
https://doaj.org/article/784cf49197cf4d50824d3974f6c39d75
Autor:
Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that the
Externí odkaz:
https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f
Autor:
Artem Lomakin, Jessica Svedlund, Carina Strell, Milana Gataric, Artem Shmatko, Gleb Rukhovich, Jun Sung Park, Young Seok Ju, Stefan Dentro, Vitalii Kleshchevnikov, Vasyl Vaskivskyi, Tong Li, Omer Ali Bayraktar, Sarah Pinder, Andrea L. Richardson, Sandro Santagata, Peter J. Campbell, Hege Russnes, Moritz Gerstung, Mats Nilsson, Lucy R. Yates
Publikováno v:
Nature. 611:594-602
Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour1–3. Although these are believed to arise according to the principles of somatic evolution, the exact spatial growth patterns and underlying mechani
Autor:
Matteo D′Antonio, Donate Weghorn, Agnieszka D′Antonio-Chronowska, Florence Coulet, Katrina M. Olson, Christopher DeBoever, Frauke Drees, Angelo Arias, Hakan Alakus, Andrea L. Richardson, Richard B. Schwab, Emma K. Farley, Shamil R. Sunyaev, Kelly A Frazer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate th
Externí odkaz:
https://doaj.org/article/fed8c71471284e789fe9fe3936d957c5
Autor:
Sandra S. McAllister, Elisabeth M. Battinelli, Sabina Signoretti, Andrea L. Richardson, Victoria E. Brown, Samantha A. Hay, April Greene-Colozzi, Zafira Castaño, Beth A. Markens, Timothy Marsh, Hanna S. Kuznetsov
PDF file - 287K, Characterization of responding tumors in LBC and TNBC systemic environments suggests different mechanisms of instigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026403b268e296e299c49568b9f184ff
https://doi.org/10.1158/2159-8290.22528859.v1
https://doi.org/10.1158/2159-8290.22528859.v1
Autor:
Andrea L. Richardson, Zoltan Szallasi, Daniel P. Silver, Judy E. Garber, Paula D. Ryan, Nadine Tung, J. Dirk Iglehart, April Greene-Colozzi, Yang Li, Christian Bowman-Colin, Ruiyang Tian, Qiyuan Li, Aron C. Eklund, Ji-Young Kim, Zhigang C. Wang, Nicolai J. Birkbak
PDF file - 325K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1a4b90234da8eca618384bc14c662f
https://doi.org/10.1158/2159-8290.22528647.v1
https://doi.org/10.1158/2159-8290.22528647.v1