EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia

Autor: Andrea L. Johnstone, Jiaqi J. O'Reilly, Annika J. Patel, Zhihong Guo, Nadja S. Andrade, Marco Magistri, Lubov Nathanson, Rustam Esanov, Brooke H. Miller, Gustavo Turecki, Shaun P. Brothers, Zane Zeier, Claes Wahlestedt

Publikováno v: Neurobiology of Disease, Vol 119, Iss , Pp 149-158 (2018)

Background: With the capacity to modulate gene networks in an environmentally-sensitive manner, the role of epigenetic systems in mental disorders has come under intense investigation. Dysregulation of epigenetic effectors, including microRNAs and hi

Externí odkaz: https://doaj.org/article/06de208a240d4bfebe4f66a49f8fd752

Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma

Autor: Håkan Wallén, Andrea L. Johnstone, Saira Z Sheikh, Denis F. Noubouossie, Katherina Aguilera, Maja Månsson, Matthew R. Marunde, Charlotte Thålin, Matthew J. Meiners, Sarah A. Howard, Maud Daleskog, Martis W. Cowles, Zu-Wen Sun, Staffan Lundström, Jonathan M. Burg, Michael-Christopher Keogh, Axel Rosell, Nathan W. Hall, Marcus A. Cheek, Matthew F. Whelihan, Yohei Hisada, Nigel Mackman, Nigel S. Key, Shruti Saxena-Beem

Publikováno v: Journal of thrombosis and haemostasis : JTH

Background Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae90fd748dbb220c9c7c6d7ca84b038
https://doi.org/10.1111/jth.15003

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

Autor: Andrea L. Johnstone, Helene Damhofer, Ole N. Jensen, Michael-Christopher Keogh, Aliaksandra Radzisheuskaya, Yingqian Zhan, Richard Koche, Vasily V. Grinev, Daria Shlyueva, Vladimir Gorshkov, Ronald C. Hendrickson, Kristian Helin, Sergey Kovalchuk, Keli L. Rodriguez, Pavel V. Shliaha

Publikováno v: Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M-C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Mol Cell

Summary Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe3ef6ffe7afe53ff13473b14698e7
https://portal.findresearcher.sdu.dk/da/publications/3c30878e-5994-484c-a75b-48f2827b2915

Chromatin Immunoprecipitation (ChIP) to Study DNA–Protein Interactions

Autor: Keli L. Rodriguez, Danielle Maryanski, Andrea L. Johnstone, Michael-Christopher Keogh, Eliza C. Small, Kevin J. Harvey

Publikováno v: Methods in Molecular Biology ISBN: 9781071611852

Chromatin immunoprecipitation (ChIP) is a method used to examine the genomic localization of a target of interest (e.g., proteins, protein posttranslational modifications, or DNA elements). As ChIP provides a snapshot of in vivo DNA-protein interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f33df8feb6a0ebb1a7c3a420f2fc156
https://doi.org/10.1007/978-1-0716-1186-9_20

Biomarkers of thromboinflammation correlate to COVID-19 infection and admission status in emergency department patients

Autor: Young Erben, Matthew Auton, Taleen A. MacArthur, Bradley R. Salonen, Erica A. Loomis, Dong Chen, Ravindra Ganesh, Stephanie F. Heller, Andrew J. Kirmse, Meera Sridharan, Christopher P. Marquez, Rosemary A. Kozar, Tony Y. Chon, Julie Goswami, Kent R. Bailey, Myung S. Park, Julie Tange, Jing-fei Dong, Kaitlin A. Lundell, Grant M. Spears, Andrea L. Johnstone, Ryan T. Hurt

Publikováno v: Thrombosis Update
Thrombosis Update, Vol 5, Iss, Pp 100090-(2021)

Background: COVID-19-associated coagulopathy is incompletely understood. Objectives: To characterize thrombin generation, Von Willebrand Factor (VWF), neutrophil extracellular traps (NETs), and their role in COVID-19 risk stratification in the emerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e922a2f4b6921367d2b113a08ddb9ad7
https://doi.org/10.1016/j.tru.2021.100090