Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Andrea L. Edel"'
Publikováno v:
Journal of Functional Foods, Vol 17, Iss , Pp 948-957 (2015)
Flaxseed lignan metabolites, enterodiol (END) and enterolactone (ENL), have biological activities that may have potential therapeutic benefit through their antioxidative and oestrogenic properties. Circulating enterolignan concentrations are influenc
Externí odkaz:
https://doaj.org/article/0ff6d3cb42bc4635afc4172126ab701e
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195172 (2018)
The aim of this study was to determine the individual oxidized phosphatidylcholine (OxPC) molecules generated during renal ischemia/ reperfusion (I/R) injury.Kidney ischemia was induced in male Sprague-Dawley rats by clamping the left renal pedicle f
Externí odkaz:
https://doaj.org/article/bc89439ba5764902801e2710fd430bbe
Autor:
Andrea L. Edel, Grant N. Pierce, Chantal Y. Asselin, Davinder S. Jassal, Saroj Niraula, Antonia Zhu, Amir Ravandi, Cameron R. Eekhoudt, Ishika Mittal, J. Alejandro Austria, Pawan K. Singal, Amy Lam, James A. Thliveris, David Cheung, Andrew Mayba, Harold M. Aukema, Zahra Solati
Publikováno v:
The Journal of Nutrition. 150:2353-2363
BACKGROUND Although the combination of doxorubicin (DOX) and trastuzumab (TRZ) reduces the progression and recurrence of breast cancer, these anticancer drugs are associated with significant cardiotoxic side effects. OBJECTIVE We investigated whether
Publikováno v:
Atherosclerosis. 288:101-111
Background and aims Atherosclerosis is usually the underlying cause of heart attacks, strokes and peripheral vascular diseases – collectively known as cardiovascular diseases. Oxidation of low density lipoprotein (LDL) and its lipid content has an
Autor:
Andrea L. Edel, Elissavet Kardami, Robert R. Fandrich, Amir Ravandi, Navid Koleini, Barbara E. Nickel
Publikováno v:
Chemico-Biological Interactions. 303:35-39
Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids. In
Autor:
Viktoriya Mozolevska, David Cheung, Andrea L. Edel, Esther Kim, James A. Thliveris, Anna Schwartz, Bella Dingman, Ishika Mittal, Amir Ravandi, Piotr Czaykowski, Bilal Shaikh, Chantal Y. Asselin, Davinder S. Jassal, Vineet Goyal, Pawan K. Singal
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H446-H458
Although anticancer systemic therapy agents clearly lead to improved survival in patients with cancer, these can come at the cost of serious complications including cardiotoxicity. Two types of targeted systemic therapies currently in use for colorec
Autor:
Graham G. Maddaford, Elena Dibrov, Paul Fernyhough, Amir Ravandi, Michel Aliani, Andrea L. Edel, Grant N. Pierce, Aleksandra Stamenkovic, Kimberley A. O'Hara, Mohamad-Reza Aghanoori, David C Nelson, Lorrie A. Kirshenbaum, Thane G. Maddaford
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 320(3)
Myocardial ischemia-reperfusion (I/R) injury increases the generation of oxidized phosphatidylcholines (OxPCs), which results in cell death. However, the mechanism by which OxPCs mediate cell death and cardiac dysfunction is largely unknown. The aim
Autor:
Zahra Solati, Andrea L. Edel, Harold M. Aukema, Mandana Modirrousta, Hannah Stirton, Benjamin P. Meek, Amir Ravandi, Arun Surendran
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246592 (2021)
PLoS ONE
PLoS ONE
Background Repetitive Transcranial Magnetic Stimulation [rTMS] is increasingly being used to treat Major Depressive Disorder [MDD]. Given that not all patients respond to rTMS, it would be clinically useful to have reliable biomarkers that predict tr
Autor:
Andrea L. Edel, Mahesh Chandran, Arun Surendran, Pascal E Bogaert, Brett Hiebert, Amir Ravandi, Malek Kass, Davinder S. Jassal, Ashish H. Shah, Aneesh Kumar Asokan, Pedram Hassan-Tash, Zahra Solati, Abdul Jaleel, Michael Raabe, Shubhkarman Sandhawalia
Publikováno v:
JACC: Basic to Translational Science
This study outlines the first step toward creating the metabolite atlas of human calcified aortic valves by identifying the expression of metabolites and metabolic pathways involved at various stages of calcific aortic valve stenosis progression. Unt
Autor:
Joseph L. Witztum, Amir Ravandi, Ulrich F.W. Franke, Stefan Kath, Andrea L. Edel, Michael Torzewski, Xiaohong Yang, Jens O Schmid, Rahul Bhindi, Calvin Yeang, Sotirios Tsimikas, Laura Twardowski
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 229-240 (2017)
Summary: The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets categorize