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of 3
pro vyhledávání: '"Andrea L. Devereaux"'
Autor:
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldaña-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abuse liability. Preclinical rodent studies suggest that bifunctional ligands with both mu (MOPr) and delta (DOPr) opioid peptide receptor activity may p
Externí odkaz:
https://doaj.org/article/d66de2654cdc423f8f571b1ac7860458
Publikováno v:
ACS chemical neuroscience. 9(10)
As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chem
Autor:
John R. Traynor, Christopher W. Cunningham, Andrea L. Devereaux, Nicholas W. Griggs, Andrew Coop, Rae R. Matsumoto, Jason R. Healy, Padmavani Bezawada
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists